Patents by Inventor Josee Laganiere

Josee Laganiere has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for culturing and/or differentiating hematopoietic stem cells into progenitors and uses thereof
    Patent number: 11666600
    Abstract: The present description relates to in vitro methods for culturing hematopoietic stem cells (HSCs) under mild hyperthermia conditions (e.g., between 38° C. and 40° C.) in the presence of a pyrimidoindole derivative agonist of hematopoietic stem cell expansion. The combined use of mild hyperthermia and the pyrimidoindole derivative act synergistically to promote expansion of CD34+ HSCs and/or differentiation into progenitor cells (e.g., megakaryocytic progenitors). The present description also relates to in vitro expanded cell populations of HSCs and/or progenitors, as well as uses thereof in therapy (e.g., transplantation).
    Type: Grant
    Filed: September 29, 2020
    Date of Patent: June 6, 2023
    Assignee: HEMA-QUEBEC
    Inventors: Josée Laganière, Nellie Dumont
  • METHODS FOR CULTURING AND/OR DIFFERENTIATING HEMATOPOIETIC STEM CELLS INTO PROGENITORS AND USES THEREOF
    Publication number: 20210023131
    Abstract: The present description relates to in vitro methods for culturing hematopoietic stem cells (HSCs) under mild hyperthermia conditions (e.g., between 38° C. and 40° C.) in the presence of a pyrimidoindole derivative agonist of hematopoietic stem cell expansion. The combined use of mild hyperthermia and the pyrimidoindole derivative act synergistically to promote expansion of CD34+ HSCs and/or differentiation into progenitor cells (e.g., megakaryocytic progenitors). The present description also relates to in vitro expanded cell populations of HSCs and/or progenitors, as well as uses thereof in therapy (e.g., transplantation).
    Type: Application
    Filed: September 29, 2020
    Publication date: January 28, 2021
    Inventors: Josée Laganière, Nellie Dumont
  • Methods for culturing and/or differentiating hematopoietic stem cells into progenitors and uses thereof
    Patent number: 10828329
    Abstract: The present description relates to in vitro methods for culturing hematopoietic stem cells (HSCs) under mild hyperthermia conditions (e.g., between 38° C. and 40° C.) in the presence of a pyrimidoindole derivative agonist of hematopoietic stem cell expansion. The combined use of mild hyperthermia and the pyrimidoindole derivative act synergistically to promote expansion of CD34+ HSCs and/or differentiation into progenitor cells (e.g., megakaryocytic progenitors). The present description also relates to in vitro expanded cell populations of HSCs and/or progenitors, as well as uses thereof in therapy (e.g., transplantation).
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: November 10, 2020
    Assignee: HEMA-QUEBEC
    Inventors: Josée Laganière, Nellie Dumont
  • METHODS FOR CULTURING AND/OR DIFFERENTIATING HEMATOPOIETIC STEM CELLS INTO PROGENITORS AND USES THEREOF
    Publication number: 20180147239
    Abstract: The present description relates to in vitro methods for culturing hematopoietic stem cells (HSCs) under mild hyperthermia conditions (e.g., between 38° C. and 40° C.) in the presence of a pyrimidoindole derivative agonist of hematopoietic stem cell expansion. The combined use of mild hyperthermia and the pyrimidoindole derivative act synergistically to promote expansion of CD34+ HSCs and/or differentiation into progenitor cells (e.g., megakaryocytic progenitors). The present description also relates to in vitro expanded cell populations of HSCs and/or progenitors, as well as uses thereof in therapy (e.g., transplantation).
    Type: Application
    Filed: June 3, 2016
    Publication date: May 31, 2018
    Inventors: Josée Laganière, Nellie Dumont
  • Methods and compositions for gene correction
    Patent number: 9631187
    Abstract: Disclosed herein are methods and compositions for correction and/or mutation of genes associated with Parkinson's Disease as well as clones and animals derived therefrom.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: April 25, 2017
    Assignees: Sangamo BioSciences, Inc., Whitehead Institute for Biomedical Research
    Inventors: Rudolf Jaenisch, Josee Laganiere, Frank Soldner, Lei Zhang
  • Methods and compositions for gene correction
    Patent number: 9267123
    Abstract: Disclosed herein are methods and compositions for correction and/or mutation of genes associated with Parkinson's Disease as well as clones and animals derived therefrom.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: February 23, 2016
    Assignees: Sangamo BioSciences, Inc., Whitehead Institute for Biomedical Research
    Inventors: Rudolf Jaenisch, Josee Laganiere, Frank Soldner, Lei Zhang
  • METHODS AND COMPOSITIONS FOR GENE CORRECTION
    Publication number: 20160046683
    Abstract: Disclosed herein are methods and compositions for correction and/or mutation of genes associated with Parkinson's Disease as well as clones and animals derived therefrom.
