Patents by Inventor Joseph E. Zambanini
Joseph E. Zambanini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11904289Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutiType: GrantFiled: December 22, 2020Date of Patent: February 20, 2024Assignee: Cardinal Health 414, LLCInventors: Dennis Eshima, Mehmet Husnu, James Stone, Derrick Alcaide, Joseph E. Zambanini, Thomas A. Klausing, Chad E. Bouton, Henry Padgett, Brian C. Kelley, Scott N. Danhof, David A. Holley, Jeffrey T. Stroup, James B. Gleeson, Eric Hassenpflug, James A. Prescott, Herman Benecke, Daniel B. Garbark
-
Publication number: 20210187467Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutiType: ApplicationFiled: December 22, 2020Publication date: June 24, 2021Inventors: Dennis ESHIMA, Mehmet HUSNU, James STONE, Derrick ALCAIDE, Joseph E. ZAMBANINI, Thomas A. KLAUSING, Chad E. BOUTON, Henry PADGETT, Brian C. KELLEY, Scott N. DANHOF, David A. HOLLEY, Jeffrey T. STROUP, James B. GLEESON, Eric HASSENPFLUG, James A. PRESCOTT, Herman BENECKE, Daniel B. GARBARK
-
Patent number: 10906020Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutiType: GrantFiled: September 30, 2015Date of Patent: February 2, 2021Assignee: CARDINAL HEALTH 414, LLCInventors: Dennis Eshima, Mehmet Husnu, James Stone, Derrick Alcaide, Joseph E. Zambanini, Thomas A. Klausing, Chad E. Bouton, Henry Padgett, Brian C. Kelley, Scott N. Danhof, David A. Holley, Jeffrey T. Stroup, James B. Gleeson, Eric Hassenpflug, James A. Prescott, Herman Benecke, Daniel B. Garbark
-
Publication number: 20160263545Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutiType: ApplicationFiled: September 30, 2015Publication date: September 15, 2016Applicant: CARDINAL HEALTH 414, LLCInventors: DENNIS ESHIMA, MEHMET HUSNU, JIM STONE, DERRICK ALCAIDE, JOSEPH E. ZAMBANINI, THOMAS A. KLAUSING, CHAD E. BOUTON, HENRY PADGETT, BRIAN C. KELLEY, SCOTT N. DANHOF, DAVID A. HOLLEY, JEFFREY T. STROUP, JAMES B. GLEESON, ERIC HASSENPFLUG, JAMES A. PRESCOTT, HERMAN BENECKE, DANIEL B. GARBARK
-
Publication number: 20160001246Abstract: Compact modular cassette systems and methods for the synthesis of radiopharmaceutical products are provided, the compact modular cassette system including a modular unit having valve plates, a reaction cassette, a reagent pack, and other seal and connector plates to ensure that reagents can be mixed together inside one or more chambers of the reaction cassette in a timely and efficient manner. When a new chamber for each new reaction or process should be used, a valveless modular system having removable reaction cassettes and the reagent packs may be used. In such a system, the reagent container, the reaction cassette, or both, can be removed from the modular cassette system and discarded after a desired reaction or process has taken place.Type: ApplicationFiled: March 2, 2015Publication date: January 7, 2016Applicant: CARDINAL HEALTH 414, LLCInventors: THOMAS A. KLAUSING, BRIAN C. KELLEY, JOSEPH E. ZAMBANINI, DAVID A. HOLLEY, JEFFREY T. STROUP
-
Publication number: 20130102772Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutiType: ApplicationFiled: July 16, 2012Publication date: April 25, 2013Applicant: CARDINAL HEALTH 414, LLCInventors: Dennis ESHIMA, Mehmet Husnu, Jim Stone, Derrick Alcaide, Henry Padgett, Joseph E. Zambanini, Thomas A. Klausing, Chad E. Bouton, Brian C. Kelley, Scott N. Danhof, David A. Holley, Jeffrey T. Stroup, James B. Gleeson, Eric Hassenpflug, James A. Prescott, Herman Benecke, Daniel B. Garbark
-
Publication number: 20130020727Abstract: Compact modular cassette systems and methods for the synthesis of radiopharmaceutical products are provided, the compact modular cassette system including a modular unit having valve plates, a reaction cassette, a reagent pack, and other seal and connector plates to ensure that reagents can be mixed together inside one or more chambers of the reaction cassette in a timely and efficient manner. When a new chamber for each new reaction or process should be used, a valveless modular system having removable reaction cassettes and the reagent packs may be used. In such a system, the reagent container, the reaction cassette, or both, can be removed from the modular cassette system and discarded after a desired reaction or process has taken place.Type: ApplicationFiled: July 16, 2012Publication date: January 24, 2013Applicant: CARDINAL HEALTH 414, LLC.Inventors: Thomas A. KLAUSING, Jeffrey T. STROUP, Brian C. KELLEY, Joseph E. ZAMBANINI, David A. HOLLEY
