Abstract: The present invention relates to a method for the production of d-erythro-sphingosine and analogs thereof, wherein the method comprises a step of condensing a compound of formula (2): or a salt thereof, wherein R1 is hydrogen, a C1-50 alkyl, preferably a C1-15 alkyl, more preferably a C10-15 alkyl, which may be saturated or contain one or more double and/or triple bonds, and/or which may contain one or more functional groups, the functional group being preferably selected from the group consisting of an alkoxy group, a secondary, or tertiary amine, a thioether, an acyloxy group, an acylamido group, a phosphorus containing functional group, a carboxyl group, or a carbonyl group, with a compound of formula (3): wherein the bond represents a double or a single bond, W is C, or C(OR4), Z is O, or OR5, provided that: when W is C, the bond is a double bond and Z is O, or when W is C(OR4), the bond is a single bond and Z is OR5, and wherein R2 and R3 are independently selected from a saturate

Abstract: The present invention relates to a computer-implemented method capable of automatically classifying and differentiating biliary lesions in images obtained from a digital cholangioscopy system, characterizing them according to their malignant potential, through the classification of pixels as a malignant lesion, or benign lesion, followed by a characterization stage and indexing of such lesions according to a set of morphologic characteristics with clinical relevance, namely the presence/absence of tumor vessels, the presence/absence of papillary projections, the presence/absence of intraductal nodules and the presence/absence of tumor masses.

Abstract: The present disclosure relates to a release composition comprising a protein and an active agent, wherein the active agent is released when in presence of an electrolyte solution. A kit and an article comprising the release composition of the present-subject matter are also encompassed.

Abstract: Systems and methods are provided for a personalized entity repository. For example, a computing device comprises a personalized entity repository having fixed sets of entities from an entity repository stored at a server, a processor, and memory storing instructions that cause the computing device to identify fixed sets of entities that are relevant to a user based on context associated with the computing device, rank the fixed sets by relevancy, and update the personalized entity repository using selected sets determined based on the rank and on set usage parameters applicable to the user. In another example, a method includes generating fixed sets of entities from an entity repository, including location-based sets and topic-based sets, and providing a subset of the fixed sets to a client, the client requesting the subset based on the client's location and on items identified in content generated for display on the client.

Abstract: This disclosure relates to an intermolecularly-fabricated composition for capturing plant materials, agrochemicals and pharmaceuticals which can simultaneously capture inorganic particulates and organic compounds in which the capture materials have mutual chemical affinity with the composition matrix thereby exhibiting an adhesive property.

Abstract: Systems and methods are provided for a personalized entity repository. For example, a computing device comprises a personalized entity repository having fixed sets of entities from an entity repository stored at a server, a processor, and memory storing instructions that cause the computing device to identify fixed sets of entities that are relevant to a user based on context associated with the computing device, rank the fixed sets by relevancy, and update the personalized entity repository using selected sets determined based on the rank and on set usage parameters applicable to the user. In another example, a method includes generating fixed sets of entities from an entity repository, including location-based sets and topic-based sets, and providing a subset of the fixed sets to a client, the client requesting the subset based on the client's location and on items identified in content generated for display on the client.

Abstract: It is therefore an object of the present invention a multi-convolutional two-dimensional (2D) attention unit to be applied in performing MTS three-dimensional (3D) data analysis, of input data (1) with cyclic properties, using an RRN architecture. This unit is able to constructs one independent attention vector a per variable of the MTS using 2D convolutional operations to capture the importance of a time-step inside surrounding segments and time-steps area. For that purpose, the two-dimensional attention unit is comprised by a splitting block (2), a attention block (3), a concatenation block (4) and a scaling block (5).

Abstract: Technologies are described herein for a user interface uniting two primary components, a list view and a reading pane, within a message reading application. Technologies are also described for synchronizing status and parameters between the two primary user interface components. In particular, a user interface for reading messages can represent all components of a conversation with both a list view for presenting a message map, and a reading pane for presenting a content view. The list view can present a list of messages grouped by conversation. The reading pane window can contain smaller windows or frames. Each of the smaller windows or frames can contain a message within a given conversation. Synchronization provided between the list view and a reading pane can allow message selection in one of the user interface components to cause display and selection of the corresponding message in the other user interface component.

Abstract: This invention relates to atroipsomers of reduced tetraphenylporphyrin derivatives with halogen atoms (F, Cl, Br) in the ortho positions of the phenyl groups, particularly halogenated tetraphenylchlorins and halogenated tetraphenylbacteriochlorins, which can be used in photodynamic therapy. According to the formulae of the invention, the ortho-phenyl substituents X1, X2, X3, X4, X5, X6, X7 and X8 may be identical or different and represent halogen atoms or hydrogen atoms, provided that at least all of X2, X4, X6 and X8 are halogens, and the meta-phenyl substituents R1, R2, R3 and R4 are independently chosen from —OH, —OR or —SO2R?, where R? are each independently chosen from —Cl, —OH, -aminoacid, —OR, —NHR, or —NR2, where R are alkyl of 1 to 12 carbon atoms or R2 represents cycloalkyl with 2 to 12 carbon atoms. The atropisomers of this invention have the majority of the substituents R1, R2, R3 and R4 on the same side of the plane defined by the macrocycle.

