Abstract: The present invention relates to the use of 2-hydroxy or 2-acetyloxy-4-trifluoromethylbenzoic acid, respectively, for the treatment or prevention of mild cognitive impairment (MCI) in mammals, especially in human beings. Futhermore, the present invention also concerns the use of 2-hydroxy or 2-acetyloxy-4-trifluoromethylbenzoic acid, respectively, for delaying or preventing the conversion of MCI into dementia, especially Alzheimer's Disease.

Abstract: An applicator for semi-solid medications comprises a tubular body (20) having a rounded dispensing end (21) provided with at least one opening (26) and a grasping end (22), the inner surface of a proximal portion of said tubular body defining a reservoir for the medication, a plunger (30), initially housed inside the tubular body, which plunger is provided with a rod (31) and grasping means (33), a piston (40), positioned in sealing contact with the inner surface of said tubular body providing a closure for the medication reservoir, wherein said piston has a longitudinal hole (45) through which rod (31) of the plunger is disposed, and wherein said piston initially abuts on a stop means (25) when the applicator is received by the user, a coupling means (35, 46) between rod (31) and piston (40), a closure means for sealingly closing off said opening (26) on said dispensing end, wherein the plunger (30) is extractable from the tubular body until the rod (31) becomes engaged with the piston (40) by the coupling m