Abstract: This invention is in the area of improved compounds, compositions and methods of transiently protecting healthy cells, and in particular hematopoietic stem and progenitor cells (HSPC) as well as renal cells, from damage associated with DNA damaging chemotherapeutic agents. In one aspect, improved protection of healthy cells is disclosed using disclosed compounds that act as highly selective and short, transiently-acting cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors when administered to subjects undergoing DNA damaging chemotherapeutic regimens for the treatment of proliferative disorders.

Abstract: In a method for applying penalties or incentives to a driver of a rented vehicle, an indication that the driver has agreed to terms for renting the vehicle from the vehicle owner is received, with the terms including the potential application of penalties or incentives to the driver based on driving behavior. Telematics data, indicative of operation of the rented vehicle by the driver during a period of time, is received. By analyzing the telematics data, one or more driving behaviors of the driver during the time period is/are identified. For each driving behavior, a corresponding state of an environment of the rented vehicle when the driving behavior occurred is determined. One or more penalties or incentives are caused to be applied to the driver, based on the driving behavior(s) and the corresponding state(s) of the environment of the rented vehicle.

Abstract: Methods and apparatus to communicate via a weld cable are disclosed. An example welding accessory includes a first port to receive input power via a first weld cable, a power converter to convert the input power to output power, a second port to output the input power via a second weld cable, and one or more output switches to selectively divert the input power from the power converter to the second port.

Abstract: This invention is in the area of improved compounds for and methods of treating selected RB-positive cancers and other Rb-positive abnormal cellular proliferative disorders while minimizing the deleterious effects on healthy cells, for example healthy Hematopoietic Stem Cells and Progenitor Cells (HSPCs), associated with current treatment modalities. In one aspect, improved treatment of select RB-positive cancers is disclosed using specific compounds disclosed herein. In certain embodiments, the compounds described herein act as highly selective and, in certain embodiments, short, transiently-acting cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors when administered to subjects.

Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as cancer and tumors, as well as viral infections such as HIV.

Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as cancer and tumors, as well as viral infections such as HIV.

Abstract: A single-package air conditioner unit may include a housing, an outdoor heat exchanger, an indoor heat exchanger, an indoor air conduit, and an internal shield. The indoor fan may be held within a fan cowl defining a cowl outlet. The indoor air conduit may be mounted to the fan cowl and extend upward from the cowl outlet to an indoor outlet defined through the housing to guide air from the indoor fan. The indoor air conduit and the fan cowl may separate at least a portion of the indoor portion from the outdoor portion. The internal shield may be disposed within the outdoor portion rearward from the indoor air conduit and the fan cowl. The internal shield may extend between an upper edge and a lower edge. The lower edge may be disposed between the downward bottom end and the cowl outlet relative to a vertical direction.

Abstract: Described herein are tricyclic PARP1 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of cancer.

Abstract: An apparatus for providing material feedstock into a plasma of a plasma torch includes a material feeding device having an input end and an output end. The output end of the material feeding device extends at least partially around the periphery of a plasma generated near the output end of the plasma torch. The material feeding device is oriented at an angle with respect to a central axis of the plasma torch.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for training a machine learning model using a deterministic data pipeline. One of the methods may include receiving a first request to generate a deterministic training dataset: transforming raw training examples obtained from the raw data source into pre-processed training examples; assigning a unique index to each pre-processed training example; and caching the pre-processed training examples into the cache directory specified in the received first request; receiving a second request to use the deterministic training dataset to train a machine learning model, the second request specifying a start index; and in response to receiving the second request: reading, from the cache directory, the pre-processed training examples that have indices beginning from the start index; and providing the read training examples in an order of the assigned indices for use in training the machine learning model.

Abstract: A battery housing assembly for housing battery components of an electric vehicle includes a battery tray, a lid, and a sealant. The battery tray includes a channel located outwardly relative to the battery components. The lid is secured to the battery tray and includes an end portion disposed within the channel. The lid further includes at least one alignment feature configured to align the lid and the battery tray. The sealant is disposed within a portion of the channel of the battery tray and is configured to secure the battery tray and the lid to each other. The sealant is further configured to seal an internal cavity of the battery housing assembly.

