Patents by Inventor Jong-Soo Lee

Jong-Soo Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing calcobutrol
    Patent number: 11192864
    Abstract: Disclosed is a method for producing calcobutrol used as an MRI contrast agent. The method comprises the steps of: obtaining butrol represented by chemical formula 2 in the specification by reacting a gadobutrol represented by chemical formula 1 in the specification and a decomplexing agent; and obtaining a calcobutrol represented by chemical Formula 3 in the specification by reacting butrol with calcium ions.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: December 7, 2021
    Assignee: ENZYCHEM LIFESCIENCES CORPORATION
    Inventors: Jae Yong Lee, Jong Soo Lee, Byung Kyu Kang, Byuong Woo Lee, Sang Oh Lee, Dae Myoung Yun, Jae Hun Bang, Ki Young Sohn
  • Process for preparation of physiologically active polypeptide complex
    Patent number: 11168109
    Abstract: Disclosed is a method for the preparation of a complex in which a physiologically active polypeptide is covalently bonded to an immunoglobulin constant region via a non-peptidyl linker. The method is characterized by the employment of a reducing agent, by which conventional problems of low production yield and modification of the polypeptide can be overcome. The physiologically active polypeptide-non-peptidyl polymer-immunoglobulin constant region complex can be produced with high purity and yield as well as at low cost. Thus, the method is industrially useful. Moreover, by exhibiting a prolonged action profile, the physiologically active polypeptide-non-peptidyl polymer-immunoglobulin constant region complex can be effectively used for developing long-acting formulations of physiologically active polypeptides which have improved drug compliance.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: November 9, 2021
    Assignee: HANMI SCIENCE CO., LTD.
    Inventors: Myung Hyun Jang, Min Young Kim, Jong-soo Lee, Dae Jin Kim, Sung Min Bae, Se Chang Kwon
  • Deicing and snow melting compositions and methods of use
    Patent number: 11155736
    Abstract: A composition and method for safely and easily melting snow and ice is disclosed. The composition includes a pellet comprising an active ingredient; and a base comprising a water-soluble film-forming material, the pellet being attached to the base.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: October 26, 2021
    Inventor: Jong Soo Lee
  • IgG4 Fc fragment comprising modified hinge region
    Patent number: 11147857
    Abstract: A modified IgG4 Fc fragment useful as a drug carrier is disclosed. When coupled to a drug, the resulting drug-IgG4 Fc conjugate can minimize the effector functions of the IgG4 Fc and the chain exchange with in vivo IgG while maintaining in vivo activity and improving in vivo duration of the drug conjugate.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: October 19, 2021
    Assignee: HANMI PHARM. CO., LTD.
    Inventors: Sung Youb Jung, Yong Ho Huh, Sung Hee Park, Jong Soo Lee, In Young Choi
  • METHOD FOR MANUFACTURING CALTERIDOL
    Publication number: 20210284614
    Abstract: It is disclosed a method for preparing calteridol used as MRI contrast agents. It provides a method for preparing calteridol comprising: obtaining teridol represented by the following Formula 2 by reacting gadoteridol represented by the following Formula 1 with decomplexing agent; and obtaining calteridol represented by the following Formula 3 by reacting calcium ion with teridol represented by following Formula 2.
    Type: Application
    Filed: March 5, 2021
    Publication date: September 16, 2021
    Inventors: Jong Soo LEE, Dae Myoung YUN, Byuong Woo LEE
  • METHOD FOR MANUFACTURING CALCOBUTROL
    Publication number: 20210276961
    Abstract: It is disclosed a method for preparing calcobutrol, an excipient for preparing gadobutrol injections used as MRI contrast agents. the present invention provides a method for producing calcobutrol comprising: reacting lithium chloride and 4,4-dimethyl-3,5,8-trioxabicyclo[5,1,0]octane with 1,4,7,10-tetraazacyclododecane represented by the following Formula 1 to obtain a calcobutrol intermediate represented by the following Formula 2; reacting the calcobutrol intermediate represented by Formula 2 with chloroacetic acid to obtain butrol represented by the following Formula 3; and reacting butrol represented by Formula 3 with calcium ion to obtain calcobutrol represented by Formula 4 below.
