Patents by Inventor Joseph A. Ippolito

Joseph A. Ippolito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190211018
    Abstract: The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals. In some embodiments, the present disclosure provides a compound of Formula (I): or a tautomer thereof or a pharmaceutically acceptable salt of the compound or tautomer.
    Type: Application
    Filed: May 5, 2017
    Publication date: July 11, 2019
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Zoltan F. Kanyo, Joseph A. Ippolito
  • Publication number: 20190194205
    Abstract: The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals. In some embodiments, the present disclosure provides a compound of Formula (I) or a tautomer thereof or a pharmaceutically acceptable salt of the compound or tautomer.
    Type: Application
    Filed: May 5, 2017
    Publication date: June 27, 2019
    Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Zoltan F. Kanyo, Joseph A. Ippolito
  • Publication number: 20180221677
    Abstract: An extra-cardiovascular implantable cardioverter defibrillator (ICD) having a high voltage therapy module is configured to control a high voltage charging circuit to charge a capacitor to a pacing voltage amplitude to deliver charge balanced pacing pulses. The capacitor is chargeable to a shock voltage amplitude that is greater than the pacing voltage amplitude. The ICD is configured to enable switching circuitry of the high voltage therapy module to discharge the capacitor to deliver a first pulse having a first polarity and a leading voltage amplitude corresponding to the pacing voltage amplitude for pacing the patient's heart via a pacing electrode vector selected from extra-cardiovascular electrodes. The high voltage therapy module delivers a second pulse after the first pulse. The second pulse has a second polarity opposite the first polarity and balances the electrical charge delivered during the first pulse.
    Type: Application
    Filed: February 6, 2017
    Publication date: August 9, 2018
    Inventors: Yanina GRINBERG, Paul D. BAKER, Lonny V. CABELKA, Craig W. DORMA, Timothy A. EBELING, Michael W. HEINKS, James VANDER HEYDEN, Joseph IPPOLITO, Joel R. LAUER, Robert W. SAWCHUK, Brian W. SCHOUSEK
  • Publication number: 20180066007
    Abstract: The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
    Type: Application
    Filed: April 21, 2017
    Publication date: March 8, 2018
    Inventors: Jay J. Farmer, Ashoke Bhattacharjee, Yi Chen, Joel A. Goldberg, Joseph A. Ippolito, Zoltan F. Kanyo, Rongliang Lou, Adegboyega K. Oyelere, Edward C. Sherer, Joyce A. Sutcliffe, Deping Wang, Yusheng Wu, Yanming Du
  • Publication number: 20150258092
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Application
    Filed: November 25, 2014
    Publication date: September 17, 2015
    Applicants: YALE UNIVERSITY, MELINTA THERAPEUTICS, INC.
    Inventors: Thomas Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
  • Publication number: 20150158901
    Abstract: The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
    Type: Application
    Filed: July 9, 2014
    Publication date: June 11, 2015
    Inventors: Jay J. Farmer, Ashoke Bhattacharjee, Yi Chen, Joel A. Goldberg, Joseph A. Ippolito, Zoltan F. Kanyo, Rongliang Lou, Adegboyega K. Oyelere, Edward C. Sherer, Joyce A. Sutcliffe, Deping Wang, Yusheng Wu, Yanming Du
  • Patent number: 8912150
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: December 16, 2014
    Assignees: Melinta Therapeutics, Inc., Yale University
    Inventors: Thomas A. Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
  • Patent number: 8841263
    Abstract: The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: September 23, 2014
    Assignee: Melinta Therapeutics, Inc.
