Abstract: A stentless bioprosthetic valve includes at least one piece of biocompatible material comprising a bi-leaflet conduit having a proximal end and a distal end. The proximal end defines a first annulus for suturing to the valve annulus. The conduit includes first and second leaflets that mimic the native leaflets and extend between the conduit ends. The distal end defines a second annulus at which the first and second leaflets terminate. The conduit further includes first and second pairs of prosthetic chordae projecting from the leaflets at the second annulus. One of the first pair of prosthetic chordae extends from the first leaflet and has a distal end for suturing to a papillary muscle and the other of the first pair of prosthetic chordae extends from the first leaflet and has a distal end for suturing to another papillary muscles.

Abstract: A stentless bioprosthetic valve includes at least one piece of biocompatible material comprising a bi-leaflet conduit. The conduit has a distal end and a proximal end that defines a first annulus for suturing to the valve annulus of a heart. The conduit further includes first and second leaflets that mimic the anterior and posterior leaflets of the native mitral valve. The first and second leaflets extend between the proximal and distal ends. The distal end defines a second annulus at which the first and second leaflets terminate. The second annulus is for suturing to free edges of the anterior and posterior leaflets of the native mitral valve that remain intact following resection of the native mitral valve so that the native chordae tendineae continue to provide prolapse prevention and left ventricular muscle support functions in addition to maintaining the continuity between the valve annulus and the papillary muscles.

Abstract: A stentless bioprosthetic valve includes at least one piece of biocompatible material comprising a bi-leaflet conduit having a proximal end and a distal end. The proximal end defines a first annulus for suturing to the valve annulus in the heart. The conduit includes first and second leaflets that mimic the native anterior and posterior leaflets and extend between the ends of the conduit. The distal end defines a second annulus at which the first and second leaflets terminate. The conduit further includes first and second pairs of prosthetic chordae projecting from the leaflets at the second annulus. Each of the prosthetic chordae comprises a solid uninterrupted extension of the piece of biocompatible material.

Abstract: A stentless bioprosthetic valve includes at least one piece of biocompatible material comprising a bi-leaflet conduit. The conduit has a distal end and a proximal end that defines a first annulus for suturing to the valve annulus of a heart. The conduit further includes first and second leaflets that mimic the anterior and posterior leaflets of the native mitral valve. The first and second leaflets extend between the proximal and distal ends. The distal end defines a second annulus at which the first and second leaflets terminate. The second annulus is for suturing to free edges of the anterior and posterior leaflets of the native mitral valve that remain intact following resection of the native mitral valve so that the native chordae tendinae continue to provide prolapse prevention and left ventricular muscle support functions in addition to maintaining the continuity between the valve annulus and the papillary muscles.

Abstract: A perfusion cannula having a proximal section configured for attachment to a source of perfusion fluid, and a distal section configured for insertion in a blood vessel for delivering perfusion fluid to the blood vessel. In one embodiment, the cannula generally comprises a shaft having a proximal end, a distal end, a distal shaft section, and a proximal shaft section which is connected to the distal shaft section between the proximal and distal ends of the distal shaft section such that an acute angle is formed between the proximal shaft section and the proximal end of the distal shaft section. A lumen in the elongated shaft extends within the proximal shaft section and the distal shaft section to and in fluid communication with a port in the distal end of the distal shaft section. The lumen is configured for delivery of fluid, and may be configured for slidably receiving a guidewire therein.