    Type: Application
    Filed: March 5, 2021
    Publication date: September 9, 2021
    Inventors: Jong Soo LEE, Dae Myoung YUN, Byuong Woo LEE
  • Gadobutrol intermediate and gadobutrol production method using same
    Patent number: 11091449
    Abstract: Disclosed are: an intermediate capable of high-purity synthesis of gadobutrol which can be used as an MRI contrast agent; and a gadobutrol production method using same. The gadobutrol intermediate is represented by Chemical Formula 2 in the specification.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: August 17, 2021
    Assignee: ENZYCHEM LIFESCIENCES CORPORATION
    Inventors: Jae Young Lee, Jong Soo Lee, Byung Kyu Kang, Sang Oh Lee, Byouong Woo Lee, Dae Myoung Yun, Jae Hun Bang, Choi Kyung Seok
  • RADIO FREQUENCY (RF) INTEGRATED CIRCUIT PERFORMING SIGNAL AMPLIFICATION OPERATION TO SUPPORT CARRIER AGGREGATION AND RECEIVER INCLUDING THE SAME
    Publication number: 20210226588
    Abstract: A receiver includes an amplification block supporting carrier aggregation (CA). The amplification block includes a first amplifier circuit configured to receive a radio frequency (RF) input signal at a block node from an outside source, amplify the RF input signal, and output the amplified RF input signal as a first RF output signal. The first amplifier circuit includes a first amplifier configured to receive the RF input signal through a first input node to amplify the RF input signal, and a first feedback circuit coupled between the first input node and a first internal amplification node of the first amplifier to provide feedback to the first amplifier.
    Type: Application
    Filed: April 6, 2021
    Publication date: July 22, 2021
    Inventors: YOUNG-MIN KIM, Jong-Soo Lee, Jong-Woo Lee, Joong-Ho Lee, Ji-Young Lee, Pil-Sung Jang, Thomas Byunghak Cho, Tae-Hwan Jin
  • Radio frequency (RF) integrated circuit performing signal amplification operation to support carrier aggregation and receiver including the same
    Patent number: 11005426
    Abstract: A receiver includes an amplification block supporting carrier aggregation (CA). The amplification block includes a first amplifier circuit configured to receive a radio frequency (RF) input signal at a block node from an outside source, amplify the RF input signal, and output the amplified RF input signal as a first RF output signal. The first amplifier circuit includes a first amplifier configured to receive the RF input signal through a first input node to amplify the RF input signal, and a first feedback circuit coupled between the first input node and a first internal amplification node of the first amplifier to provide feedback to the first amplifier.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: May 11, 2021
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Young-Min Kim, Jong-Soo Lee, Jong-Woo Lee, Joong-Ho Lee, Ji-Young Lee, Pil-Sung Jang, Thomas Byunghak Cho, Tae-Hwan Jin
  • IgG4 Fc fragment comprising modified hinge region
    Patent number: 10973881
    Abstract: The present invention relates to a modified IgG4 Fc fragment useful as a drug carrier. When the modified IgG4 Fc fragment of the present invention is combined with an arbitrary drug, the resulting drug conjugate can minimize the effector functions of the IgG4 Fc and the chain exchange with in vivo IgG while maintaining in vivo activity and improving in vivo duration of the drug conjugate.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: April 13, 2021
    Assignee: HANMI PHARM. CO., LTD.
    Inventors: Sung Youb Jung, Yong Ho Huh, Sung Hee Park, Jong Soo Lee, In Young Choi
  • IGG4 FC FRAGMENT COMPRISING MODIFIED HINGE REGION
    Publication number: 20210060129
    Abstract: A modified IgG4 Fc fragment useful as a drug carrier is disclosed. When coupled to a drug, the resulting drug-IgG4 Fc conjugate can minimize the effector functions of the IgG4 Fc and the chain exchange with in vivo IgG while maintaining in vivo activity and improving in vivo duration of the drug conjugate.
