Patents by Inventor Josef Holub

Josef Holub has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carbonic anhydrase inhibitors and method of their production
    Patent number: 9290529
    Abstract: Derivatives of boron cluster compounds of general formula I and their pharmaceutically acceptable salts and solvates, and their specific inhibition effect on the enzyme carbonic anhydrase IX, a protein overexpressed in cancer tissues. Methods of synthesis and the use of the novel derivatives. These inhibitors of human carbonic anhydrase IX can be used as active compounds of pharmaceuticals for diagnostics and/or therapy of cancer diseases.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: March 22, 2016
    Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CESKE REPUBLIKY, V.V.I., USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY, V.V.I., USTAV ANORGANICKE CHEMIE AKADEMIE VED CESKE REPUBLIKY, V.V.I., UNIVERZITA PALACKEHO V OLOMOUCI
    Inventors: Jiri Brynda, Petr Cigler, Bohumir Gruner, Pavlina Maloy Rezacova, Pavel Mader, Vaclav Sicha, Mario Bakardjiev, Josef Holub, Petr Dzubak, Marian Hajduch
  • CARBONIC ANHYDRASE INHIBITORS AND METHOD OF THEIR PRODUCTION
    Publication number: 20140303390
    Abstract: Derivatives of boron cluster compounds of general formula I and their pharmaceutically acceptable salts and solvates, and their specific inhibition effect on the enzyme carbonic anhydrase IX, a protein overexpressed in cancer tissues. Methods of synthesis and the use of the novel derivatives. These inhibitors of human carbonic anhydrase IX can be used as active compounds of pharmaceuticals for diagnostics and/or therapy of cancer diseases.
    Type: Application
    Filed: October 24, 2012
    Publication date: October 9, 2014
    Applicants: UNIVERZITA PALACKEHO V OLOMOUCI, USTAV ORGANICKE CHEMIE A BIOCHEME AKADEMIE VED CESKE REPUBLIKY, v.v.i., USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY, v.v.i
    Inventors: Jiri Brynda, Petr Cigler, Bohumir Gruner, Pavlina Maloy Rezacova, Pavel Mader, Vaclav Sicha, Mario Bakardjiev, Josef Holub, Petr Dzubak, Marian Hajduch
  • Arrangement for guiding a weft thread end under tension toward a fabric fell in travelling-wave looms
    Patent number: 4194537
    Abstract: An arrangement for tensioning the end of an inserted weft for beat-up of the weft into a fell by a rotary reed is described. An elongated weft-gripping mechanism is movable forwardly opposite the direction of movement of the portion of the reed which engages the weft being inserted along an axis oblique to the rotary reed into a frontmost position where it engages a weft carried by each of a succession of weft inserters as soon as the inserter has moved past the end of the reed into which the weft has just been inserted. A pair of jaws on the outer end of the gripping mechanism then close to grip the engaged weft and to move it rearwardly into a securing position between a thrust plate and a toothed, weft-guiding disc coaxial with the rotary reed. After the weft is secured, the jaws of the gripping means open and the gripping mechanism is moved forwardly again to grip the next weft.
    Type: Grant
    Filed: October 4, 1976
    Date of Patent: March 25, 1980
    Assignee: Vyzkumny ustav bavlnarsky
    Inventors: Miloslav Hodr, Josef Holub, Jiri Stefek
  • Apparatus for stabilizing the fabric within the weft beat-up area in wave weaving looms
    Patent number: 3967655
    Abstract: A method of and apparatus for stabilizing the fabric within the weft beat-up area in multiple-shed weaving machines or wave weaving loom wherein the beat-up is effected by means of a rotary reed. Immediately after the weft has been beaten-up, the fabric passes through a stabilization slot, and after having passed therethrough, it changes the direction of its movement beyond the level of the weaving plane.
    Type: Grant
    Filed: June 1, 1973
    Date of Patent: July 6, 1976
    Assignee: Vyzkumny Ustav Bavlnarsky
    Inventors: Dalibor Sejbal, Josef Holub, Zbynek Miks, Vitezslav Vasek