Patents by Inventor Joseph Cortese

Joseph Cortese has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-aminoindole compounds and methods for the treatment of malaria
    Patent number: 8980926
    Abstract: The present invention relates to methods of treating a subject with malaria comprising administering a 2-aminoindole compound represented by Formula: (I)—The values and preferred values of the variables in Structural Formula I are defined herein.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: March 17, 2015
    Assignees: Genzyme Corporation, President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: Ralph Mazitschek, Jon C. Clardy, Dyann Wirth, Roger Wiegand, Sameer Urgaonkar, Mary Lynn Baniecki, Joseph Cortese, Cassandra Celatka, Yibin Xiang, Renato Skerlj, Elyse M. J. Bourque
  • Small molecule inhibitors of dihydroorotate dehydrogenase
    Patent number: 8703811
    Abstract: Inhibitors of dihydroorotate dehydrogenase (DHODH) for the Plasmodium enzyme have been identified and characterized. The inhibitors have high specificity, submicromolar efficacy against cultured parasite strains, exhibit drug-like properties, and are not overtly cytotoxic.
    Type: Grant
    Filed: May 7, 2009
    Date of Patent: April 22, 2014
    Assignees: Genzyme Corporation, Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Cecilia Bastos, Michael L. Booker, Cassandra A. Celatka, Jon C. Clardy, Joseph Cortese, Vishal P. Patel, Renato Skerlj, Roger C. Wiegand, Dyann F. Wirth
  • 2-Aminoindole Compounds And Methods For The Treatment Of Malaria
    Publication number: 20120232063
    Abstract: The present invention relates to methods of treating a subject with malaria comprising administering a 2-aminoindole compound represented by Formula: (I)—The values and preferred values of the variables in Structural Formula I are defined herein.
    Type: Application
    Filed: October 28, 2010
    Publication date: September 13, 2012
    Inventors: Ralph Mazitschek, Jon C. Clardy, Dyann Wirth, Roger Wiegand, Sameer Urgaonkar, Mary Lynn Baniecki, Joseph Cortese, Cassandra Celatka, Yibin Xiang, Renato Skerlj, Elyse M.J. Bourque
  • SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE
    Publication number: 20110130381
    Abstract: Inhibitors of dihydroorotate dehydrogenase (DHODH) for the Plasmodium enzyme have been identified and characterized. The inhibitors have high specificity, submicromolar efficacy against cultured parasite strains, exhibit drug-like properties, and are not overtly cytotoxic.
    Type: Application
    Filed: May 7, 2009
    Publication date: June 2, 2011
    Inventors: Cecilia Bastos, Michael L. Booker, Cassandra A. Celatka, Jon C. Clardy, Joseph Cortese, Vishal P. Patel, Renato Skerlj, Roger C. Wiegand, Dyann F. Wirth
  • Procedure and device enabling facile tooth impression
    Publication number: 20070218421
    Abstract: A procedure and device for enabling an accurate impression of a tooth by forcing the gingival sulcus tissue to predominantly compress rather than retract by utilizing a relatively hard shell in conjunction with an absorbent liner and imbibing/mixing the liner material with an astringent for hemostasis, an anesthetic to decrease patient discomfort and an antibiotic to minimize infection, and facilitate gingival healing. A procedure that will decrease postoperative discomfort and maximize periodontal health.
    Type: Application
    Filed: February 2, 2007
    Publication date: September 20, 2007
    Inventors: Subhash Narang, Joseph Cortese