Patents by Inventor José Ángel Ramón Hernández

José Ángel Ramón Hernández has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical composition of microspheres for preventing diabetic foot amputation
    Patent number: 8741848
    Abstract: The present invention relates to a pharmaceutical composition that comprises polymeric microspheres containing epidermal growth factor (EGF) for the application, by the parenteral route, into the lower limbs of diabetic patients with cutaneous chronic ischemic ulcerative wounds. The pharmaceutical composition described herein, in contrast with the state of the art, is useful because reduce the administration frequency during the treatment and allows for the healing of the ulcerative wounds in a shorter time interval with respect to the injection of equivalent quantities of non-encapsulated EGF.
    Type: Grant
    Filed: January 29, 2007
    Date of Patent: June 3, 2014
    Assignee: Centro de Ingenieria Genetica y Biotecnologia
    Inventors: Vivian Maria Sáez Martinez, Rolando Páez Meireles, Jorge Amador Berlanga Acosta, Blas Yamir Betancourt Rodriguez, José Ángel Ramón Hernández
  • Four branched dendrimer-PEG for conjugation to proteins and peptides
    Patent number: 8703893
    Abstract: A polymeric dendrimer-like structure with four branches of monomethoxy-polyethylene glycol that can be represented as: The carboxylic group of the previous structure can be functionalized for the production of conjugates of pharmaceutical interest. The binding of this dendrimer-like polyethylene glycol to therapeutic proteins improves their in vitro and in vivo stability.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: April 22, 2014
    Assignee: Centro de Ingenienia Genetica y Biotecnologia
    Inventors: José Ángel Ramón Hernández, Fidel Raúl Castro Odio, Vivian-María Sáez Martinez, Rolando Páez Meircles, Eduardo Fernández Sánchez
  • PHARMACEUTICAL COMPOSITION OF MICROSPHERES FOR PREVENTING DIABETIC FOOT AMPUTATION
    Publication number: 20090220608
    Abstract: The present invention relates to a pharmaceutical composition that comprises polymeric microspheres containing epidermal growth factor (EGF) for the application, by the parenteral route, into the lower limbs of diabetic patients with cutaneous chronic ischemic ulcerative wounds. The pharmaceutical composition described herein, in contrast with the state of the art, is useful because reduce the administration frequency during the treatment and allows for the healing of the ulcerative wounds in a shorter time interval with respect to the injection of equivalent quantities of non-encapsulated EGF.
    Type: Application
    Filed: January 29, 2007
    Publication date: September 3, 2009
    Inventors: Vivian Maria Sáez Martinez, Rolando Páez Meireles, Jorge Amador Berlanga Acosta, Blas Yamir Betancourt Rodriguez, José Ángel Ramón Hernández
  • FOUR BRANCHED DENDRIMER-PEG FOR CONJUGATION TO PROTEINS AND PEPTIDES
    Publication number: 20090082537
    Abstract: A polymeric dendrimer-like structure with four branches of monomethoxy-polyethylene glycol that can be represented as: The carboxylic group of the previous structure can be functionalized for the production of conjugates of pharmaceutical interest. The binding of this dendrimer-like polyethylene glycol to therapeutic proteins improves their in vitro and in vivo stability.
    Type: Application
    Filed: November 20, 2006
    Publication date: March 26, 2009
    Inventors: Jose Angel Ramon Hernandez, Fedel Raul Castro Odio, Vivian Maria Saez Martinez, Rolando Paez Meireles, Eduardo Fernandez Sanchez