Abstract: A system for determining a user's interactions with an item within an interaction environment is described.

Abstract: Embodiments of the disclosure include methods and compositions related to treating an individual for HER2+ positive cancer with an appropriate treatment based on outcome of a multiparameter classifier. The methods allow for identification of HER2+ individuals that are suitable to avoid chemotherapy, in specific embodiments. Methods of the disclosure also allow for identification of HER2+ individuals that should not avoid chemotherapy. In specific embodiments, the multiparameter classifier identifies whether there is (1) a ratio of HER2 amplification, relative to a control probe, of greater than or equal to 4.5; (2) a HER2 expression level score of 3+, as determined by immunohistochemistry, in at least 90% of breast cancer cells; (3) whether there is a HER2-enriched molecular subtype; and (4) whether the individual has a wildtype PIKC3A gene.

Abstract: The invention relates to the use of tissue specific transcription factor-nucleosome adducts or transcription cofactor-nucleosome adducts as biomarkers in a biological fluid for the detection or diagnosis of a cancer in a subject. The invention further relates to using said tissue specific transcription factor or cofactor adducts to identify the site of development of a cancer in a subject.

Abstract: Managing multi-threaded computer processing, including: processing a main thread for an object in background of the multi-threaded computer processing without locking the object during its process in the background, wherein processing a main thread includes: monitoring the state of the object, wherein the object is deemed ready for processing after it satisfies a set of rules to check for its completeness, and the object has not been modified for a pre-determined period of time; creating and adding tasks to a queue for processing once the object is ready; and packaging required information for the tasks into a single data structure that is passed to a task thread and returned to the main thread upon completion.

Abstract: Managing multi-threaded computer processing, including: processing a main thread for an object in background of the multi-threaded computer processing without locking the object during its process in the background, wherein processing a main thread includes: monitoring the state of the object, wherein the object is deemed ready for processing after it satisfies a set of rules to check for its completeness, and the object has not been modified for a pre-determined period of time; creating and adding tasks to a queue for processing once the object is ready; and packaging required information for the tasks into a single data structure that is passed to a task thread and returned to the main thread upon completion.