Abstract: Devices and methods are provided for creating lesions in endocardial tissues surrounding a vessel opening to thereby isolate focal arrhythmia substrates, including an invasive catheter assembly comprising an elongate body having a longitudinal axis and first and second lumens, a first catheter having a distally mounted expandable anchor body disposed in the first lumen, and a second catheter having a distally mounted electrode disposed in the second lumen, the elongate body having a first distal opening accessing the first lumen through which the first catheter may be extended axially relative to the longitudinal axis of the elongate body and a second distal opening accessing the second lumen through which the second catheter may be extended at an angle relative to the longitudinal axis of the elongate body.

Abstract: A method for manufacturing a catheter assembly including a handle, a guide tube having a proximal end engaged with the handle, and a distal end assembly engaged with a distal end of the guide tube. The method includes applying an active electrode element on the distal end assembly by a process selected from the group consisting of electroplating, vapor deposition, IBAD and pad printing, and applying a regenerated cellulose coating over the distal end assembly. The regenerated cellulose coating is applied by applying a viscous liquid coating to the catheter distal end assembly, regenerating the viscous coating, and then curing the regenerated coating. The cured coating is preferably hydrated.

Abstract: A probe that facilitates the creation of circumferential lesions in body tissue. The probe includes a elongate body and a loop structure that supports electrodes or other operative elements against the body tissue.

Abstract: A method of deploying a helical structure having at least one operative element within a bodily structure defining an orifice includes the steps of inserting at least a portion of the helical structure through the orifice in an uncoiled state and returning the helical structure to a coiled state while at least a portion of the helical structure is within the bodily structure such that the coiled helical structure engages the orifice.

Abstract: A probe that facilitates the creation of circumferential lesions in body tissue. The probe includes a probe body and a helical or loop structure that supports electrodes or other operative elements against the body tissue.

Abstract: A loop structure for supporting operative elements in contact with bodily tissue including an elongate body. The elongate body may include an area with a preset curvature and/or a hinge area.

Abstract: A probe that facilitates the creation of lesions in bodily tissue. The probe includes a relatively short shaft and an inflatable therapeutic element.

Abstract: A loop structure for supporting operative elements in contact with bodily tissue including an elongate body. The elongate body may include an area with a preset curvature and/or a hinge area.

Abstract: A surgical method and apparatus for positioning a diagnostic or therapeutic element within the body. The apparatus may be catheter-based or a probe including a relatively short shaft.

Abstract: A deflectable catheter for ablating tissue in the heart of a patient comprising: an axially elongated catheter shaft sized and constructed to be advanced through the vasculature of a patient into the patient's heart; a deflection wire; and an ablation electrode having first and second opposed electrically conductive surfaces exposable for contact with a selected area of tissue within the patient's heart and movable with respect to each other to apply gripping force to the contacted area of heart tissue for stabilizing the position of the electrically conductive surfaces of the ablation electrode relative to the selected area of heart tissue.

Abstract: A catheter assembly having a sheath, which includes a side wall enclosing an interior bore, and a distal region. The assembly also has a bendable catheter tube, which is carried for sliding movement in the interior bore. A pull wire also runs through the interior bore of the sheath, preferably within a lumen. The catheter tube has a distal portion with a coupling which joins the distal portion of the catheter tube and the distal portion of the pull wire. Relative movement of the pull wire and the sheath causes bending of the catheter tube outwardly through the opening, in response to sliding movement of the catheter tube within the interior bore toward the distal region of the sheath.

Abstract: A catheter including a distal end assembly having an external surface coating. Where the distal end assembly includes electrodes or other electrical components, the coating is preferably electrically conductive. Such an electrically conductive coating is formed from a material comprising regenerated cellulose, although other materials such as a hydrogel or a plastic having an electrically conductive component are utilizable. Where the distal end assembly includes optical or ultrasonic components, the regenerated cellulose coating is suitable. The robustness of the surface coating permits the manufacture and utilization of electrode configurations that are formed on a non-conductive base member by processes such as pad printing, vapor deposition, ion beam assisted deposition, electroplating and other printed circuit manufacturing processes.

Abstract: A deflectable biopsy catheter for obtaining a tissue sample from a body cavity of a patient comprising: an axially elongated catheter shaft having proximal and distal portions respectively terminating at proximal and distal ends, the catheter shaft being sized and constructed to be advanced into a body cavity of a patient; a deflection wire coupled to the distal portion of the catheter shaft and extending within the catheter to the proximal end thereof; and a pair of biopsy jaws coupled to the distal end of the catheter shaft and having first and second opposed free cutting surfaces exposable for contact with a selected area of tissue within the patient's body cavity and movable with respect to each other to cut a tissue sample from the selected area of tissue. Schemes for obtaining samples from body cavities (e.g., the gastrointestinal tract, the heart, the intestines, the uterus, the muscles, the bile duct, and the esophagus) are disclosed.

