Abstract: A method for pressing a workpiece with a predetermined pressing force uses a forming tool coupled with an electric motor via a spindle drive that converts the rotational movement of the electric motor drive shaft to a translational movement of the forming tool. The method includes: accelerating the electric motor in a first rotational direction to a predetermined maximal speed of rotation; operating the electric motor at the maximal speed until the drive shaft has completed a predetermined number of revolutions; reducing the speed of rotation of the electric motor to a predetermined reduced speed of rotation; operating the electric motor at the reduced speed until a pressing force increase exceeding a predetermined threshold value is detected by a measuring unit that follows the electric motor; forming the workpiece with constant detection of the pressing force by the measuring unit until the predetermined pressing force has been reached.

Abstract: The invention relates to a method for driving a screw (4) with a predetermined tightening torque by means of a screwdriving tool (3), which is coupled with an electric motor (2), which is activated by a regulation (8). The method comprises the following method steps: acceleration of the electric motor (2) in screwing-in direction (15) to a predetermined maximum rotational speed, operation of the electric motor (2) at maximum rotational speed until a drive shaft (11) of the electric motor (2) has completed a specified number of spindle revolutions, reduction of the rotational speed of the electric motor (2) to a predetermined reduced rotational speed; operation of the electric motor (2) at reduced speed until a torque increase that exceeds a predetermined threshold value is detected by a measuring unit (14) connected downstream from the electric motor (2); subsequent turning of the screw (4) or nut until the predetermined tightening torque is reached.

Abstract: A method for pressing a workpiece with a predetermined pressing force uses a forming tool coupled with an electric motor via a spindle drive that converts the rotational movement of the electric motor drive shaft to a translational movement of the forming tool. The method includes: accelerating the electric motor in a first rotational direction to a predetermined maximal speed of rotation; operating the electric motor at the maximal speed until the drive shaft has completed a predetermined number of revolutions; reducing the speed of rotation of the electric motor to a predetermined reduced speed of rotation; operating the electric motor at the reduced speed until a pressing force increase exceeding a predetermined threshold value is detected by a measuring unit that follows the electric motor; forming the workpiece with constant detection of the pressing force by the measuring unit until the predetermined pressing force has been reached.

Abstract: The invention relates to the use of mGluR5 antagonists for treating pruritic conditions.

Abstract: Lactones of Formula (I) which are pharmaceutically active in diseases associated with inflammation.

Abstract: Pharmaceutically active diazepanes, e.g. useful for treating disorders or diseases mediated by LFA-1/ICAM-1, LFA-1/ICAM-2, LFA-1/ICAM-3 or LFA-1/JAM-1 interactions.

Abstract: Synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and a calciferol or tacalcitol are provided, which are useful in particular in the treatment of dermatological diseases such as atopic dermatitis, acen and psoriasis or of inflammatory bowel disease (IBD).

Abstract: Additive or synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and a retinoid, such as etretinate, isotretinoin or tazarotene, optionally with a further pharmaceutically active agent, especially an antibacterial, are provided, which are useful in particular in the treatment of dermatological diseases such as eczema, atopic dermatitis, acne, psoriasis, skin aging, sun damage, post-peel erythema and stretch marks.

Abstract: The compounds of formula I, have been found to have excellent topical activity. They are thus indicated for use in the topical treatment of inflammatory and hyperpoliferative skin diseases and of cutaneous manifestations of immunologically-induced illnesses, such as psoriasis.