Abstract: Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination.

Abstract: Method and apparatus providing asynchronous neural stimulation pseudo-randomly varying at least one of a plurality of stimulation parameters. Neural stimulation may be monitored and compared with a target. Parameters may be varied to more closely match stimulation target. A range for at least one parameter may be established and the parameter varied within the range. A finite sequence of values within the range may be generated or selected. An average of the finite sequence of values may approximate the stimulation target.

Abstract: Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination.

Abstract: A medical device system includes a housing, the housing at least partially supporting a therapy module and a processor, and a respiratory monitoring element coupled to the processor. The processor is configured to activate the therapy module upon detection of a respiratory event in a respiratory signal. In some embodiments, the system may further comprise a brain monitoring element, and the processor may be configured to monitor a brain signal and change the therapeutic output based upon the brain signal.

Abstract: A medical device system that includes a brain stimulating element, cardiac monitoring element and a processor. The processor is configured to receive a brain stimulation signal from the brain stimulating element and a cardiac signal from the cardiac monitoring element. The processor is further configured to determine at least one reference point for a stimulation event time period by evaluation of the brain stimulation signal. The processor further identifies a first portion of the cardiac signal based on the at least one reference point of the stimulation event time period.

Abstract: A system for regulating or modulating cardiac therapy using brain state information. The modulation may include suppressing standard, prescribed cardiac therapy for a period of time or it may involve modulating the type of cardiac therapy delivered In another embodiment, a system is provided for determining whether a cardiac event is categorized as neurologically matched, and, if so, modulating the therapeutic output to the heart.

Abstract: A method of treating a neurological disorder in a patient. In some embodiments, the method includes obtaining a neurological event detection signal, obtaining a cardiac event detection signal, analyzing the timing relationships between the detected neurological and cardiac events to identify matched events, using the matched events to determine whether the cardiac event detection signal facilitates detection of neurological events, delivering a therapy to the patient in response to a cardiac event if the cardiac event detection signal is determined to facilitate detection of neurological events, and changing the therapy delivered based on sensed brain signals from the patient.

Abstract: A medical device system and method for monitoring cardiac signal activity in patients with nervous system disorders. In some embodiments, a brain signal and a cardiac signal are received by a processor, brain events are identified in the brain signal, and the brain events are used to identify portions of the cardiac signal. In some embodiments, Event portions of the cardiac signal are identified corresponding to brain event time periods, and Inter-event portions are identified corresponding to time periods between brain events. An Inter-event heart-rate variability (HRV) calculation is performed using Inter-event portions of the cardiac signal, and an output of the medical device system is modified based upon the calculated Inter-event HRV according to certain embodiments of the invention. An Event HRV may also be calculated according to certain embodiments, and an output modified based on comparisons of the Event HRV to the Inter-event HRV, for example.

Abstract: A system for regulating or modulating cardiac therapy using brain state information. The modulation may include suppressing standard, prescribed cardiac therapy for a period of time or it may involve modulating the type of cardiac therapy delivered In another embodiment, a system is provided for determining whether a cardiac event is categorized as neurologically matched, and, if so, modulating the therapeutic output to the heart.

Abstract: The disclosure describes a method and system for applying electrical stimulation to a pudendal nerve of a patient via an implantable electrical stimulation device to treat a pelvic disorder in men or women. Pelvic disorders may include sexual dysfunction, urinary incontinence, pudendal nerve entrapment (PNE), and urogenital pain or other forms of pelvic pain, e.g., chronic pelvic pain and prostatitis-like pain. The electrical stimulation may be applied to one or both pudendal nerves and, more particularly, to at least one of a dorsal branch and a perineal branch of one or both pudendal nerves. In some embodiments, the electrical stimulation may be applied to at least one of the dorsal and perineal branches of a pudendal nerve via a pudendal canal of the patient. In further embodiments, drug therapy may be delivered alone or in combination with electrical stimulation to one or both pudendal nerves of a patient via an implantable drug delivery device.

Abstract: The disclosure describes a method and system for applying electrical stimulation to an iliohypogastric nerve of a patient. The system includes electrical stimulators that apply electrical stimulation for alleviation of pelvic pain. The system may apply electrical stimulation for pelvic pain in men or women. The electrical stimulators may comprise various types of electrodes such as cuff electrodes, electrode leads, and microstimulators implanted at various locations proximate to a single or both iliohypogastric nerves of a patient. In particular, the electrode may be implanted proximate or adjacent to an anterior cutaneous branch of one or both iliohypogastric nerves, a lateral cutaneous branch of one or both iliohypogastric nerves, or one or both of iliohypogastric nerves above the branch point.