Abstract: A method of facilitating first mile/ last mile transfer of a vehicle includes: analyzing a first route and a second route using a trained machine learning model to determine, respectively, a first cost of the first route and a second cost of the second route to a user; wherein the trained machine learning model is trained using at least one of a detour in time, a delay in miles, a time of day, a traffic congestion factor, or profile information about a ride share passenger; causing a message including the first cost and the second cost to be displayed to the user via an electronic device of the user; and receiving an indication of whether the user selects the first route or the second route.

Abstract: Described herein are tricyclic PARP1 inhibitors and pharmaceutical compositions comprising said inhibitors.

Abstract: The present invention relates to novel anti-PD1 and anti-LAG3 antibody molecules. The invention also relates to nucleic acids encoding such antibody molecules; to methods for preparing such antibody molecules; to host cells expressing or capable of expressing such antibody molecules; to compositions comprising such antibody molecules; and to uses of such antibody molecules or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Abstract: An adaptive mapping (AM) computing device having at least one processor in communication with at least one memory device is provided. The AM computing device may be configured to retrieve a plurality of tasks associated with a user, and retrieve geographic mapping data. The AM computing device may also generate a route model based upon the retrieved plurality of tasks and the retrieved geographic mapping data. The AM computing device may execute the route model to determine an optimal route, and transmit, to the user, an optimized travel plan based upon the optimal route.

Abstract: An air conditioner unit includes a cabinet including a base pan that defines at least one alignment feature and a compressor mounted to the base pan using mechanical fasteners that pass through mounting feet and into mounting bosses defined on the base pan. A damper is positioned between the compressor and the base pan and includes a lower pad seated on the base pan, an upper pad extending from the lower pad along the vertical direction and contacting a bottom surface of the compressor, and at least one stopping feature defined on the lower pad or the upper pad, the at least one stopping feature engaging the at least one alignment feature to prevent rotation of the damper.

Abstract: The following relates generally to providing virtual reality (VR) alerts to a driver of an autonomous vehicle. For example, a vehicle may be driving autonomously while the driver is watching a VR movie (e.g., on a pair of VR goggles); the driver may then receive a VR alert recommending that the driver take control of the vehicle (e.g., switch the vehicle from autonomous to manual mode). The following also relates to generating a VR feed for presenting real-time road conditions so that a user may preview a road segment. The following also relates to generating a VR feed corresponding to an event (e.g., a vehicle collision, a crime, a weather event, and/or a natural disaster).

Abstract: A vehicle battery tray includes a floor assembly that has elongated tray sections that attach together at lateral edge portions of adjacent tray sections to form a floor structure that supports vehicle batteries contained in the vehicle battery tray. The elongated tray sections each have a substantially consistent cross-sectional shape that extends longitudinally along a length of the respective tray section. A first tray section includes a first attachment feature at the lateral edge portion thereof and a second tray section includes a second attachment feature at the lateral edge portion thereof that corresponds with the first attachment feature. The first and second attachment features engage together at a longitudinal seam between the lateral edge portions of the first and second tray sections, such as to align upper surfaces of the first and second tray sections.

Abstract: Systems and methods for preventing rotation of an ESP motor when the motor is not powered on, thereby preventing the motor from acting as a generator when fluid flowing through the pump section of the ESP applies a torque to the motor. In one embodiment, an ESP has a motor section, a pump section. The ESP may include a directional coupling that allows unidirectional rotation between the motor shaft and a pump shaft of the pump section, and a directional lock that allows unidirectional rotation between the motor shaft and a housing of the motor section. The directional coupling and directional lock allow the pump shaft to freewheel in the forward direction without causing the motor shaft to rotate, and prevent the pump shaft and motor from rotating in the reverse direction.

Abstract: Techniques of contextual data analysis in distributed computing systems are disclosed herein. In one example, upon receiving operational data and attribute data representing attributes of multiple entities in the distributed computing system, a decision tree is generated based on the received operational and attribute data via machine learning. The decision tree has a root and multiple branches each representing a set of the attributes in the attribute data and a corresponding probability value representing a likelihood that one of the multiple components with the set of the attributes would be associated with an event in the distributed computing system. The multiple branches can then be parsed to identify a common subset of the attributes of the multiple components as most closely related to an occurrence of the event in the distributed computing system.