-
Publication number: 20120080540Abstract: A cartridge for a handheld electrohydrodynamic (EHD) spraying device. The cartridge is disposable, and can contain therapeutic products. The device includes a wetted lead screw with a compliant seal, where the placement of the seal relative to the screw inhibits leakage during both cartridge use and storage. A frame disposed within the cartridge acts as a load-transferring mechanism for the weight of the cartridge to a handle of the spraying device.Type: ApplicationFiled: December 7, 2011Publication date: April 5, 2012Applicant: Battelle Memorial InstituteInventors: James J. Lind, Gregory Trees, Joseph E. Zambanini, Brian Graham, R. Reade Harpham
-
Patent number: 8083161Abstract: A cartridge for a handheld electrohydrodynamic (EHD) spraying device and a spraying device incorporating the cartridge. The cartridge is disposable, and can contain therapeutic products. The device includes a wetted lead screw with a compliant seal, where the placement of the seal relative to the screw inhibits leakage during both cartridge use and storage. A frame disposed within the cartridge acts as a load-transferring mechanism for the weight of the cartridge to a handle of the spraying device.Type: GrantFiled: January 19, 2010Date of Patent: December 27, 2011Assignee: Battelle Memorial InstituteInventors: James J. Lind, Gregory Trees, Joseph E. Zambanini, Brian Graham, R. Reade Harpham
-
Publication number: 20100128944Abstract: The present invention relates to the analysis of specimens. Specifically, the invention relates to methods and apparatus for reviewing specimen slides, including apparatus for holding the slides. The invention also relates to an automatic focusing method for an imaging system and methods for accommodating vibration in the imaging system. In particular, the methods and apparatus may be applied to the automated analysis of cytological specimen slides.Type: ApplicationFiled: January 27, 2010Publication date: May 27, 2010Applicant: CYTYC CORPORATIONInventors: David Zahniser, Theodore S. Geiselman, Roy Ostgaard, Howard L. Greene, Joseph E. Zambanini, Joseph A. Juratovac, Matthew S. Zelinski, Scott N. Danhof, Eric Hassenpflug, Thomas D. Haubert, Randal Chinnock
-
Publication number: 20100116897Abstract: A cartridge for a handheld electrohydrodynamic (EHD) spraying device and a spraying device incorporating the cartridge. The cartridge is disposable, and can contain therapeutic products. The device includes a wetted lead screw with a compliant seal, where the placement of the seal relative to the screw inhibits leakage during both cartridge use and storage. A frame disposed within the cartridge acts as a load-transferring mechanism for the weight of the cartridge to a handle of the spraying device.Type: ApplicationFiled: January 19, 2010Publication date: May 13, 2010Applicant: BATTELLE MEMORIAL INSTITUTEInventors: James J. Lind, Gregory Trees, Joseph E. Zambanini, Brian Graham, R. Reade Harpham
-
Patent number: 7673819Abstract: A cartridge for a handheld electrohydrodynamic (EHD) spraying device and a spraying device incorporating the cartridge. The cartridge is disposable, and can contain therapeutic products. The device includes a wetted lead screw with a compliant seal, where the placement of the seal relative to the screw inhibits leakage during both cartridge use and storage. A frame disposed within the cartridge acts as a load-transferring mechanism for the weight of the cartridge to a handle of the spraying device.Type: GrantFiled: June 26, 2006Date of Patent: March 9, 2010Assignee: Battelle Memorial InstituteInventors: James J. Lind, Gregory Trees, Joseph E. Zambanini, Brian Graham, R. Reade Harpham
