Patents by Inventor Jorge Fischbarg

Jorge Fischbarg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5940307
    Abstract: The present invention relates to a method for predicting the tendency of a protein to form amphiphilic .alpha. or .beta. structure, wherein a series of values for U are calculated for spans of x residues, where the equationU.sub..alpha.x =H.sub.x +.mu..sub..alpha.x -<pt>is used to predict regions of amphiphilic .alpha. structure and the equationU.sub..beta.x =H.sub.x +.mu..sub..beta.x <pt>is used to predict regions of amphiphilic .beta. structure, and where H.sub.x is the average hydrophobicity for a span of x residues, .mu..sub.x is the hydrophobic moment, and <pt> is the position dependent turn propensity. When the values for U.sub..alpha.x and U.sub..beta.x are represented graphically, peaks are predicted to represent regions of .alpha. and .beta. structure, respectively.
    Type: Grant
    Filed: December 14, 1994
    Date of Patent: August 17, 1999
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jorge Fischbarg, Ferenc Czegledy, Pavel Iserovich, Jun Li, Min Cheung
  • Patent number: 4959355
    Abstract: This invention provides a method of inhibiting osmotic water flow across mammalian cell membranes which involves contacting the water channels of the cell membranes with an effective amount of a glucose transport blocker or of digitonin so as to inhibit osmotic water flow across the membranes.Additionally, this invention provides a method of treating a subject afflicted with a condition associated with abnormal osmotic water flow across cell membranes which comprises administering to the subject an effective amount of a glucose transport blocker or of digitonin so as to contact the water channels of the subject's cell membranes and inhibit osmotic water flow across the membranes.
    Type: Grant
    Filed: March 16, 1987
    Date of Patent: September 25, 1990
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jorge Fischbarg, Larry S. Liebovitch, Jan P. Koniarek