Patents by Inventor Joo Eun Chung
Joo Eun Chung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220047720Abstract: Disclosed herein is a nanoparticle composition comprising nanoparticles formed from one of: a conjugate of dimeric epigallocatechin-3-O-gallate and hyaluronic acid; a conjugate of epigallocatechin-3-O-gallate and hyaluronic acid; or a epigallocate-chin-3-O-gallate-terminated hyaluronic acid conjugate; and an active agent or a pharmaceutically acceptable salt, solvate or prodrug 0thereof suitable to treat acute myeloid leukaemia, wherein the active agent is encapsulated in the nanoparticles.Type: ApplicationFiled: December 11, 2019Publication date: February 17, 2022Applicant: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Kun Liang, Motomi Osato, Ki Hyun Bae, Nunnarpas Yongvongsoontorn, Joo Eun Chung, Qingfeng Chen, Fritz Lai, Zhisheng Her
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Patent number: 10463646Abstract: The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.Type: GrantFiled: July 18, 2018Date of Patent: November 5, 2019Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Yongvongsoontorn Nunnarpas, Jackie Y. Ying, Joo Eun Chung, Ki Hyun Bae, Min-Han Tan, Esther Lee
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Patent number: 10221253Abstract: A composite is disclosed. The composite comprises a first conjugate of a polymer and a first phenol-containing moiety, and a second conjugate of a gelatin or collagen and a second phenol-containing moiety, wherein the polymer is selected so that the first conjugate is less cell-adhesive than the second conjugate, at least one of the first and second conjugates is crosslinked to form a matrix, and the composite comprises discrete regions that are rich in one of said first and second conjugates. A method of forming such composite is also disclosed. The method comprises mixing precursors for the first and second conjugates in a solution for forming said composite, and dispersing a catalyst in the solution to catalyze crosslinking of at least one of the first and second conjugates to form the matrix. The composite may be used to grow cells.Type: GrantFiled: April 21, 2011Date of Patent: March 5, 2019Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Li Shan Wang, Joo Eun Chung
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Publication number: 20190008830Abstract: The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.Type: ApplicationFiled: July 18, 2018Publication date: January 10, 2019Inventors: Motoichi Kurisawa, Yongvongsoontorn Nunnarpas, Jackie Y. YING, Joo Eun CHUNG, Ki Hyun BAE, Min-Han TAN, Esther LEE
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Patent number: 10052307Abstract: The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.Type: GrantFiled: May 8, 2015Date of Patent: August 21, 2018Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Yongvongsoontorn Nunnarpas, Jackie Y Ying, Joo Eun Chung, Ki Hyun Bae, Min-han Tan, Esther Lee
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Publication number: 20170258926Abstract: The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.Type: ApplicationFiled: May 8, 2015Publication date: September 14, 2017Inventors: Motoichi KURISAWA, Yongvongsoontorn NUNNARPAS, Jackie Y. YING, Joo Eun CHUNG, Ki Hyun BAE, Min-han TAN, Esther LEE
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Publication number: 20170258757Abstract: There is provided a conjugate of a delivery agent containing a chemical moiety and at least one flavonoid. The flavonoid exists in a monomeric form or dimeric form before conjugation and remains in the monomeric form or dimeric form after conjugation. Preferably, the conjugate comprises two flavonoids. The delivery agent is conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. An anti-cancer agent delivery vehicle comprising an anti-cancer agent and the conjugate is also provided.Type: ApplicationFiled: May 18, 2017Publication date: September 14, 2017Inventors: Motoichi Kurisawa, Kun Liang, Susi Tan, Joo Eun Chung, Jackie Y. Ying
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Patent number: 9687464Abstract: There is provided a conjugate of a delivery agent containing a chemical moiety and at least one flavonoid. The flavonoid exists in a monomeric form or dimeric form before conjugation and remains in the monomeric form or dimeric form after conjugation. Preferably, the conjugate comprises two flavonoids. The delivery agent is conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. An anti-cancer agent delivery vehicle comprising an anti-cancer agent and the conjugate is also provided.Type: GrantFiled: March 11, 2011Date of Patent: June 27, 2017Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Kun Liang, Susi Tan, Joo Eun Chung, Jackie Y. Ying
