Abstract: A method is for sterilization of flexible bags containing human plasma protein solution with electron beam. The method includes emitting at least one electron beam with energy between 400 and 500 keV. After approximately 10 nsec to 1.5 sec, a second electron beam pulse is emitted with an energy of at least 4 MeV.

Abstract: Method for the aseptic filling of a bag with a pharmaceutical product or liquid which comprises the following steps: a) a first step in which the cap is inserted in the inlet of the bag; b) a second step in which said cap is raised and the pharmaceutical product or liquid concerned is introduced; c) a third step in which the cap is re-inserted in the inlet of the bag; and d) a fourth step in which the cap and the inlet of the bag are welded.

Abstract: An device is for electron-beam irradiation sterilization of flexible bags that may contain human plasma protein solutions for therapeutic use. The device has two electron accelerators, a first accelerator emitting an electron beam with energies between 400 and 500 keV and a second accelerator emitting an electron beam with an energy of at least 4 MeV. A sterilization method by electron-beam irradiation provides sterilization of such flexible bags. An in-line filling process for flexible bags can use the sterilization device and method.

Abstract: A unit for automatically collecting blood and/or plasma, includes a number of stations for automatically collecting blood and/or plasma and at least one venepuncture robot. The robot has a blood vessel detector. The robot is fitted on a linear guide and is movable on the linear guide. The stations are laid out along the linear guide such that the robot can move along the linear guide to access the stations.

Abstract: Method for the aseptic filling of a bag with a pharmaceutical product or liquid which comprises the following steps: a) a first step in which the cap is inserted in the inlet of the bag; b) a second step in which said cap is raised and the pharmaceutical product or liquid concerned is introduced; c) a third step in which the cap is re-inserted in the inlet of the bag; and d) a fourth step in which the cap and the inlet of the bag are welded.

Abstract: A system for dispensing a liquid in a closed chamber includes at least one rapid transfer port in at least one wall of the closed chamber. In addition, a liquid is dispensed in a closed chamber that includes at least one rapid transfer port in at least one wall of the closed chamber.

Abstract: A system for the sterile filling of containers for pharmaceutical products, which includes a device for sterilizing containers and a machine for filling sterilized containers, wherein the device for sterilizing containers includes at least one autoclave, and wherein the system includes an automated container-accumulation device and means for automatically transporting the containers sterilized in the autoclave from said autoclave to the container-filling machine via said container-accumulation device.

Abstract: A sterilization method includes irradiating flexible bags, in particular, bags of the type that can contain solutions of human plasma proteins for therapeutic use. The sterilization method includes electron beam irradiation. An in-line method for filling flexible bags of the type that can contain solutions of human plasma proteins for therapeutic use can use the sterilization method.

Abstract: A container for sterilizing flexible bags can be for pharmaceutical use. The container includes an upper flat structure including at least one element supporting the flexible bags and designed to accommodate a plug port of the flexible bag. The support element includes at least one fastening element, which is suitable for retaining the flexible bags once they are inserted into the support element. The container also includes a lower receptacle designed to contain the upper flat structure and to couple to the upper flat structure in a detachable manner. The container further includes a cap for hermetically sealing the lower receptacle.

Abstract: A sterilization method includes irradiating flexible bags, in particular, bags of the type that can contain solutions of human plasma proteins for therapeutic use. The sterilization method includes electron beam irradiation. An in-line method for filling flexible bags of the type that can contain solutions of human plasma proteins for therapeutic use can use the sterilization method.

Abstract: A device is for sterilization by electron beam irradiation of flexible bags, in particular flexible bags of the type that can contain solutions of human plasma proteins for therapeutic use. A sterilization method includes irradiating flexible bags by electron beam irradiation. An in-line method for filling flexible can use the sterilization device and method.

Abstract: An automatic device for emptying bags of frozen blood product includes a product removal device, a product reception hopper, a transporter for transporting the bag from a reception area to the product removal device, and at least one cutter located in the path of the bag between the reception area and the product removal device. The at least one cutter is housed in a support configured to oscillate for absorbing energy of impacts of the bag against the cutter and to return the cutter to its initial position.

Abstract: An device is for electron-beam irradiation sterilization of flexible bags that may contain human plasma protein solutions for therapeutic use. The device has two electron accelerators, a first accelerator emitting an electron beam with energies between 400 and 500 keV and a second accelerator emitting an electron beam with an energy of at least 4 MeV. A sterilization method by electron-beam irradiation provides sterilization of such flexible bags. An in-line filling process for flexible bags can use the sterilization device and method.

Abstract: A container for sterilizing flexible bags can be for pharmaceutical use. The container includes an upper flat structure including at least one element supporting the flexible bags and designed to accommodate a plug port of the flexible bag. The support element includes at least one fastening element, which is suitable for retaining the flexible bags once they are inserted into the support element. The container also includes a lower receptacle designed to contain the upper flat structure and to couple to the upper flat structure in a detachable manner. The container further includes a cap for hermetically sealing the lower receptacle.

Abstract: Method for the aseptic filling of a bag with a pharmaceutical product or liquid which comprises the following steps: a) a first step in which the cap is inserted in the inlet of the bag; b) a second step in which said cap is raised and the pharmaceutical product or liquid concerned is introduced; c) a third step in which the cap is re-inserted in the inlet of the bag; and d) a fourth step in which the cap and the inlet of the bag are welded.

Abstract: Method for the aseptic filling of a bag with a pharmaceutical product or liquid which comprises the following steps: a) a first step in which the cap is inserted in the inlet of the bag; b) a second step in which said cap is raised and the pharmaceutical product or liquid concerned is introduced; c) a third step in which the cap is re-inserted in the inlet of the bag; and d) a fourth step in which the cap and the inlet of the bag are welded.

Abstract: A method and device detect defects in the closure of encapsulated vials. The method includes scanning a profile of the capsule and of the vial using a profilometer, thus obtaining a point cloud. From the point cloud obtained, calculating at least one of the following parameters: diameter or radius of the closure circumference of the capsule; angle of intersection between the lower skirt and the side of the capsule; length of the lower skirt; and/or a distance from the end of the lower skirt to the neck of the vial. The method determines whether any of the parameters calculated in the previous step exceeds a predetermined value. The device detecting defects in the closure of encapsulated vials includes a profilometer configured to scan a profile of the capsule and of the vial and a control device configured to execute the method.

Abstract: Method for the aseptic filling of a bag with a pharmaceutical product or liquid which comprises the following steps: a) a first step in which the cap is inserted in the inlet of the bag; b) a second step in which said cap is raised and the pharmaceutical product or liquid concerned is introduced; c) a third step in which the cap is re-inserted in the inlet of the bag; and d) a fourth step in which the cap and the inlet of the bag are welded.

Abstract: A method and device detect defects in the closure of encapsulated vials. The method includes scanning a profile of the capsule and of the vial using a profilometer, thus obtaining a point cloud. From the point cloud obtained, calculating at least one of the following parameters: diameter or radius of the closure circumference of the capsule; angle of intersection between the lower skirt and the side of the capsule; length of the lower skirt; and/or a distance from the end of the lower skirt to the neck of the vial. The method determines whether any of the parameters calculated in the previous step exceeds a predetermined value. The device detecting defects in the closure of encapsulated vials includes a profilometer configured to scan a profile of the capsule and of the vial and a control device configured to execute the method.

Abstract: A device is for sterilization by electron beam irradiation of flexible bags, in particular flexible bags of the type that can contain solutions of human plasma proteins for therapeutic use. A sterilization method includes irradiating flexible bags by electron beam irradiation. An in-line method for filling flexible can use the sterilization device and method.