Abstract: A machine-implemented method, computing device, and at least one non-transitory computer-readable medium are provided. A dynamical network model is parameterized by state transition matrices based on monitored interictal brain data. A node influence-to network score for each respective node is calculated indicating how influential the respective node is. An influenced-by score is calculated for the each respective node indicating an amount by which the respective node is influenced by the nodes. A score is calculated for the each respective node based on a sink index, a source influence index, and a sink connectivity index. Nodes that are in the epileptogenic zone are determined based on the calculated score for each of the nodes. An indication of the nodes in the epileptogenic zone is provided.

Abstract: A method of identifying an epileptogenic zone of a subjects brain includes: receiving a plurality N of physiological brain signals that extend over a duration, each of the plurality N of physiological brain signals acquired from the subjects brain; calculating within a time window a state transition matrix based on at least a portion of each of the plurality N of physiological brain signals, wherein the state transition matrix is a linear time invariant model of a network of N nodes corresponding to the plurality N of physiological brain signals; calculating a minimum norm of a perturbation on the state transition matrix that causes the network to transition from a stable state to an unstable state; and assigning a fragility metric to each of the plurality N of physiological brain signals based on the minimum norm of the perturbation for that physiological brain signal.

Abstract: This disclosure relates to using stereo-thermo-lesioning (STL) to create lesions at one or more locations in the patient's nervous system at the patient's bedside without general anesthesia. A method that uses STL to treat a patient's neurological condition includes: using a plurality of stereotactically-implanted thermo-coupled multi-contact electrodes to record conduction data within a predetermined theoretical zone of activity within the patient's neurological tissue; detecting abnormal neurological activity of a neurological condition within the conduction data and localize a portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity; creating a lesion at the portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity using at least one contact of the plurality of thermo-coupled multi-contact electrodes.

Abstract: This disclosure relates to forming a lesion in a patient's neurological tissue without requiring general anesthesia. The lesion can be either temporary or permanent. In either case, the lesion can be created by a steerable probe that includes a steerable guide, a laser device, and at least one electrode. The steerable guide steers the probe to a target location in the subject's neurological tissue. When the probe reaches the target location, the laser can create the lesion. The at least one electrode can detect a progressive vanishing of neural activity from the portion of the neurological tissue due to the lesion.

Abstract: The disclosure herein describes receiving wireless signal strength data and detecting movement of a computing device relative to wireless access points based thereon. The computing device receives a signal strength data stream based on a wireless signal from a wireless access point. A signal strength range is determined based on the signal strength data stream during a learning time period while the computing device is within a defined area. The signal strength range indicates that the computing device is within the defined area associated with the wireless access point. During a detection time period, signal strength values outside of the signal strength range are detected and, based on the detected values, a notification is provided that indicates the computing device has moved outside the defined area. The described movement detection method provides rapid detection of movements of a computing device using already-obtained data that does not rely on interaction with other devices.

Abstract: The disclosure herein describes receiving wireless signal strength data and detecting movement of a computing device relative to wireless access points based thereon. The computing device receives a signal strength data stream based on a wireless signal from a wireless access point. A signal strength range is determined based on the signal strength data stream during a learning time period while the computing device is within a defined area. The signal strength range indicates that the computing device is within the defined area associated with the wireless access point. During a detection time period, signal strength values outside of the signal strength range are detected and, based on the detected values, a notification is provided that indicates the computing device has moved outside the defined area. The described movement detection method provides rapid detection of movements of a computing device using already-obtained data that does not rely on interaction with other devices.

Abstract: The present disclosure relates generally to precise stereotactic implantation of an instrument (e.g., a recording electrode, a stimulating electrode, a biopsy instrument, a catheter, a delivery device, and the like) into a target area in a patient's brain. As such, one aspect of the present disclosure can relate to a stereotactic device that can be used to accomplish the precise implantation of the instrument. The stereotactic device can include a body to secure the stereotactic device to the patient's head. In some instances, the body can have a u-shape. The stereotactic device can also include a guide attached between sides of the body to move an instrument holder into place above a target area. The guide can be locked in position to lock the instrument holder in the place to facilitate injection of the instrument into the target area.

Abstract: A method of identifying an epileptogenic zone of a subjects brain includes: receiving a plurality N of physiological brain signals that extend over a duration, each of the plurality N of physiological brain signals acquired from the subjects brain; calculating within a time window a state transition matrix based on at least a portion of each of the plurality N of physiological brain signals, wherein the state transition matrix is a linear time invariant model of a network of N nodes corresponding to the plurality N of physiological brain signals; calculating a minimum norm of a perturbation on the state transition matrix that causes the network to transition from a stable state to an unstable state; and assigning a fragility metric to each of the plurality N of physiological brain signals based on the minimum norm of the perturbation for that physiological brain signal.

Abstract: One aspect of the present disclosure relates to a stereotactic guide assembly comprising an implantable body and a fastener. The implantable body can have an interior chamber and a first passageway that extends through the implantable body into communication with the interior chamber. At least a portion of the interior chamber can be defined by a first coupling feature. The fastener can be configured to fit in the interior chamber. The fastener can have a second passageway extending therethrough, and a second coupling feature adapted to releasably engage the first coupling feature.