Abstract: The disclosure describes a method and system for delivering a drug to an ilioinguinal nerve of a patient. The system includes drug delivery devices that deliver one or more drugs for alleviation of pelvic pain. The system may deliver drug therapy for pelvic pain in men or women. Drug therapy may be delivered at various locations along a single or both ilioinguinal nerves of a patient via a fluid transfer device. In some embodiments, electrical stimulation may be applied in combination with drug therapy to one or both ilioinguinal nerves of a patient.

Abstract: The disclosure describes a method and system for delivering a drug to a genitofemoral nerve or a genital branch of a genitofemoral nerve of a patient. The system includes drug delivery devices that deliver one or more drugs for alleviation of pelvic pain. The system may deliver drug therapy for pelvic pain in men or women. Drug therapy may be delivered at various locations along a single or both genitofemoral nerves and the genital branch of a single or both genitofemoral nerves of a patient via a fluid transfer device. When implanted proximate to a genital nerve branch, the fluid transfer device may be implanted proximate to the genital nerve branch. In a male patient stimulation may be delivered proximate to the spermatic cord, which contains a portion of the genital nerve branch. In some embodiments, electrical stimulation may be applied in combination with drug therapy to a genitofemoral nerve or a genital nerve branch of the genitofemoral nerve of a patient.

Abstract: The disclosure describes a method and system for applying electrical stimulation to an ilioinguinal nerve of a patient. The system includes electrical stimulators that apply electrical stimulation for alleviation of pelvic pain. The system may apply electrical stimulation for pelvic pain in men or women. The electrical stimulators may comprise various types of electrodes such as cuff electrodes, electrode leads, and microstimulators implanted at various locations proximate to a single or both ilioinguinal nerves of a patient. In particular, the electrode may be implanted proximate or adjacent to a region of the ilioinguinal nerve above or below the inguinal canal.

Abstract: The disclosure describes a method and system for delivering a drug to an iliohypogastric nerve of a patient. The system includes drug delivery devices that deliver one or more drugs for alleviation of pelvic pain. The system may deliver drug therapy for pelvic pain in men or women. Drug therapy may made be delivered at various locations along a single or both iliohypogastric nerves of a patient via a fluid transfer device. In some embodiments, electrical stimulation may be applied in combination with drug therapy to one or both iliohypogastric nerves of a patient.

Abstract: An implantable neurostimulator device for implantation in a head of a patient includes a housing adapted to be implanted beneath a patient's scalp, and a cardiac monitoring element, a brain monitoring element, and a processor. The processor is configured to receive a cardiac signal from the cardiac monitoring element, identify cardiac events in the cardiac signal, receive a brain signal from the brain monitoring element, identify neurological events in the brain signal, and indicate a relationship between the neurological events and the cardiac events.

Abstract: A method of comparing cardiac and neurological event detection signals to indicate whether the cardiac event detection signal may facilitate detection of neurological events. The method includes obtaining a signal indicating detected neurological events, obtaining a signal indicating detected cardiac events, analyzing the timing relationships between the detected neurological and cardiac events to identify matched events, and using the matched events to indicate whether the cardiac event detection signal facilitates detection of neurological events.

Abstract: A medical device system includes a housing, a therapy module and a processor at least partially supported by the housing, and a cardiac monitoring element coupled to the processor, the cardiac monitoring element comprising a stub sensor. The processor is configured to activate the therapy module upon detection of a cardiac event in a cardiac signal. In some embodiments, the system may further comprise a brain monitoring element coupled to the processor. In some embodiments, the processor may be configured to monitor a brain signal and change the therapeutic output based upon the brain signal.

Abstract: An implantable neurostimulator device for implantation in a head of a patient includes a housing adapted to be implanted beneath a patient's scalp, a cardiac monitoring element, a therapy module, and a processor. The processor is configured to activate the therapy module to deliver a therapeutic output to treat a neurological event upon detection of a cardiac event in a cardiac signal. In some embodiments, the device may comprise a brain monitoring element. In some embodiments, the processor may be configured to receive and monitor a brain signal from the brain monitoring element and change the therapeutic output based upon the brain signal.

Abstract: The disclosure describes a method and system for applying electrical stimulation to a genitofemoral nerve or a genital branch of a genitofemoral nerve of a patient. The system includes electrical stimulators that apply electrical stimulation for alleviation of pelvic pain. The system may apply electrical stimulation for pelvic pain in men or women. The electrical stimulators may comprise various types of electrodes such as cuff electrodes, electrode leads, and microstimulators implanted at various locations proximate to a single or both genitofemoral nerves and the genital branch of a single or both genitofemoral nerves of a patient. When implanted proximate to a genital nerve branch, the electrode may be implanted proximate to the genital nerve branch. In a male patient stimulation may be delivered proximate to the spermatic cord, which contains a portion of the genital nerve branch.