Patents by Inventor Jose G. Venegas
Jose G. Venegas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220031976Abstract: A system and method for providing a therapy to a subject may include a lumen configured to be coupled to a portion of a respiration passage of the subject to receive air respired by the subject. A sensor is configured to monitor the lumen and generate a signal based on the air respired by the subject. A pressure pulse delivery system is configured to deliver a pressure pulse along the lumen to the subject and a reservoir of therapeutic agent is coupled to the lumen. A processor is configured to receive the signal from the sensor, determine, from at least the signal, an exhalation period of the subject, and based on the exhalation period, cause the pressure pulse delivery system to deliver a pressure pulse to the subject. Following the pressure pulse, the processor can cause the therapeutic agent to be delivered from the reservoir.Type: ApplicationFiled: February 26, 2021Publication date: February 3, 2022Inventors: Elliot E. Greenblatt, Jose G. Venegas
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Patent number: 10953169Abstract: A system and method for providing a therapy to a subject may include a lumen configured to be coupled to a portion of a respiration passage of the subject to receive air respired by the subject. A sensor is configured to monitor the lumen and generate a signal based on the air respired by the subject. A pressure pulse delivery system is configured to deliver a pressure pulse along the lumen to the subject and a reservoir of therapeutic agent is coupled to the lumen. A processor is configured to receive the signal from the sensor, determine, from at least the signal, an exhalation period of the subject, and based on the exhalation period, cause the pressure pulse delivery system to deliver a pressure pulse to the subject. Following the pressure pulse, the processor can cause the therapeutic agent to be delivered from the reservoir.Type: GrantFiled: November 19, 2014Date of Patent: March 23, 2021Assignee: The General Hospital CorporationInventors: Elliot E. Greenblatt, Jose G. Venegas
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Patent number: 10926053Abstract: Described here are closed-circuit breathing devices and methods for their use. In general, the closed-circuit breathing device is configured to achieve a steady-state equilibrium, whereby therapeutic gas is introduced into the breathing circuit in small, controlled volumes until a steady state concentration of the therapeutic gas is reached. During this time, the closed-circuit breathing device is operated in a true closed circuit, such that the therapeutic gas is not lost to the atmosphere. Safety measures are built into the closed-circuit breathing device so that a hypoxic mixture is not delivered to the subject. The therapeutic gas may be xenon.Type: GrantFiled: November 20, 2015Date of Patent: February 23, 2021Assignee: The General Hospital CorporationInventor: Jose G. Venegas
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Publication number: 20170259023Abstract: Described here are closed-circuit breathing devices and methods for their use. In general, the closed-circuit breathing device is configured to achieve a steady-state equilibrium, whereby therapeutic gas is introduced into the breathing circuit in small, controlled volumes until a steady state concentration of the therapeutic gas is reached. During this time, the closed-circuit breathing device is operated in a true closed circuit, such that the therapeutic gas is not lost to the atmosphere. Safety measures are built into the closed-circuit breathing device so that a hypoxic mixture is not delivered to the subject. The therapeutic gas may be xenon.Type: ApplicationFiled: November 20, 2015Publication date: September 14, 2017Inventor: Jose G. VENEGAS
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Publication number: 20160287819Abstract: A system and method for providing a therapy to a subject may include a lumen configured to be coupled to a portion of a respiration passage of the subject to receive air respired by the subject. A sensor is configured to monitor the lumen and generate a signal based on the air respired by the subject. A pressure pulse delivery system is configured to deliver a pressure pulse along the lumen to the subject and a reservoir of therapeutic agent is coupled to the lumen. A processor is configured to receive the signal from the sensor, determine, from at least the signal, an exhalation period of the subject, and based on the exhalation period, cause the pressure pulse delivery system to deliver a pressure pulse to the subject. Following the pressure pulse, the processor can cause the therapeutic agent to be delivered from the reservoir.Type: ApplicationFiled: November 19, 2014Publication date: October 6, 2016Inventors: Elliot E. Greenblatt, Jose G. Venegas