    Type: Application
    Filed: October 29, 2015
    Publication date: February 18, 2016
    Inventors: Rudolf Jaenisch, Josee Laganiere, Frank Soldner, Lei Zhang
  • SCREENING ASSAYS FOR THERAPEUTICS FOR PARKINSON'S DISEASE
    Publication number: 20160010154
    Abstract: Disclosed herein are in vitro and in vivo methods for screening for compounds that treat diseases and conditions that are related to oxidative stress such as Parkinson's disease
    Type: Application
    Filed: December 2, 2013
    Publication date: January 14, 2016
    Inventors: Josee LAGANIERE, Birgitt SCHÜLE
  • Methods and compositions for modification of the HPRT locus
    Patent number: 9222105
    Abstract: Nucleases and methods of using these nucleases for modification of an HPRT locus and for increasing the frequency of gene modification at a targeted locus and clones and for generating animals.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: December 29, 2015
    Assignees: Sangamo BioSciences, Inc., The Regents of the University of California
    Inventors: Gregory J. Cost, Michael C. Holmes, Noriyuki Kasahara, Josee Laganiere, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Fyodor Urnov, Lei Zhang
  • Methods and compositions for modification of the locus
    Patent number: 8895264
    Abstract: Nucleases and methods of using these nucleases for modification of an HPRT locus and for increasing the frequency of gene modification at a targeted locus and clones and for generating animals.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: November 25, 2014
    Assignees: Sangamo BioSciences, Inc., The Regents of the University of California
    Inventors: Gregory J. Cost, Michael C. Holmes, Noriyuki Kasahara, Josee Laganiere, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Fyodor Urnov, Lei Zhang
  • Methods and compositions for treating neuropathies
    Patent number: 8551945
    Abstract: Disclosed herein are methods and compositions for treating neuropathies by modulating endogenous NT-3 of GDNF gene expression.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: October 8, 2013
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Carolyn Dent, Josee Laganiere, Xiangdong Meng, David Paschon, Siyuan Tan, Lei Zhang, Steve H. Zhang
  • METHODS AND COMPOSITIONS FOR INCREASING PRODUCTION OF INDUCED PLURIPOTENT STEM CELLS (IPSCS)
    Publication number: 20120252122
    Abstract: Disclosed herein are methods and compositions for increasing yield of induced pluripotent stem cells (iPSCs).
    Type: Application
    Filed: December 15, 2011
    Publication date: October 4, 2012
    Inventor: Josee LAGANIERE
  • ZINC FINGER NUCLEASE MODIFICATION OF LEUCINE RICH REPEAT KINASE 2 (LRRK2) MUTANT FIBROBLASTS AND IPSCS
    Publication number: 20120214241
    Abstract: Disclosed herein are methods and compositions for alteration of an LRRK2 gene in a fibroblast or iPSC.
    Type: Application
    Filed: December 15, 2011
    Publication date: August 23, 2012
    Inventors: Josee LAGANIERE, J. William Langston, Birgitt Schüle, H. Steve Zhang
  • METHODS AND COMPOSITIONS FOR GENE CORRECTION
    Publication number: 20120192301
    Abstract: Disclosed herein are methods and compositions for correction and/or mutation of genes associated with Parkinson's Disease as well as clones and animals derived therefrom.
    Type: Application
    Filed: December 15, 2011
    Publication date: July 26, 2012
    Inventors: Rudolf Jaenisch, Josee Laganiere, Frank Soldner, Lei Zhang
  • Methods and compositions for treating neuropathies
    Publication number: 20110082078
    Abstract: Disclosed herein are methods and compositions for treating neuropathies by modulating endogenous NT-3 of GDNF gene expression.
    Type: Application
    Filed: February 4, 2010
    Publication date: April 7, 2011
    Inventors: Carolyn Dent, Josee Laganiere, Xiangdong Meng, David Paschon, Siyuan Tan, Lei Zhang, Steve H. Zhang