Patents by Inventor Jose Aron Lopez

Jose Aron Lopez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein stabilizing factors
    Patent number: 10806695
    Abstract: Compositions and methods are described for preventing or reducing protein loss due to protein aggregation, denaturation, and absorption to surfaces. Also described are compositions and methods for preventing or reducing the fouling or clogging of medical devices that come into contact with blood, such as catheters. Also described are methods to treat diseases caused by activation of the microvasculature.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: October 20, 2020
    Assignee: BLOODWORKS
    Inventors: Dominic W. Chung, Jose Aron Lopez, Minhua Ling, Junmei Chen, Xiaoyun Fu
  • DETERMINATION OF SMALL-MOLECULE THIOLS AND DISULFIDES: PROTEIN BOUND CYS AND TOTAL CYSTEINE AS BIOMARKERS OF OXIDATIVE STRESS
    Publication number: 20200319199
    Abstract: Compositions and methods for determining the level of thiol and disulfide containing molecules in a sample are provided. The compositions and methods can be used to determine the level of oxidative stress in a subject with or without antioxidant treatment. Also provided are biomarkers of oxidative stress.
    Type: Application
    Filed: June 18, 2020
    Publication date: October 8, 2020
    Applicant: BLOODWORKS
    Inventors: Xiaoyun Fu, Shelby A. Cate, Jose Aron Lopez, Junmei Chen, Barbara A. Konkle
  • Determination of small-molecule thiols and disulfides: protein bound cys and total cysteine as biomarkers of oxidative stress
    Patent number: 10705093
    Abstract: Compositions and methods for determining the level of thiol and disulfide containing molecules in a sample are provided. The compositions and methods can be used to determine the level of oxidative stress in a subject with or without antioxidant treatment. Also provided are biomarkers of oxidative stress.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: July 7, 2020
    Assignee: Bloodworks
    Inventors: Xiaoyun Fu, Shelby A. Cate, Jose Aron Lopez, Junmei Chen, Barbara A. Konkle
  • Protein stabilizing factors
    Patent number: 10441531
    Abstract: Compositions and methods are described for preventing or reducing protein loss due to protein aggregation, denaturation, and adsorption to surfaces. Also described are compositions and methods for preventing or reducing the fouling or clogging of medical devices that come into contact with blood, such as catheters. Also described are methods to treat diseases caused by activation of the microvasculature.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: October 15, 2019
    Assignee: Bloodworks
    Inventors: Dominic Chung, Jose Aron Lopez, Minhua Ling, Junmei Chen, Xiaoyun Fu
  • PROTEIN STABILIZING FACTORS
    Publication number: 20190216723
    Abstract: Compositions and methods are described for preventing or reducing protein loss due to protein aggregation, denaturation, and absorption to surfaces. Also described are compositions and methods for preventing or reducing the fouling or clogging of medical devices that come into contact with blood, such as catheters. Also described are methods to treat diseases caused by activation of the microvasculature.
    Type: Application
    Filed: April 2, 2019
    Publication date: July 18, 2019
    Applicant: Bloodworks
    Inventors: Dominic W. Chung, Jose Aron Lopez, Minhua Ling, Junmei Chen, Xiaoyun Fu
  • Determination of Small-Molecule Thiols And Disulfides: Protein Bound Cys and Total Cysteine as Biomarkers of Oxidative Stress
    Publication number: 20170219598
    Abstract: Compositions and methods for determining the level of thiol and disulfide containing molecules in a sample are provided. The compositions and methods can be used to determine the level of oxidative stress in a subject with or without antioxidant treatment. Also provided are biomarkers of oxidative stress.
    Type: Application
    Filed: July 27, 2015
    Publication date: August 3, 2017
    Inventors: Xiaoyun Fu, Shelby A. Cate, Jose Aron Lopez, Junmei Chen, Barbara A. Konkle
  • Protein Stabilizing Factors
    Publication number: 20150320909
    Abstract: Compositions and methods are described for preventing or reducing protein loss due to protein aggregation, denaturation, and absorption to surfaces. Also described are compositions and methods for preventing or reducing the fouling or clogging of medical devices that come into contact with blood, such as catheters. Also described are methods to treat diseases caused by activation of the microvasculature.
    Type: Application
    Filed: November 12, 2013
    Publication date: November 12, 2015
    Inventors: Dominic Chung, Jose Aron Lopez, Minhua Ling, Junmei Chen, Xiaoyun Fu
  • Determination of von Willebrand Factor cleavage by ADAMTS13
    Patent number: 8637268
    Abstract: Novel methods are described for measuring the rate of ADAMTS13-mediated cleavage of von Willebrand Factor (VWF) multimers. Through the use of the reagent, ristocetin, the method can advantageously be performed in the absence of an applied shear stress or added denaturing agent. Also described are methods for diagnosing ADAMTS13-associated disorders and methods for providing improved treatment of those disorders by evaluating the efficacy of the treatment using the methods as described.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: January 28, 2014
    Assignee: Puget Sound Blood Center
    Inventors: Junmei Chen, Dominic W. Chung, Jose Aron Lopez
  • Enhanced Cleavage of Von Willebrand Factor by ADAMTS13
    Publication number: 20120142036
    Abstract: Novel methods are described for measuring the rate of ADAMTS13-mediated cleavage of von Willebrand Factor (VWF) multimers. Through the use of the reagent, ristocetin, the method can advantageously be performed in the absence of an applied shear stress or added denaturing agent. Also described are methods for diagnosing ADAMTS13-associated disorders and methods for providing improved treatment of those disorders by evaluating the efficacy of the treatment using the methods as described.
    Type: Application
    Filed: November 4, 2011
    Publication date: June 7, 2012
    Inventors: Junmei Chen, Dominic W. Chung, Jose Aron Lopez