Abstract: A catheter assembly having a sheath, which includes a side wall enclosing an interior bore, and a distal region. The assembly also has a bendable catheter tube, which is carried for sliding movement in the interior bore. A pull wire also runs through the interior bore of the sheath, preferably within a lumen. The catheter tube has a distal portion with a coupling which joins the distal portion of the catheter tube and the distal portion of the pull wire. Relative movement of the pull wire and the sheath causes bending of the catheter tube outwardly through the opening, in response to sliding movement of the catheter tube within the interior bore toward the distal region of the sheath.

Abstract: A bidirectional catheter with a deflectable tip at a distal end includes a handle at a proximal end and a tubular member extending between the tip and the handle. The handle includes a first piston member slidably mounted in a handle base with proximal ends of steering wires secured in the handle. The steering wires extend through the tubular member with respective distal ends thereof secured to circumferentially spaced portions of the distal end tip. Axial displacement of the piston member in a second direction conversely urges deflection of the distal end tip in a second direction by tensioning the other wire relative to the first wire. The piston member can include another piston member slidable in the first piston member with the proximal ends of the steering wires secured in the first mentioned piston member and the handle member, respectively, and with the other piston member supporting a proximal end of the tubular member.

Abstract: For achieving, e.g., an improved electrophysiology catheter for examination of the heart, or a catheter accessing the brain, the invention, in one aspect, features an elongated wound wire coil extending through the hollow catheter body of a steerable catheter. The coil is constructed and arranged to enable the catheter body to withstand reactive compressive load without distortion during application of tension on the pull wire and to transmit torque from the proximal to the distal tip portion of the catheter to enhance fidelity of rotational positioning of the distal tip in response to rotational orientation of the proximal portion of the catheter. The coil is shown in frictional torque-transmitting relationship with the interior of the hollow shaft substantially along the common length of the catheter body when the catheter is bent. Steerable catheters with augmented throw for one-handed operation and important improvements in construction features are also shown.

Abstract: A deflectable biopsy catheter for obtaining a tissue sample from a body cavity of a patient comprising: an axially elongated catheter shaft having proximal and distal portions respectively terminating at proximal and distal ends, the catheter shaft being sized and constructed to be advanced into a body cavity of a patient; a deflection wire coupled to the distal portion of the catheter shaft and extending within the catheter to the proximal end thereof; and a pair of biopsy jaws coupled to the distal end of the catheter shaft and having first and second opposed free cutting surfaces exposable for contact with a selected area of tissue within the patient's body cavity and movable with respect to each other to cut a tissue sample from the selected area of tissue. Schemes for obtaining samples from body cavities (e.g., the gastrointestinal tract, the heart, the intestines, the uterus, the muscles, the bile duct, and the esophagus) are disclosed.

Abstract: A deflectable biopsy catheter for obtaining a tissue sample from a body cavity of a patient comprising: an axially elongated catheter shaft having proximal and distal portions respectively terminating at proximal and distal ends, the catheter shaft being sized and constructed to be advanced into a body cavity of a patient; a deflection wire coupled to the distal portion of the catheter shaft and extending within the catheter to the proximal end thereof; and a pair of biopsy jaws coupled to the distal end of the catheter shaft and having first and second opposed free cutting surfaces exposable for contact with a selected area of tissue within the patient's body cavity and movable with respect to each other to cut a tissue sample from the selected area of tissue. Schemes for obtaining samples from body cavities (e.g., the gastrointestinal tract, the heart, the intestines, the uterus, the muscles, the bile duct, and the esophagus) are disclosed.

Abstract: A bidirectional catheter with a deflectable tip at a distal end includes a handle at a proximal end and a tubular member extending between the tip and the handle. The handle includes a first piston member slidably mounted in a handle base with proximal ends of steering wires secured in the handle. The steering wires extend through the tubular member with respective distal ends thereof secured to circumferentially spaced portions of the distal end tip. Axial displacement of the piston member in a second direction conversely urges deflection of the distal end tip in a second direction by tensioning the other wire relative to the first wire. The piston member can include another piston member slidable in the first piston member with the proximal ends of the steering wires secured in the first mentioned piston member and the handle member, respectively, and with the other piston member supporting a proximal end of the tubular member.

Abstract: For achieving, e.g., an improved electrophysiology catheter for examination of the heart, or a catheter accessing the brain, the invention, in one aspect, features an elongated wound wire coil extending through the hollow catheter body of a steerable catheter, the coil constructed and arranged to enable the catheter body to withstand reactive compressive load without distortion during application of tension on the pull wire and to transmit torque from the proximal to the distal tip portion of the catheter to enhance fidelity of rotational positioning of the distal tip in response to rotational orientation of the proximal portion of the catheter. The coil is shown in frictional torque-transmitting relationship with the interior of the hollow shaft substantially along the common length of the catheter body when the catheter is bent. Steerable catheters with augmented throw for one-handed operation and important improvements in construction features are also shown.