Patents by Inventor Jorg Hoheisel
Jorg Hoheisel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240036048Abstract: The present invention pertains to the field of cancer diagnosis. Specifically, it relates to a method for diagnosing pancreas cancer in a subject comprising the steps of determining in a sample of a subject suspected to suffer from pancreas cancer the amount of at least one biomarker selected from the biomarkers shown in Table 1 and comparing the said amount of the at least one biomarker with a reference, whereby pancreas cancer is to be diagnosed. The present invention also contemplates a method for identifying whether a subject is in need of a pancreas cancer therapy comprising the steps of the aforementioned methods and the further step of identifying a subject in need of a pancreas cancer therapy if said subject is to be diagnosed to suffer from pancreas cancer. Contemplated are, furthermore, diagnostic devices and kits for carrying out said methods.Type: ApplicationFiled: June 26, 2023Publication date: February 1, 2024Applicants: Deutsches Krebsforschungszentrum, Queen Mary University of LondonInventors: Christoph SCHRÖDER, Jörg HOHEISEL, Tatjana CRNOGORAC-JURCEVIC
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Patent number: 11726090Abstract: The present invention pertains to the field of cancer diagnosis. Specifically, it relates to a method for diagnosing pancreas cancer in a subject comprising the steps of determining in a sample of a subject suspected to suffer from pancreas cancer the amount of at least one biomarker selected from the biomarkers shown in Table 1 and comparing the said amount of the at least one biomarker with a reference, whereby pancreas cancer is to be diagnosed. The present invention also contemplates a method for identifying whether a subject is in need of a pancreas cancer therapy comprising the steps of the aforementioned methods and the further step of identifying a subject in need of a pancreas cancer therapy if said subject is to be diagnosed to suffer from pancreas cancer. Contemplated are, furthermore, diagnostic devices and kits for carrying out said methods.Type: GrantFiled: December 21, 2016Date of Patent: August 15, 2023Assignees: DEUTSCHES KREBSFORSCHUNGSZENTRUM, QUEEN MARY UNIVERSITY OF LONDONInventors: Christoph Schröder, Jörg Hoheisel, Tatjana Crnogorac-Jurcevic
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Publication number: 20210123914Abstract: The present invention pertains to the field of cancer prediction. Specifically, it relates to a method for predicting the risk of recurrence of bladder cancer in a subject after treatment of bladder cancer comprising the steps of determining the amount of at least one biomarker selected from the biomarkers shown in Table, and comparing the amount of said at least one biomarker with a reference amount for said at least one biomarker, whereby the risk of recurrence of bladder cancer is to be predicted. The present invention also contemplates a method for identifying a subject being in need of a further bladder cancer therapy. Encompassed are, furthermore, diagnostic devices and kits for carrying out said methods.Type: ApplicationFiled: September 25, 2020Publication date: April 29, 2021Applicants: Deutsches Krebsforschungszentrum, Institut CurieInventors: Christoph SCHRÖDER, Harish SRINIVASAN, Jörg HOHEISEL, François RADVANYI
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Patent number: 10809261Abstract: The present invention pertains to the field of cancer prediction. Specifically, it relates to a method for predicting the risk of recurrence of bladder cancer in a subject after treatment of bladder cancer comprising the steps of determining the amount of at least one biomarker selected from the biomarkers shown in Table, and comparing the amount of said at least one biomarker with a reference amount for said at least one biomarker, whereby the risk of recurrence of bladder cancer is to be predicted. The present invention also contemplates a method for identifying a subject being in need of a further bladder cancer therapy. Encompassed are, furthermore, diagnostic devices and kits for carrying out said methods.Type: GrantFiled: May 8, 2017Date of Patent: October 20, 2020Assignees: DEUTSCHES KREBSFORSCHUNGSZENTRUM, INSTITUT CURIEInventors: Christoph Schröder, Harish Srinivasan, Jörg Hoheisel, François Radvanyi
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Patent number: 10420757Abstract: The current disclosure relates to methods for treating pancreatic cancer or chronic pancreatitis in a subject comprising administering an antagonist of a dopamine receptor to the subject wherein the dopamine receptor is, in some specific cases dopamine receptor D2 (DRD2). The antagonist in some specific cases is an RNAi construct, an antibody, or a small molecule and in more specific cases pimozide or L-741,626. The disclosure also relates to diagnostic methods comprising the detection of the expression of DRD2 in pancreatic tissue and kits for doing the same.Type: GrantFiled: April 17, 2015Date of Patent: September 24, 2019Assignees: Deutsches Krebsforschungszentrum Stiftung des Öffentlichenrechts, The Royal Institution for the Advancement of Learning/McGill UniversityInventors: Pouria Jandaghi, Jörg Hoheisel, Yasser Riazalhosseini