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Patent number: 9439886Abstract: There is provided methods for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid including a method for producing a hydrogel that is capable of adhesion of cells and which comprises enzymatically cross-linked conjugates of a hydrogel forming agent and a flavonoid. There is also provided a method for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid without the addition of an exogenous peroxide or peroxidase or without the addition of an exogenous peroxide. Hydrogels produced by such methods and methods of using the hydrogels are also described herein.Type: GrantFiled: April 27, 2015Date of Patent: September 13, 2016Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Fan Lee, Joo Eun Chung, Pui Yik Peggy Chan
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Publication number: 20160106706Abstract: There is provided a delivery vehicle comprising an anti-cancer agent together with a conjugate of a delivery agent containing a free aldehyde and a flavonoid, having the delivery agent conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. The resulting delivery vehicles may be used to deliver an anti-cancer agent to a cell.Type: ApplicationFiled: December 21, 2015Publication date: April 21, 2016Applicant: Agency for Science, Technology and ResearchInventors: Jackie Y. Ying, Joo Eun Chung, Motoichi Kurisawa
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Patent number: 9248200Abstract: There is provided a delivery vehicle comprising an anti-cancer agent together with a conjugate of a delivery agent containing a free aldehyde and a flavonoid, having the delivery agent conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. The resulting delivery vehicles may be used to deliver an anti-cancer agent to a cell.Type: GrantFiled: October 23, 2008Date of Patent: February 2, 2016Assignee: Agency for Science, Technology and ResearchInventors: Jackie Y. Ying, Joo Eun Chung, Motoichi Kurisawa
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Patent number: 9226899Abstract: There is presently provided a suspension of immiscible particles in a solution, wherein the particles comprise an agglomeration of a bioactive agent, for example an anti-cancer agent; and a plurality of conjugates of a hyaluronic acid and a flavonoid, for example a catechin-based flavonoid, wherein the particles are on average from about 15 nm to about 300 nm in diameter and wherein the bioactive agent is releasably retained in the particles by the flavonoid. The suspension is useful for delivery of the bioactive agent to cells, including cancer cells. There are also provided a therapeutic formulation comprising the suspension, as well as methods for using the suspension and therapeutic formulation, including for delivery of a bioactive agent to a cell and for treating a disease, including cancer.Type: GrantFiled: May 30, 2014Date of Patent: January 5, 2016Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Shengyong Ng, Joo Eun Chung
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Publication number: 20150313869Abstract: There is provided methods for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid including a method for producing a hydrogel that is capable of adhesion of cells and which comprises enzymatically cross-linked conjugates of a hydrogel forming agent and a flavonoid. There is also provided a method for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid without the addition of an exogenous peroxide or peroxidase or without the addition of an exogenous peroxide. Hydrogels produced by such methods and methods of using the hydrogels are also described herein.Type: ApplicationFiled: April 27, 2015Publication date: November 5, 2015Applicant: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Fan Lee, Joo Eun Chung, Pui Yik Peggy Chan
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Patent number: 9034364Abstract: There are provided methods for producing a hydrogel that is capable of adhesion of cells and which comprises enzymatically cross-linked conjugates of a hydrogel forming agent and a flavonoid, formed from a reaction using peroxide and peroxidase. Hydrogels produced by such methods and methods of using the hydrogels are also provided.Type: GrantFiled: August 19, 2013Date of Patent: May 19, 2015Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Fan Lee, Joo Eun Chung, Pui Yik Peggy Chan