    Inventors: Jay J. Farmer, Ashoke Bhattacharjee, Yi Chen, Joel A. Goldberg, Joseph A. Ippolito, Zoltan F. Kanyo, Rongliang Lou, Adegboyega K. Oyelere, Edward C. Sherer, Joyce A. Sutcliffe, Deping Wang, Yusheng Wu, Yanming Du
  • Publication number: 20140066623
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Application
    Filed: June 21, 2013
    Publication date: March 6, 2014
    Inventors: THOMAS A. STEITZ, PETER B. MOORE, JOYCE A. SUTCLIFFE, ADEGBOYEGA K. OYELERE, JOSEPH A. IPPOLITO
  • Patent number: 8470990
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: June 25, 2013
    Assignees: Rib-X Pharmaceuticals, Inc., Yale University
    Inventors: Thomas A. Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
  • Publication number: 20120252747
    Abstract: The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
    Type: Application
    Filed: June 18, 2012
    Publication date: October 4, 2012
    Inventors: Jay J. Farmer, Ashoke Bhattacharjee, Yi Chen, Joel A. Goldberg, Joseph A. Ippolito, Zoltan F. Kanyo, Rongliang Lou, Adegboyega K. Oyelere, Edward C. Sherer, Joyce A. Sutcliffe, Deping Wang, Yusheng Wu, Yanming Du
  • Patent number: 8202843
    Abstract: The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: June 19, 2012
    Assignee: Rib-X Pharmaceuticals, Inc.
    Inventors: Jay J. Farmer, Ashoke Bhattacharjee, Yi Chen, Joel A. Goldberg, Joseph A. Ippolito, Zoltan F. Kanyo, Rongliang Lou, Adegboyega K. Oyelere, Edward C. Sherer, Joyce A. Sutcliffe, Deping Wang, Yusheng Wu, Yanming Du
  • Publication number: 20100312525
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Application
    Filed: February 10, 2010
    Publication date: December 9, 2010
    Inventors: Thomas A. Steitz, Peter B. Moore, Nenad Ban, Poul Nissen, Jeffrey Hansen, Joseph A. Ippolito
  • Publication number: 20100204253
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Application
    Filed: December 23, 2009
    Publication date: August 12, 2010
    Applicants: Yale University, Rib-X Pharmaceuticals, Inc.
    Inventors: Thomas Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
  • Patent number: 7666849
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: February 23, 2010
    Assignees: Rib-X Pharmaceuticals, Inc., Yale University
    Inventors: Thomas A. Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
  • Publication number: 20090298582
    Abstract: A method for securing, distributing, and updating a browser-based game includes encrypting a compiled browser-based computer game and wrapping the encrypted compiled browser-based computer game within a browser-based game loader. The browser-based game loader is executable by a web browser to decrypt the encrypted browser-based computer game and, in some embodiments, update the browser-based computer game to a newer version prior to execution.
    Type: Application
    Filed: May 30, 2008
    Publication date: December 3, 2009
    Inventors: Matthew Robert Dempsky, Robert Joseph Ippolito
  • Publication number: 20080119419
    Abstract: The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and/or prokinetic agents.
    Type: Application
    Filed: December 21, 2007
    Publication date: May 22, 2008
    Inventors: Deping Wang, Joyce Sutcliffe, Adegboyega Oyelere, Timothy McConnell, Joseph Ippolito, John Abelson, Dane Springer, Joseph Salvino, Joel Goldberg, Rongliang Lou, Jay Farmer, Erin Duffy, Ashoke Bhattacharjee
  • Patent number: 7335753
    Abstract: The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and/or prokinetic agents.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: February 26, 2008
    Assignee: Rib-X Pharmaceuticals, Inc.
    Inventors: Deping Wang, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Timothy S. McConnell, Joseph A. Ippolito, John N. Abelson, Dane M. Springer, Joseph M. Salvino, Rongliang Lou, Joel A. Goldberg, Jay J. Farmer, Erin M. Duffy, Ashoke Bhattacharjee
  • Publication number: 20080045585
    Abstract: The present invention provides macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
    Type: Application
    Filed: February 25, 2005
    Publication date: February 21, 2008
    Inventors: Jay Farmer, Ashoke Bhattacharjee, Yi Chen, Joel Goldberg, Joseph Ippolito, Zoltan Kanyo, Rongliang Lou, Adegboyega Oyelere, Edward Sherer, Joyce Sutcliffe, Deping Wang, Yusheng Wu, Yanming Du
  • Publication number: 20060264385
    Abstract: The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and/or prokinetic agents.
    Type: Application
    Filed: February 21, 2006
    Publication date: November 23, 2006
    Inventors: Deping Wang, Joyce Sutcliffe, Adegboyega Oyelere, Timothy McConnell, Joseph Ippolito, John Abelson, Dane Springer, Joseph Salvino, Rongliang Lou, Joel Goldberg, Jay Farmer, Erin Duffy, Ashoke Bhattacharjee