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Publication number: 20170336414Abstract: The present invention pertains to the field of cancer prediction. Specifically, it relates to a method for predicting the risk of recurrence of bladder cancer in a subject after treatment of bladder cancer comprising the steps of determining the amount of at least one biomarker selected from the biomarkers shown in Table, and comparing the amount of said at least one biomarker with a reference amount for said at least one biomarker, whereby the risk of recurrence of bladder cancer is to be predicted. The present invention also contemplates a method for identifying a subject being in need of a further bladder cancer therapy. Encompassed are, furthermore, diagnostic devices and kits for carrying out said methods.Type: ApplicationFiled: May 8, 2017Publication date: November 23, 2017Applicants: Deutsches Krebsforschungszentrum, Institut CurieInventors: Christoph SCHRODER, Harish SRINIVASAN, Jõrg HOHEISEL, François RADVANYI
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Publication number: 20170168062Abstract: The present invention pertains to the field of cancer diagnosis. Specifically, it relates to a method for diagnosing pancreas cancer in a subject comprising the steps of determining in a sample of a subject suspected to suffer from pancreas cancer the amount of at least one biomarker selected from the biomarkers shown in Table 1 and comparing the said amount of the at least one biomarker with a reference, whereby pancreas cancer is to be diagnosed. The present invention also contemplates a method for identifying whether a subject is in need of a pancreas cancer therapy comprising the steps of the aforementioned methods and the further step of identifying a subject in need of a pancreas cancer therapy if said subject is to be diagnosed to suffer from pancreas cancer. Contemplated are, furthermore, diagnostic devices and kits for carrying out said methods.Type: ApplicationFiled: December 21, 2016Publication date: June 15, 2017Applicants: Deutsches Krebsforschungszentrum, Queen Mary University of LondonInventors: Christoph SCHRÖDER, Jörg HOHEISEL, Tatjana CRNOGORAC-JURCEVIC
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Patent number: 9678075Abstract: The present invention pertains to the field of cancer prediction. Specifically, it relates to a method for predicting the risk of recurrence of bladder cancer in a subject after treatment of bladder cancer comprising the steps of determining the amount of at least one biomarker selected from the biomarkers shown in Table, and comparing the amount of said at least one biomarker with a reference amount for said at least one biomarker, whereby the risk of recurrence of bladder cancer is to be predicted. The present invention also contemplates a method for identifying a subject being in need of a further bladder cancer therapy. Encompassed are, furthermore, diagnostic devices and kits for carrying out said methods.Type: GrantFiled: June 8, 2012Date of Patent: June 13, 2017Assignees: Deutsches Krebsforschungszentrum, Institut CurieInventors: Christoph Schröder, Harish Srinivasan, Jörg Hoheisel, François Radvanyi
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Publication number: 20170035746Abstract: The present invention provides novel cancer therapeutics for treating pancreatic cancer, and novel diagnostic methods for detecting chronic pancreatitis and pancreatic cancer. The invention pertains to antagonists of dopamine receptors that inhibit the growth of pancreatic cancer cells. The invention in particular offers new therapy options based on the inhibition of the activity or expression of dopamine receptor D2 (DRD2). Diagnostic methods of the invention comprise the detection of the expression of DRD2 in pancreatic tissue. Diagnostic kits are also comprised.Type: ApplicationFiled: April 17, 2015Publication date: February 9, 2017Inventors: Jandaghi POURIA, Jörg HOHEISEL, Yasser RIAZALHOSSEINI
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Patent number: 9551035Abstract: The present invention pertains to the field of cancer diagnosis. Specifically, it relates to a method for diagnosing pancreas cancer in a subject comprising the steps of determining in a sample of a subject suspected to suffer from pancreas cancer the amount of at least one biomarker selected from the biomarkers shown in Table 1 and comparing the said amount of the at least one biomarker with a reference, whereby pancreas cancer is to be diagnosed. The present invention also contemplates a method for identifying whether a subject is in need of a pancreas cancer therapy comprising the steps of the aforementioned methods and the further step of identifying a subject in need of a pancreas cancer therapy if said subject is to be diagnosed to suffer from pancreas cancer. Contemplated are, furthermore, diagnostic devices and kits for carrying out said methods.Type: GrantFiled: February 15, 2011Date of Patent: January 24, 2017Assignees: DEUTSCHES KREBSFORSCHUNGSZENTRUM, QUEEN MARY UNIVERSITY OF LONDONInventors: Christoph Schröder, Jörg Hoheisel, Tatjana Crnogorac-Jurcevic
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Publication number: 20130274440Abstract: The present invention concerns a new dimedon derivative and a method for the purification of PNA and peptide oligomers.Type: ApplicationFiled: April 8, 2013Publication date: October 17, 2013Inventors: Anette JACOB, Jörg HOHEISEL, Marc DAUBER, Manfred WIESSLER, Peter LORENZ, Heinz FLEISCHHACKER, Hans-Christian KLIEM