-
Publication number: 20090277970Abstract: A cartridge for a spraying device, as well as a spraying device incorporating the cartridge. The cartridge includes fluid reservoir a wetted lead screw and piston that upon rotation can pressurize a fluid within the reservoir. A self-actuating seal is placed between the piston and the lead screw, and extends into the reservoir such that the pressurized fluid applies a compressive force to the outer surface of the seal, causing the seal to clamp down on the lead screw. Such sealing is especially beneficial in electrohydrody?amic spraying devices and electrostatic spraying devices.Type: ApplicationFiled: June 26, 2007Publication date: November 12, 2009Applicant: BATTELLE MEMORIAL INSTITUTEInventors: James J. Lind, Gregory Trees, Joseph E. Zambanini
-
Patent number: 7590492Abstract: Methods, systems, and computer software for screening and assisting in screening biological specimens. Images of a biological specimen are obtained, and image data is generated from the images. Objects of interest (OOI) are identified from the image data. The OOIs are assigned to each of a plurality of fields of interest (FOIs), at least partially based on the assignment of OOIs to other FOIs. For example, OOIs that have not previously been assigned to other FOIs can be assigned to a selected FOI. In this manner, the OOIs can be grouped within the FOIs to maximize the number of OOIs included within FOIs, or alternatively, to minimize the number of FOIs required to include all of the OOIs. Once assignment of the OOIs is complete, a field of view (FOV) can be scanned relative to each FOI in order to present the OOIs to a technician, such as a cytotechnologist.Type: GrantFiled: June 10, 2004Date of Patent: September 15, 2009Assignee: CYTYC CorporationInventors: David J. Zahniser, Garrick L. Maenle, William J. Knox, Jr., Ted S. Geiselman, Howard L. Greene, Matthew S. Zelinski, Joseph E. Zambanini
-
Publication number: 20080083845Abstract: A cartridge for a handheld electrohydrodynamic (EHD) spraying device and a spraying device incorporating the cartridge. The cartridge is disposable, and can contain therapeutic products. The device includes a wetted lead screw with a compliant seal, where the placement of the seal relative to the screw inhibits leakage during both cartridge use and storage. A frame disposed within the cartridge acts as a load-transferring mechanism for the weight of the cartridge to a handle of the spraying device.Type: ApplicationFiled: June 26, 2006Publication date: April 10, 2008Applicant: Battelle Memorial InstituteInventors: James J. Lind, Gregory Trees, Joseph E. Zambanini, Brian Graham, R. Reade Harpham
-
Publication number: 20040254738Abstract: Methods, systems, and computer software for screening and assisting in screening biological specimens. Images of a biological specimen are obtained, and image data is generated from the images. Objects of interest (OOI) are identified from the image data. The OOIs are assigned to each of a plurality of fields of interest (FOIs), at least partially based on the assignment of OOIs to other FOIs. For example, OOIs that have not previously been assigned to other FOIs can be assigned to a selected FOI. In this manner, the OOIs can be grouped within the FOIs to maximize the number of OOIs included within FOIs, or alternatively, to minimize the number of FOIs required to include all of the OOIs. Once assignment of the OOIs is complete, a field of view (FOV) can be scanned relative to each FOI in order to present the OOIs to a technician, such as a cytotechnologist.Type: ApplicationFiled: June 10, 2004Publication date: December 16, 2004Applicant: Cytyc CorporationInventors: David J. Zahniser, Garrick L. Maenle, William J. Knox, Ted S. Geiselman, Howard L. Greene, Matthew S. Zelinski, Joseph E. Zambanini