    Type: Application
    Filed: November 13, 2020
    Publication date: March 4, 2021
    Applicant: HANMI PHARM. CO., LTD
    Inventors: Sung Youb JUNG, Yong Ho Huh, Sung Hee Park, Jong Soo Lee, In Young Choi
  • Long-acting insulin or insulin analogue conjugate
    Patent number: 10894089
    Abstract: The present invention relates to insulin and/or an insulin analogue conjugate, and a use thereof, wherein the insulin and/or insulin analogue have improved in vivo durability and stability by linking the same with an Fc region of immunoglobulin. The insulin and/or an insulin analogue conjugate of the present invention show an in vivo activity similar to that of insulin. In addition, the insulin and/or insulin analogue conjugate of the present invention are long-acting formulations of insulin and/or the analogue thereof, in which serum half-life is remarkably increased, and therefore, the present invention provides remarkable insulin and/or an insulin analogue conjugate, which do not induce hypoglycemia, a drawback of insulin treatment.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: January 19, 2021
    Assignee: HANMI PHARM. CO., LTD.
    Inventors: Yong Ho Heo, Jong Soo Lee, Sung Hee Park, Dae Jin Kim, Sung Youb Jung, Se Chang Kwon
  • METHOD FOR PRODUCING CALCOBUTROL
    Publication number: 20200385358
    Abstract: Disclosed is a method for producing calcobutrol used as an MRI contrast agent. The method comprises the steps of: obtaining butrol represented by chemical formula 2 in the specification by reacting a gadobutrol represented by chemical formula 1 in the specification and a decomplexing agent; and obtaining a calcobutrol represented by chemical Formula 3 in the specification by reacting butrol with calcium ions.
    Type: Application
    Filed: January 11, 2019
    Publication date: December 10, 2020
    Inventors: Jae Yong LEE, Jong Soo LEE, Byung Kyu KANG, Byuong Woo LEE, Sang Oh LEE, Dae Myoung YUN, Jae Hun BANG, Ki Young SOHN
  • COSMETIC COMPOSITION COMPRISING LIQUID-PHASE PLASMA CAPABLE OF BEING STORED FOR LONG PERIOD OF TIME AS ACTIVE INGREDIENT FOR SKIN REGENERATION OR WHITENING
    Publication number: 20200383885
    Abstract: A composition including long-term storable plasma-activated liquid (liquid plasma) as an active ingredient is disclosed. The long-term storable, atmospheric-pressure, plasma-activated liquid is prepared by dissolving a plasma generated using a low-temperature microplasma jet in a solution. The plasma-activated liquid not only exhibits a cancer cell killing effect at a level similar to gas-phase plasma according to a conventional art, but also maintains the cancer cell killing effect even when the plasma-activated liquid is stored in a freezer or in a cold chamber for 6 months, and thus is suitable for long-term storage. The plasma-activated liquid may be effectively used in the biopharmaceutical field, for example for a skin regeneration, wound-healing of dermal cells, and/or treating a cancer.
    Type: Application
    Filed: August 11, 2017
    Publication date: December 10, 2020
    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Jong Soo LEE, Sang Sik YANG
  • Device for evaluating crystallinity and method of evaluating crystallinity
    Patent number: 10801970
    Abstract: A method of evaluating crystallinity includes irradiating light from below a polycrystalline silicon substrate, allowing the irradiated light to pass through the polycrystalline silicon substrate and a circular polarizing plate disposed above the polycrystalline silicon substrate, measuring an intensity of light having passed through the circular polarizing plate at a location vertically above the circular polarizing plate, notifying that there is an error in a crystallinity of the polycrystalline silicon substrate when the measured intensity of the light is out of an error margin of a predetermined criterion intensity of light.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: October 13, 2020
    Assignee: SAMSUNG DISPLAY CO., LTD.
