Abstract: The invention relates to compositions and methods for inhibiting sphingosine kinase and for treating hyperproliferative disease.

Abstract: The invention relates to compounds, compositions and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, autoimmune disease, inflammatory disease, or allergy.

Abstract: A system for reproducing a luminance signal from a medium containing a previously recorded luminance signal with a high-frequency portion thereof compressed in dynamic range includes a circuit for recovering that luminance signal from the medium. Filtering is done to separate the low-frequency and compressed-in-dynamic-range high-frequency portions of the recovered luminance signal from each other. A corer responds to the separated compressed-in-dynamic-range high-frequency portion of the recovered luminance signal to provide a cored high-frequency portion with expanded dynamic range and reduced noise.

Abstract: A high speed optical information search system, comprising a scanning device means for scanning along the vertical lines on the optical magnetic tape, a pick-up device for sensing and accumulating data of the tape and for shift-transmitting and outputting the accumulated data in accordance with a shift clock, a memory circuit for writing and reading digital data information outputted from the pick-up device, a clock for generating clock signals corresponding to a transmission bit speed and to a speed of 5 times of a data transmission bit speed, a reading address counter for counting in accordance with a clock signal corresponding to the data transmission bit speed outputted from the clock during high and normal speed regeneration, a writing address counter for counting according to a clock signal corresponding to predetermined times of the transmission bit speed outputted from the clock during the high speed search, a writing address control circuit for controlling the output signals from the pick-up device t

Abstract: An improved video signal recording system for recording a full bandwidth video signal on a limited bandwidth medium is disclosed. The recording system includes an encoder, coupled to an input terminal, for adaptively processing a composite video signal in response to a motion representative signal, and producing two signals; a luminance signal, having attenuated high frequencies subsampled so as to be folded into a spectral hole in the low frequencies, and being bandwidth limited to the limited bandwidth of the recording medium; and a combined signal including a chrominance and a motion component. Luminance signal recording circuitry records the folded luminance signal on the medium and chrominance signal recording circuitry records the combined chrominance and motion signal on the medium. An improved video signal playback system for reproducing such a prerecorded video signal is also disclosed.