Abstract: The ?2-adrenergic receptor (?2AR) is a primary target in the treatment of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). Since ?-agonist treatment of airway disease can have severe side effects, compounds that attenuate the side effects of ?-agonists have been identified via their ability to inhibit ?2AR interaction with ?-arrestins. These compounds are specific for the ?2AR and effectively protect against the desensitization observed with ?-agonist treatment in model cells and airway tissue. The present disclosure provides compounds and methods for treating airway disease, such as but not limited to COPD and/or asthma.

Abstract: Various systems and methods are provided for a biased cathode assembly of an X-ray tube with improved thermal management and a method of manufacturing same. In one example, a cathode assembly of an X-ray tube comprises an emitter assembly including an emitter coupled to an emitter support structure, and an electrode assembly including an electrode stack and a plurality of bias electrodes. The emitter assembly including a plurality of independent components that are coupled together. The electrode assembly including a plurality of independent components that are coupled together, and the emitter assembly being coupled to the electrode assembly.

Abstract: A patient support may be adjustable in height, width, length or a combination thereof. The patient support may be usable with normal sized patients or with bariatric patients. The patient support has a variety of features to enhance operability and/or functionality, including a width adjustable caster frame, width adjustable deck portions, a width adjustable headboard and an extendible foot board to provide extra length. An enhanced lift mechanism can accommodate bariatric patients and alternative functionality in achieving deck positions improves patient comfort. Various parts of the patient support including deck panels and the footboard may be removed and replaced with ease without complicated connectors.

Abstract: Methods, systems and techniques for the accurate measurement breath-borne biomarkers are disclosed. Such methods, systems and techniques may be used for the purposes of detection and/or measurement in breath samples of biomarkers.

Abstract: The present invention includes a hybrid propulsion system for an aircraft comprising: an engine disposed within a fuselage of the aircraft, two electrical generators disposed within the fuselage and connected to the engine, and two nacelles. Each nacelle comprises a proprotor, and each nacelle houses two electric motors connected to the proprotor. Each electrical generator is connected to the two electric motors in each nacelle. The proprotors provide lift for vertical takeoff and landing in a helicopter mode. A fan is coupled to the fuselage and connected to two additional electric motors. Each additional electric motor is connected to one of the two electric generators. The fan provides thrust for forward flight during an airplane mode. The airplane mode includes increasing power to the fan while decreasing power to the proprotors to zero.

Abstract: A vehicle drive system includes a first prime mover, a transmission, a power take-off (PTO), a lubrication system for the transmission and the PTO, and a control system. The transmission is powered by the first prime mover. The transmission is configured to rotate a drive shaft of the vehicle. The PTO is connected to the transmission at a first interface. The PTO includes the first interface and a second interface. The control system is configured to control fluid flow through the lubrication system for at least one mode where the input section of the PTO is stationary and the output section rotates.

Abstract: Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

Abstract: A method for providing overspeed protection for a gas turbine engine having an engine shaft includes monitoring, via an overspeed protection system, a torque of the engine shaft. The method also includes determining, via the overspeed protection system, at least one additional condition of the engine shaft. Further, the method includes determining, via the overspeed protection system, an overspeed condition of the gas turbine engine when the torque of the engine shaft drops below a torque threshold and the at least one additional condition of the engine shaft is indicative of the gas turbine engine being in an operational state. Thus, the overspeed condition is indicative of an above normal rotational speed of the engine shaft. In addition, the method includes initiating a shutdown procedure for the gas turbine engine in response to the determined overspeed condition to reduce the rotational speed of the engine shaft.

Abstract: Provided is a method of transportation information exchange that includes receiving first data from a first aviation data source, such that the first data is provided in a first data format type and determining, based on a set of routing rules, a first aviation consumer of at least a first portion of the first data. The method further includes processing the first portion of the first data into a second data format type associated with the first aviation consumer and providing the first portion of the first data in the second data format type to the first aviation consumer.

Abstract: Various embodiments are directed to processing and executing digital asset transfers between two users. An example method includes receiving a data object defining a digital asset transfer, and the data object may be a query from the first user to initiate an outbound transfer to a second user or an approval of a request for digital asset units from the second user. The method further includes retrieving account balance data objects associated with the digital asset accounts for the first and second users. The method further includes, responsive to determining that the digital asset transfer satisfies one or more transfer conditions, executing the digital asset transfer by executing a closed-loop debit from the first user and executing a closed-loop credit to the second user. The method further includes updating the account balance data object to reflect the resulting balances of each digital asset account.

Abstract: A charged particle buncher includes a series of spaced apart electrodes arranged to generate a shaped electric field. The series includes a first electrode, a last electrode and one- or more intermediate electrodes. The charged particle buncher includes a waveform device attached to the electrodes and configured to apply a periodic potential waveform to each electrode independently in a manner so as to form a quasi-electrostatic time varying potential gradient between adjacent electrodes and to cause spatial distribution of charged particles that form a plurality of nodes and antinodes. The nodes have a charged particle density and the antinodes have substantially no charged particle density, and the nodes and the antinodes are formed from a charged particle beam configured to hit the target.