    Inventors: Jin Seo, Yong Jun Park, Jong Soo Lee
  • LONG ACTING PROTEIN COMPLEX HAVING AN ENHANCED EFFICIENCY
    Publication number: 20200283492
    Abstract: The present invention relates to a protein complex, in which a physiologically active polypeptide modified with a fatty acid molecule and an immunoglobulin Fc region are linked through a non-peptide polymer linker, a pharmaceutical composition comprising the same, and a method for preparing the protein complex. The protein complex extends the blood half-life of the physiologically active polypeptide through the linkage of the binding site of immunoglobulin. Fc and the intramolecular bonding of the fatty acid molecule; has an excellent in vivo activity; and has no risk of inducing an immune response.
    Type: Application
    Filed: October 1, 2018
    Publication date: September 10, 2020
    Applicant: HANMI PHARM CO., LTD.
    Inventors: Jong-Soo LEE, Eun Jung KIM, Dae Jin KIM
  • PROTEIN COMPLEX COMPRISING NON-PEPTIDYL POLYMER-COUPLED FATTY ACID DERIVATIVE COMPOUND AS LINKER AND PREPARATION METHOD THEREFOR
    Publication number: 20200276317
    Abstract: Provided are a protein conjugate in which a physiologically active polypeptide is linked to a biocompatible material via a non-peptidyl polymer-coupled fatty acid derivative compound serving as a linker, exhibiting an increased duration of physiological activity compared to natural forms and a preparation method therefor. Since an increase in serum half-life of the physiologically active polypeptide of the protein conjugate, in which the biocompatible material, the non-peptidyl polymer-coupled fatty acid derivative compound, and the physiologically active polypeptide are linked, is proved, the protein conjugate may be widely used in the field of protein drugs.
    Type: Application
    Filed: October 1, 2018
    Publication date: September 3, 2020
    Applicant: HANMl PHARM. CO., LTD.
    Inventors: Su Yeon PARK, Ji Young SONG, Eun Jung KIM, Jong Min LEE, Jong-Soo LEE, Dae Jin KIM
  • LONG-ACTING CONJUGATE OF A PHYSIOLOGICALLY ACTIVE MATERIAL AND USE THEREOF
    Publication number: 20200230250
    Abstract: The present invention relates to a conjugate including a physiologically active material, a linker, and a material capable of increasing in vivo half-life of the physiologically active material, a method for preparing the same, and a preparation thereof.
    Type: Application
    Filed: February 2, 2018
    Publication date: July 23, 2020
    Applicant: HANMI PHARM. CO., LTD.
    Inventors: Young Jin PARK, Jong-Soo LEE, In Young CHOI
  • GADOBUTROL INTERMEDIATE AND GADOBUTROL PRODUCTION METHOD USING SAME
    Publication number: 20200181098
    Abstract: Disclosed are: an intermediate capable of high-purity synthesis of gadobutrol which can be used as an MRI contrast agent; and a gadobutrol production method using same. The gadobutrol intermediate is represented by Chemical Formula 2 in the specification.
    Type: Application
    Filed: August 29, 2018
    Publication date: June 11, 2020
    Inventors: Jae Young LEE, Jong Soo LEE, Byung Kyu KANG, Sang oh LEE, Byouong Woo LEE, Dae Myoung YUN, Jae Hun BANG, CHOI Kyung Seok
  • DEICING AND SNOW MELTING COMPOSITIONS AND METHODS OF USE
    Publication number: 20200165499
    Abstract: A composition and method for safely and easily melting snow and ice is disclosed. The composition includes a pellet comprising an active ingredient; and a base comprising a water-soluble film-forming material, the pellet being attached to the base.
    Type: Application
    Filed: June 5, 2019
    Publication date: May 28, 2020
    Inventor: Jong Soo Lee