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Publication number: 20130045884Abstract: The present invention pertains to the field of cancer diagnosis. Specifically, it relates to a method for diagnosing pancreas cancer in a subject comprising the steps of determining in a sample of a subject suspected to suffer from pancreas cancer the amount of at least one biomarker selected from the biomarkers shown in Table 1 and comparing the said amount of the at least one biomarker with a reference, whereby pancreas cancer is to be diagnosed. The present invention also contemplates a method for identifying whether a subject is in need of a pancreas cancer therapy comprising the steps of the aforementioned methods and the further step of identifying a subject in need of a pancreas cancer therapy if said subject is to be diagnosed to suffer from pancreas cancer. Contemplated are, furthermore, diagnostic devices and kits for carrying out said methods.Type: ApplicationFiled: February 15, 2011Publication date: February 21, 2013Applicant: Deutsches KrebsforschungszentrumInventors: Christoph Schröder, Jörg Hoheisel, Tatjana Crnogorac-Jurcevic
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Patent number: 8008434Abstract: The invention relates to a process for the preparation of at least one solid phase bound peptide. PNA or a chimera.Type: GrantFiled: May 25, 2005Date of Patent: August 30, 2011Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen RechtsInventors: Ole Brandt, Anette Jacob, Jörg Hoheisel
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Publication number: 20110082047Abstract: The present invention provides a genome-wide methodology for identifying single nucleotide polymorphisms and mutations related to disease conditions, such as cancer. Specifically, the invention provides methods for detecting genome-wide mutations by successively amplifying sequence differences between two sample populations.Type: ApplicationFiled: July 30, 2007Publication date: April 7, 2011Inventors: Jörg Hoheisel, Philipp Angenendt
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Publication number: 20090162841Abstract: Described is an improved method of selecting a member of a specific binding pair (sbp) having a desired specify, preferably an antibody, from a library expressing said member of a sbp, preferably a phage-display antibody library.Type: ApplicationFiled: August 3, 2005Publication date: June 25, 2009Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTING DES OFFENTLICHEN RECHTSInventor: Jorg Hoheisel
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Publication number: 20090104182Abstract: The present invention relates to compounds suitable for the treatment of conditions which may be improved, at least in part, by increasing TNF ? production. The invention further relates to assays for the identification of an individual at increased risk for or suffering front such conditions and to methods of screening compounds for their ability to enhance TNF ? biosynthesis.Type: ApplicationFiled: September 26, 2008Publication date: April 23, 2009Inventors: Franz-Werner KLUXEN, Bernd HENTSCH, Thomas EHRING, Marian BRANDLE, Jorg HOHEISEL, Marcus FROHME, Dimitri ZUBAKOV
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Publication number: 20090012265Abstract: This invention relates to a method of producing a purified polymer selected from the group consisting of PNAs, (poly)peptides, PNA chimera, peptide-DNA chimera, and derivatives thereof, wherein the polymer carries at least one lipophilic group and wherein the method comprises the following steps: (a) transferring a solution comprising the polymer carrying a lipophilic group to a lipophilic surface under conditions that allow binding of said lipophilic group to said lipophilic surface; (b) washing said surface under conditions that allow said binding to be maintained, wherein polymers not carrying said lipophilic group are removed; (c) washing said surface under conditions that break said binding; (d) collecting the washing solution from step (c); and (e) obtaining said purified polymer from said washing solution. Preferably, the lipophilic group is a protection group, or a label such as a fluorescent dye, or a linker, for example a linker suitable for immobilization on a support.Type: ApplicationFiled: May 30, 2005Publication date: January 8, 2009Inventors: Anette Jacob, Jorg Hoheisel, Ole Brandt
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Publication number: 20080045694Abstract: The invention relates to a process for the preparation of at least one solid phase bound peptide. PNA or a chimera.Type: ApplicationFiled: May 25, 2005Publication date: February 21, 2008Inventors: Ole Brandt, Anette Jacob, Jorg Hoheisel
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Publication number: 20060252157Abstract: Larynx carcinoma associated protein-1 (LarCAP-1) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing LatCAP-1 polypeptides and polynucleotides in diagnostic assays.Type: ApplicationFiled: February 12, 2001Publication date: November 9, 2006Inventors: Klaus Ducker, Bernd Hentsch, Marcus Frohme, Jorg Hoheisel
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Publication number: 20060216750Abstract: New Lipid Binding Protein 1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing New Lipid Binding Protein 1 polypeptides and polynucleotides in diagnostic assays.Type: ApplicationFiled: December 22, 2005Publication date: September 28, 2006Inventors: Matthias Grell, Klaus Ducker, Jorg Hoheisel, Marcus Frohme