Abstract: Mobile management method, system and client. Method includes receiving a DNS query for a host name from an application on client; retrieving reputation data associated with host name from a local cache on client; and determining a policy based on host name and the reputation data. Based on determined policy for the host name, blocking attempted network flows to a host corresponding to host name to produce blocked attempted network flows. Method also includes sending attempted network flow metadata related to the blocked attempted network flows to a collector on client; transmitting the attempted network flow metadata from the collector to a VPN server pool via a VPN tunnel; and producing an anomaly report from the transmitted attempted network flow metadata. The anomaly report includes at least one of anomalies, cohorts, trends, location boundaries, detected network security issues, detected compromised clients and/or optimized network usage.

Abstract: An unmanned aerial vehicle (UAV) controller may have control elements configured to receive inputs from a user. A cover may be coupled to the controller. The cover may be movable between a closed position in which the control elements are covered and an open position in which the control elements are exposed. An antenna may be integrated in the cover. The antenna may be electrically connected to circuitry in the controller for communicating with a UAV. In some implementations, a conductive plane and/or an insulating plane may be integrated in the cover. In some implementations, a heatsink, a fan, and/or a support mechanism may be arranged on an under portion of the controller. In some implementations, a circuit board including a cutout may be arranged inside the controller.

Abstract: The present disclosure relates to a label-placement module having a first feeder assembly, including a horizontal delivery platter for receiving a label, and a first drive wheel, positioned adjacent to a distal end of the horizontal delivery platter and rotatable to move the label on the horizontal delivery platter in a first direction. The label-placement module may include a second feeder assembly coupled to an actuator that moves the second feeder assembly vertically to a delivery position associated with the container. The second feeder assembly having a vertical delivery platter for receiving the label from the horizontal delivery platter and a second drive wheel rotatable to move the label forward in the first direction towards the container such that at least a portion of the label may be clamped between the container and a lid of the container thereby attaching the label to the container.

Abstract: A shower/commode wheeled chair adapted to be locatable over a commode, the shower/commode wheeled chair comprising a frame, a seat support portion, a front portion extending downwardly from the seat support portion, a back support, a shower/commode seat, wheels and a footrest coupled to the front portion.

Abstract: Various embodiments of the present disclosure are generally directed to processing conversions of digital assets to fiat currency. An example method includes obtaining a conversion rate for a digital asset via an API, providing the conversion rate via a client device, receiving a digital asset conversion request and executing a digital asset conversion within a configurable time period. Executing the digital asset conversion includes causing digital asset units to be debited from the digital asset user account and causing fiat currency units to be credited to a fiat currency user account. The method further includes dynamically providing a notification of execution of the digital asset conversion via the client device, updating account balance data objects associated with the digital asset user account and the fiat currency user account, and subsequent to executing the digital asset conversion, executing a fiat currency transaction (e.g., a settlement) with a digital asset exchange system.

Abstract: In an aspect, a latch for a closure panel for a vehicle is provided, and includes a ratchet, pawl, release lever, and extension member. The ratchet is movable between a primary closed position, secondary closed position and open position. The pawl is movable between a primary locking position, secondary locking position and unlocking position. The release lever is movable between home and actuated positions. When the pawl is in the primary locking position the release lever has a selected amount of reach for driving the pawl to the secondary locking position during movement of the release lever to the actuated position. When the pawl is in the secondary locking position the extension member is movable to extend the reach of the release lever to drive the pawl from the secondary locking position to the unlocked position during movement of the release lever from the home position to the actuated position.

Abstract: This disclosure relates to methods, non-transitory computer readable media, and systems that relay domain-event objects within an enhanced multi-platform data stream to listen for and react to digital events indicated by the domain-event objects that occur across a wide variety of computing platforms. Specifically, the disclosed systems can receive domain-event objects within the multi-platform data stream. From among the domain-even objects transmitted through the multi-platform data stream, the disclosed systems can identify a domain-event object that is relevant to a digital-analytics platform by identifying domain-event objects that include properties satisfying domain-event-listener rules. Based on an entity identifier and an object event from the relevant domain-event object, the disclosed systems can perform a platform action within the digital-analytics platform (e.g., to react to a change in another platform as indicated by the domain-event object).

Abstract: Provided herein is an engagement and care support platform (“ECSP”) computer system including at least one processor in communication with at least one memory device for facilitating senior user engagement. The processor is programmed to: (i) register a user through an application, (ii) register a caregiver associated with the user through the application, (iii) generate a senior profile based upon user personal and scheduling data, (iv) build a daily interactive user interface that reflects the senior profile, (v) display the daily interactive user interface at a first client device associated with the user, (vi) cause the first client device to initiate a daily interaction prompt to the user, (vii) determine whether any user interaction was received in response to the daily interaction prompt, and (viii) transmit a daily update message to a second client device associated with the caregiver, including an indication of whether any user interaction was received.