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Publication number: 20140271902Abstract: There is presently provided a suspension of immiscible particles in a solution, wherein the particles comprise an agglomeration of a bioactive agent; and a plurality of conjugates of a hyaluronic acid and a flavonoid wherein the particles are on average from about 15 nm to about 300 nm in diameter and wherein the bioactive agent is releasably retained in the particles by the flavonoid. There is also provided a therapeutic formulation comprising such a suspension and methods for using the suspension and therapeutic formulation, including for delivery of a bioactive agent to a cell and for treating a disease, including cancer.Type: ApplicationFiled: May 30, 2014Publication date: September 18, 2014Inventors: Motoichi KURISAWA, Shengyong NG, Joo Eun CHUNG
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Patent number: 8753687Abstract: There is presently provided a suspension of immiscible particles in a solution, wherein the particles comprise an agglomeration of a bioactive agent, for example an anti-cancer agent; and a plurality of conjugates of a hyaluronic acid and a flavonoid, for example a catechin-based flavonoid, wherein the particles are on average from about 15 nm to about 300 nm in diameter and wherein the bioactive agent is releasably retained in the particles by the flavonoid. The suspension is useful for the delivery of the bioactive agent to cells, including cancer cells. There are also provided a therapeutic formulation comprising the suspension, as well as methods for using the suspension and therapeutic formulation, including for delivery of a bioactive agent to a cell and for treating a disease, including cancer.Type: GrantFiled: August 11, 2010Date of Patent: June 17, 2014Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Shengyong Ng, Joo Eun Chung
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Patent number: 8691206Abstract: In a process of forming a hydrogel from a mixture comprising hydrogen peroxide (H2O2), horseradish peroxidase (HRP), and a polymer comprising a crosslinkable phenol group, the gelation rate in the solution and the crosslinking density in the hydrogel can be independently adjusted or controlled by selection of the molarity of H2O2 and concentration of HRP in the solution when the molarity of H2O2 is limited to be within a range and the concentration of HRP is limited to be above a threshold. A method for determining the range and threshold is disclosed. The hydrogel may be used to grow cells, in which case, the molarity of H2O2 may be selected to affect the differentiation or growth rate of the cells in the hydrogel. Also, the hydrogel system may be used for sustained delivery of a therapeutic protein, for example in the treatment of liver cancer, fibrosis or hepatitis.Type: GrantFiled: December 23, 2011Date of Patent: April 8, 2014Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Li Shan Wang, Joo Eun Chung, Fan Lee, Keming Xu, Hirohisa Yano
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Publication number: 20130338101Abstract: There are provided methods for producing a hydrogel that is capable of adhesion of cells and which comprises enzymatically cross-linked conjugates of a hydrogel forming agent and a flavonoid, formed from a reaction using peroxide and peroxidase. Hydrogels produced by such methods and methods of using the hydrogels are also provided.Type: ApplicationFiled: August 19, 2013Publication date: December 19, 2013Inventors: Motoichi Kurisawa, Fan Lee, Joo Eun Chung, Pui Yik Peggy Chan
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Patent number: 8541016Abstract: There are provided methods for producing a hydrogel that is capable of adhesion of cells and which comprises enzymatically cross-linked conjugates of a hydrogel forming agent and a flavonoid, formed from a reaction using peroxide and peroxidase. Hydrogels produced by such methods and methods of using the hydrogels are also provided.Type: GrantFiled: May 17, 2010Date of Patent: September 24, 2013Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Fan Lee, Joo Eun Chung, Pui Yik Chan
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Patent number: 8410165Abstract: There is provided a method of conjugating a polymer containing a free aldehyde group with a flavonoid in the presence of an acid catalyst, such that the polymer is conjugated to the C6 or C8 position of the flavonoid A ring. The resulting conjugates may be used to form delivery vehicles to deliver high doses of flavonoids, and may also be used as delivery vehicles to deliver an additional bioactive agent.Type: GrantFiled: September 23, 2011Date of Patent: April 2, 2013Assignee: Agency for Science, Technology and ResearchInventors: Joo Eun Chung, Motoichi Kurisawa, Yi Yan Yang, Lang Zhuo