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Patent number: 8527034Abstract: An input function indicative of a time-activity curve in pulmonary arterial plasma is produced from a series of PET image frames in lieu of manual blood sampling. Two manually acquired blood samples are input along with pixel values of a blood pool region of interest (ROI) in the PET image frames into a two-parameter model of the ROI's time-activity curve. In an iterative process the model converges to accurately indicate the amount of 18F-FDG tracer in the arterial blood. Pulmonary uptake of the tracer is assessed with the PET image frames and the calculated input function.Type: GrantFiled: July 11, 2007Date of Patent: September 3, 2013Assignee: The General Hospital CorporationInventors: Tobias Schroder, Marcos F. Vidal Melo, Guido Musch, Robert Scott Harris, Jose G. Venegas, Tilo Winkler
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Patent number: 8137302Abstract: The lateral flow between adjacent lung segments is occluded by blocking collateral flow channels with particles. A gas flow is established from one lung segment through the flow channels in an intermediate fibrous septum, and out through the adjacent lung segment. Particles entrained in the gas flow become lodged in the collateral flow channels to eventually block flow.Type: GrantFiled: March 12, 2007Date of Patent: March 20, 2012Assignee: Pulmonx CorporationInventors: Nikolai Aljuri, Jose G. Venegas, Ajit Nair, Rodney C. Perkins
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Publication number: 20090018438Abstract: An input function indicative of a time-activity curve in pulmonary arterial plasma is produced from a series of PET image frames in lieu of manual blood sampling. Two manually acquired blood samples are input along with pixel values of a blood pool region of interest (ROI) in the PET image frames into a two-parameter model of the ROI's time-activity curve. In an iterative process the model converges to accurately indicate the amount of 18F-FDG tracer in the arterial blood. Pulmonary uptake of the tracer is assessed with the PET image frames and the calculated input function.Type: ApplicationFiled: July 11, 2007Publication date: January 15, 2009Inventors: Tobias Schroder, Marcos F. Vidal Melo, Guido Musch, Robert Scott Harris, Jose G. Venegas, Tilo Winkler
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Publication number: 20080228130Abstract: The lateral flow between adjacent lung segments is occluded by blocking collateral flow channels with particles. A gas flow is established from one lung segment through the flow channels in an intermediate fibrous septum, and out through the adjacent lung segment. Particles entrained in the gas flow become lodged in the collateral flow channels to eventually block flow.Type: ApplicationFiled: March 12, 2007Publication date: September 18, 2008Applicant: PULMONxInventors: Nikolai Aljuri, Jose G. Venegas, Ajit Nair, Rodney C. Perkins
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Patent number: 5854423Abstract: The present invention, a thrombo visco-elastogram (TVE), measures the changes in blood elastic and viscous properties in the magnitude and phase of the hydro-dynamic impedance of a tubular blood sample as the thrombus is formed. The present invention is an apparatus and method for assessment of visco-elasticity and shear adherence strength properties of blood clots. An apparatus for practicing the invention includes a tubular conduit connected to a fluid-filled cylindrical chamber and a fluid-filled reservoir, a piezo-electric bender attached to the fluid-filled cylindrical chamber, which creates a volume variation in the fluid-filled cylindrical chamber, a fluid source capable of injecting a fluid into the tubular conduit, a blood source capable of injecting blood into the tubular conduit, and a microprocessor to supply a sinusoidal wave form or limited band frequency content signal to the piezo-electric bender and record and analyze resulting pressure signals.Type: GrantFiled: March 19, 1997Date of Patent: December 29, 1998Inventor: Jose G. Venegas