Abstract: Systems and methods for configuring a stereo-electroencephalography to target specific brain regions that are part of large scale neural networks responsible for neurological disorders are described. A hypothesis related to a large scale neural network responsible for a neurological disorder within patient's brain can be received. Coordinates for implantation of at least two depth electrodes in the patient's brain can be determined based on the hypothesis. Electrodes to be implanted can be selected for each of the coordinates. The electrodes can be designed and used to target these specific brain regions, including an insula electrode, a parietal-frontal electrode, a hippocampo electrode, and a perisylvian electrode. A visualization that includes the coordinates and the selected electrodes can be displayed, so that a surgeon can implant the selected electrodes into the patient's brain according to the coordinates to test the hypothesis.

Abstract: The present disclosure relates generally to implanting intracranial devices (e.g., electrodes, catheters, biopsy probes, etc.) independently (not in parallel) into a patient's brain. A single entry point can be opened in a patient's head. At least two intracranial devices can be inserted through the entry point. The at least two intracranial devices can be implanted to at least two different locations in the patient's brain through the same entry point.

Abstract: This disclosure relates to forming a lesion in a patient's neurological tissue without requiring general anesthesia. The lesion can be either temporary or permanent. In either case, the lesion can be created by a steerable probe that includes a steerable guide, a laser device, and at least one electrode. The steerable guide steers the probe to a target location in the subject's neurological tissue. When the probe reaches the target location, the laser can create the lesion. The at least one electrode can detect a progressive vanishing of neural activity from the portion of the neurological tissue due to the lesion.

Abstract: This disclosure relates to using stereo-thermo-lesioning (STL) to create lesions at one or more locations in the patient's nervous system at the patient's bedside without general anesthesia. A method that uses STL to treat a patient's neurological condition includes: using a plurality of stereotactically-implanted thermo-coupled multi-contact electrodes to record conduction data within a predetermined theoretical zone of activity within the patient's neurological tissue; detecting abnormal neurological activity of a neurological condition within the conduction data and localize a portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity; creating a lesion at the portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity using at least one contact of the plurality of thermo-coupled multi-contact electrodes.

Abstract: The present disclosure relates generally to automating the task of assignment of labels to identify electrical elements (e.g., electrode contacts, electrodes including a plurality of electrode contacts, and/or non-addressable electrical elements, like wires). A system that can automate the task of assignment of labels can include an electrical element, a microelectronic circuit associated with the electrical element, and an acquisition system. The microelectronic circuit can transmit a sequence comprising a label corresponding to the electrical element. The acquisition system can assign the label corresponding to the electrical element to a recording channel after decoding the sequence.

Abstract: The present disclosure relates generally to automating the task of assignment of labels to identify electrical elements (e.g., electrode contacts, electrodes including a plurality of electrode contacts, and/or non-addressable electrical elements, like wires). A system that can automate the task of assignment of labels can include an electrical element, a microelectronic circuit associated with the electrical element, and an acquisition system. The microelectronic circuit can transmit a sequence comprising a label corresponding to the electrical element. The acquisition system can assign the label corresponding to the electrical element to a recording channel after decoding the sequence.

Abstract: The present disclosure relates generally to precise stereotactic implantation of an instrument (e.g., a recording electrode, a stimulating electrode, a biopsy instrument, a catheter, a delivery device, and the like) into a target area in a patient's brain. As such, one aspect of the present disclosure can relate to a stereotactic device that can be used to accomplish the precise implantation of the instrument. The stereotactic device can include a body to secure the stereotactic device to the patient's head. In some instances, the body can have a u-shape. The stereotactic device can also include a guide attached between sides of the body to move an instrument holder into place above a target area. The guide can be locked in position to lock the instrument holder in the place to facilitate injection of the instrument into the target area.

Abstract: One aspect of the present disclosure relates to a stereotactic guide assembly comprising an implantable body and a fastener. The implantable body can have an interior chamber and a first passageway that extends through the implantable body into communication with the interior chamber. At least a portion of the interior chamber can be defined by a first coupling feature. The fastener can be configured to fit in the interior chamber. The fastener can have a second passageway extending therethrough, and a second coupling feature adapted to releasably engage the first coupling feature.

Abstract: A method of affecting a sleep disorder in a subject having the sleep disorder and a method of affecting a normal awakeness-sleep cycle in a subject having an abnormal awakeness-sleep cycle, said methods comprising: a) identifying at least one nucleus in a brain of the subject, said nucleus being a nucleus of the sleep circuitry of the brain; and b) stimulating the at least one identified nucleus so as to modulate the nucleus, thereby affecting the sleep disorder.

Abstract: A multiline PCM interface for signal processing is of particular application in cordless digital telephony, type DECT, with echo cancelling and ADPCM type voice encoding. The interface incorporates a set of ADPCM encoders (COD) and ADPCM decoders (DEC), digital-to-analogue (D/A) converters and analogue-to-digital converters (A/D). The outputs of the ADPCM decoders (DEC) and the analogue-to-digital converters (A/D) are joined to form a PCM output bus (BPO), the inputs of the digital-to-analogue (D/A) converters and ADPCM encoders (COD) are joined together to form a PCM input bus (PI). The interface also includes signal processing means (MSP) which receive data bursts from the PCM output bus (BPO) and applies these same bursts to the PCM input bus (PI) with a delay of one frame and echo-free. A synchronism generator (SYGEN) allocates consecutive time slots to converters involved in the same conversation, which therefore employ the same signal processor (DSP) to perform associated conference operations.