Abstract: Systems and methods are provided for a personalized entity repository. For example, a computing device comprises a personalized entity repository having fixed sets of entities from an entity repository stored at a server, a processor, and memory storing instructions that cause the computing device to identify fixed sets of entities that are relevant to a user based on context associated with the computing device, rank the fixed sets by relevancy, and update the personalized entity repository using selected sets determined based on the rank and on set usage parameters applicable to the user. In another example, a method includes generating fixed sets of entities from an entity repository, including location-based sets and topic-based sets, and providing a subset of the fixed sets to a client, the client requesting the subset based on the client's location and on items identified in content generated for display on the client.

Abstract: The present disclosure relates to a novel sericin-based hydrogel wherein the silk sericin is enzymatically cross-linked for an improved treatment of wound healing, ischemic diseases or cardiovascular diseases, namely chronic wound healing, in particular diabetic wound.

Abstract: Systems and methods are provided for a personalized entity repository. For example, a computing device comprises a personalized entity repository having fixed sets of entities from an entity repository stored at a server, a processor, and memory storing instructions that cause the computing device to identify fixed sets of entities that are relevant to a user based on context associated with the computing device, rank the fixed sets by relevancy, and update the personalized entity repository using selected sets determined based on the rank and on set usage parameters applicable to the user. In another example, a method includes generating fixed sets of entities from an entity repository, including location-based sets and topic-based sets, and providing a subset of the fixed sets to a client, the client requesting the subset based on the client's location and on items identified in content generated for display on the client.

Abstract: Technologies are described herein for a user interface uniting two primary components, a list view and a reading pane, within a message reading application. Technologies are also described for synchronizing status and parameters between the two primary user interface components. In particular, a user interface for reading messages can represent all components of a conversation with both a list view for presenting a message map, and a reading pane for presenting a content view. The list view can present a list of messages grouped by conversation. The reading pane window can contain smaller windows or frames. Each of the smaller windows or frames can contain a message within a given conversation. Synchronization provided between the list view and a reading pane can allow message selection in one of the user interface components to cause display and selection of the corresponding message in the other user interface component.

Abstract: Technologies are described herein for a user interface uniting two primary components, a list view and a reading pane, within a message reading application. Technologies are also described for synchronizing status and parameters between the two primary user interface components. In particular, a user interface for reading messages can represent all components of a conversation with both a list view for presenting a message map, and a reading pane for presenting a content view. The list view can present a list of messages grouped by conversation. The reading pane window can contain smaller windows or frames. Each of the smaller windows or frames can contain a message within a given conversation. Synchronization provided between the list view and a reading pane can allow message selection in one of the user interface components to cause display and selection of the corresponding message in the other user interface component.

Abstract: A method of processing a query on a genome to produce a report is disclosed. The method comprises receiving a first secret, a second secret and a query request over a communications network during a first communications session and storing a proxy value associated with the query request in a database. The first secret is used to determine a genome key enabling access to genome data stored in the database and associated with the first secret. The proxy value and a query key are associated using the second secret such that the query key can only be found using both the proxy value and the second secret. An association is stored between the genome key and the query key in the database and the first and second secrets are deleted subsequent to determining the genome key and associating the proxy value and query key, during or at the end of the first communications session, to ensure anonymity.

Abstract: Systems and methods are provided for a personalized entity repository. For example, a computing device comprises a personalized entity repository having fixed sets of entities from an entity repository stored at a server, a processor, and memory storing instructions that cause the computing device to identify fixed sets of entities that are relevant to a user based on context associated with the computing device, rank the fixed sets by relevancy, and update the personalized entity repository using selected sets determined based on the rank and on set usage parameters applicable to the user. In another example, a method includes generating fixed sets of entities from an entity repository, including location-based sets and topic-based sets, and providing a subset of the fixed sets to a client, the client requesting the subset based on the client's location and on items identified in content generated for display on the client.

Abstract: This washing machine for a railway vehicle includes a water texturing system, mixing water with particles able to produce textured water having super-hydrophoby properties making it possible to implement a lotus cleaning effect on the surface on which the textured water flows; a textured water spraying system, fed by the water texturing system and using at least one appropriate spraying device to spray the textured water on a surface of the railway vehicle to be cleaned.

Abstract: Various technologies and techniques are disclosed that improve the workflow process for resolving data elements, such as email addresses. These technologies and techniques allow the user to perform such tasks in the same context as the activity or message. In addition, user can start and stop the resolution process at any point in the process of composing the activity or email. The activity cannot be finalized, such as an email message being sent, until all of the data elements are resolved.

Abstract: The present invention relates to carboxamide halogenated porphyrin derivatives, in particular bacteriochlorin or chlorin, of formula (I) use of the same or a pharmaceutically acceptable salt thereof in photodynamic therapy, where the derivatives are able to detect and exhibit the presence of hyperproliferative disorders and, in the presence of an adequate lighting, to treat the same. The present invention also describes a pharmaceutical composition having the carboxamide halogenated porphyrin derivatives, in particular bacteria-chlorin or chlorin, of Formula (I) or a pharmaceutically acceptable salt thereof, for the treatment of cancer and/or microbial and/or viral infections, in humans or animals.

Abstract: The present disclosure relates to a novel sericin-based hydrogel wherein the silk sericin is enzymatically cross-linked for an improved treatment of wound healing, ischemic diseases or cardiovascular diseases, namely chronic wound healing, in particular diabetic wound.