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Patent number: 5348879Abstract: Disclosed is a method for imparting to a living culture of cells biaxial mechanical forces which approximate the mechanical forces to which cells are subject in vivo. The method utilizes a displacement applicator which may be actuated to contact and stretch a membrane having a living cell culture mounted thereon. Stretching of the membrane imparts biaxial mechanical forces to the cells. These forces may be uniformly applied to the cells, or they may be selectively nonuniformly applied.Type: GrantFiled: February 19, 1993Date of Patent: September 20, 1994Assignees: The General Hospital Corporation, Massachusetts Institute of TechnologyInventors: Alan R. Shapiro, Martha L. Gray, Luis A. Melendez, Jonathan L. Schaffer, Wright John D., Jose G. Venegas
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Patent number: 5217899Abstract: Disclosed is an apparatus and method for imparting to a living culture of cells biaxial mechanical forces which approximate the mechanical forces to which cells are subjected in vivo. The apparatus includes a displacement applicator which may be actuated to contact and stretch a membrane having a living cell culture mounted thereon. Stretching of the membrane imparts biaxial mechanical forces to the cells. These forces may be uniformly applied to the cells, or they may be selectively non-uniformly applied.Type: GrantFiled: August 24, 1990Date of Patent: June 8, 1993Assignees: The General Hospital Corporation, Massachusetts Institute of TechnologyInventors: Alan R. Shapiro, Martha L. Gray, Luis A. Melendez, Jonathan L. Schaffer, John D. Wright, Jose G. Venegas
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Patent number: 5074297Abstract: A respirator mask assembly for use with intermittent positive pressure breathing treatments facilitates the formation and automatic intermittent adjustment of the seal between a patient's face and a facial unit of the respirator mask. The respirator mask assembly comprises a facial unit, an expandable piston adjacent the facial unit and a rigid support structure attached to one end of the piston, and an attachment mechanism for securing the mask assembly to a patient. During the inspiration portion of the ventilation cycle a positive pressure is developed within the mask assembly, causing the piston to expand. Because, the attachment mechanism and the support cooperate to resist significant expansion of the piston, a force is generated which presses the facial unit against the patient's face and maintains an air tight seal. When pressure within the masks unit decreases, the contact force on the facial unit is likewise decreased and the seal is eliminated.Type: GrantFiled: December 19, 1989Date of Patent: December 24, 1991Assignee: The General Hospital CorporationInventor: Jose G. Venegas
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Patent number: 5026348Abstract: An in-line fluid conduit condition analyzer which includes a chamber placed in the conduit flow path and having one wall forming a piezoceramic bender that varies the chamber volume (or pressure) according to a predetermined waveform or noise spectrum and an associated piezoceramic pressure or displacement sensor. The time derivative of the displacement or the pressure are analyzed under computer control to identify conduit abnormalities. In particular application to intravenous fluid administration to patients, the system is capable of distinguishing a number of abnormalities including cathether obstruction, catheter needle out of the vein, catheter needle into the vein, as well as fluid bubble presence or conduit disconnection.Type: GrantFiled: June 6, 1988Date of Patent: June 25, 1991Assignee: The General Hospital CorporationInventor: Jose G. Venegas
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Patent number: 4155356Abstract: Process and apparatus for assisting expiration of respiratory gas from the lungs and/or assisting pulmonary blood circulation. The apparatus comprises means for generating a series of pressure pulses and means for transmitting the pressure pulses to air passageways in the lungs through respiratory gas. The generating means can comprise a solenoid controlled pump, a solenoid controlled valve, or a reflector means for directing pulses into the lungs. The transmitting means preferable comprises a tube for placement in the trachea. The frequency, amplitude, and shape of the pressure waves are controlled to outwardly displace walls of collapsed air passageways in the lungs, to maintain the outward displacement, and to generate a pumping action to assist in respiration. Wave characteristics may be controlled manually or modulated by signals derived from an electrocardiogram and/or a pleural pressure sensing means.Type: GrantFiled: February 2, 1977Date of Patent: May 22, 1979Inventor: Jose G. Venegas