Publication number: 20060063228
Abstract: This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
Type:
Application
Filed:
June 9, 2005
Publication date:
March 23, 2006
Inventors:
Marion Kasaian, Lioudmila Tchistiakova, Geertruida Veldman, Kimberly Marquette, Xiang-Yang Tan, Debra Donaldson, Laura Lin, Tania Shane, Amy Tam, Eric Feyfant, Nancy Wood, Lori Fitz, Angela Widom, Kevin Parris, Samuel Goldman, Jose Saldanha