Abstract: Per- and polyfluoroalkyl substances (PFAS) are destroyed by oxidation in supercritical conditions. PFAS in water can be concentrated and prepared for destruction in a pretreatment phase. Following annihilation of the PFAS in supercritical conditions to levels below 5 parts per trillion (ppt), the water effluent can be used to recover heat, returned to sub-critical conditions, and then released back into the environment.

Abstract: The disclosure features compositions and methods for the treatment of sensorineural hearing loss and auditory neuropathy, particularly forms of the disease that are associated with mutations in otoferlin (OTOF), by way of OTOF gene therapy. The disclosure provides a variety of compositions that include a first nucleic acid vector that contains a polynucleotide encoding an N-terminal portion of an OTOF protein and a second nucleic acid vector that contains a polynucleotide encoding a C-terminal portion of an OTOF protein. These vectors can be used to increase the expression of OTOF in a subject, such as a human subject suffering from sensorineural hearing loss.

Abstract: This invention relates to compounds of Formula (I): and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein L1, L2, R1, R2, R3 and n are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Abstract: A native restart controller restarts services in a controlled manner. The services run in a cloud computing environment comprising a plurality of computing devices executing a plurality of Kubernetes pods comprising one or more containers. An indication is received of a deployment defining a service to be implemented in the cloud computing environment, the deployment including a desired number of instances of the service. An API is instantiated that is operable to provide a first state indicative of whether restarts are to be controlled by the restart controller and a second state indicating that a restart is required. In response to receiving an indication that restarts for the cluster are to be controlled by the restart controller and that a restart is required, the instances are restarted in a sequence in accordance with restart criteria associated with the service.

Abstract: A method for surface modification of a titanium substrate or a titanium alloy substrate comprising: a) applying at least one beta phase stabiliser to a surface of the titanium substrate or titanium alloy substrate; and b) heating the surface so as to alloy titanium with the at least one beta phase stabiliser.

Abstract: An apparatus such as a robot capable of performing goal oriented tasks may include one or more touch sensors to receive touch perception feedback on the location of objects and structures within an environment. A fusion engine may be configured to combine touch perception data with other types of sensor data such as data received from an image or distance sensor. The apparatus may combine distance sensor data with touch sensor data using inference models such as Bayesian inference. The touch sensor may be mounted onto an adjustable arm of a robot. The apparatus may use the data it has received from both a touch sensor and distance sensor to build a map of its environment and perform goal oriented tasks such as cleaning or moving objects.

Abstract: Techniques are described for generating a virtualized network function (VNF) descriptor (VNFD) indicative of resources for managing VNF components (VNFCs) across a plurality of virtualized infrastructure managers (VIMs) implemented in a virtualized computing environment configured in a user-specific configuration. A VNFD generator receives a solution description file (SDF) encoding user input pertaining to the user-specific configuration, and a VNFC descriptor encoding VNFC specific information. The SDF and VNFC descriptor are validated and translated to generate an abstracted VNFD that is independent of renderers implemented at the virtualized computing environment. The abstracted VNFD is translated to a VNFD that is specific to the renderers and VIM and VNFD-specific information at the virtualized computing environment.

Abstract: Techniques for providing a credential of a secure data network to a computing device are described. In an example, a system stores an association between the computing device and a user account. The user account is also associated with a credential of the secure data network. The system receives a certificate of the computing device and determines the association between the computing device and the user account based on the certificate. Further, the system authenticates the computing device based on the association being determined to send to the computing device data, where this data is verified based on a private key of the system. The system receives a request of the computing device for the credential based on the data and sends the credential to the computing device.

Abstract: Systems and methods are provided for data migration. The system may comprise one or more processors and a memory storing instructions that, when executed by the one or more processors, cause the system to migrate at least one first table of a first database schema to at least one second table of a second database schema, determine a query for modifying the first table during the migration, modify the second table based at least in part on the query, and update a mutation table to describe the modification, wherein the mutation table at least describes the modification.

Abstract: A native restart controller restarts services in a controlled manner. The services run in a cloud computing environment comprising a plurality of computing devices executing a plurality of Kubernetes pods comprising one or more containers. An indication is received of a deployment defining a service to be implemented in the cloud computing environment, the deployment including a desired number of instances of the service. An API is instantiated that is operable to provide a first state indicative of whether restarts are to be controlled by the restart controller and a second state indicating that a restart is required. In response to receiving an indication that restarts for the cluster are to be controlled by the restart controller and that a restart is required, the instances are restarted in a sequence in accordance with restart criteria associated with the service.

Abstract: System and method for model orchestration and sensor correlation according to certain embodiments. For example, a method includes: accessing a plurality of models, each model of the plurality of models configured to process data; receiving information corresponding to a plurality of sensors associated with a plurality of edge devices; selecting one or more models from the plurality of models based on a processing request; selecting one or more sensors from the plurality of sensors based on the processing request; building one or more model pipelines based at least in part on the one or more selected models and the one or more selected sensors; and deploying the one or more model pipelines.

Abstract: A native restart controller restarts services in a controlled manner. The services run in a cloud computing environment comprising a plurality of computing devices executing a plurality of Kubernetes pods comprising one or more containers. An indication is received of a deployment defining a service to be implemented in the cloud computing environment, the deployment including a desired number of instances of the service. An API is instantiated that is operable to provide a first state indicative of whether restarts are to be controlled by the restart controller and a second state indicating that a restart is required. In response to receiving an indication that restarts for the cluster are to be controlled by the restart controller and that a restart is required, the instances are restarted in a sequence in accordance with restart criteria associated with the service.

Abstract: Techniques are described for generating a virtualized network function (VNF) descriptor (VNFD) indicative of resources for managing VNF components (VNFCs) across a plurality of virtualized infrastructure managers (VIMs) implemented in a virtualized computing environment configured in a user-specific configuration. A VNFD generator receives a solution description file (SDF) encoding user input pertaining to the user-specific configuration, and a VNFC descriptor encoding VNFC specific information. The SDF and VNFC descriptor are validated and translated to generate an abstracted VNFD that is independent of renderers implemented at the virtualized computing environment. The abstracted VNFD is translated to a VNFD that is specific to the renderers and VIM and VNFD-specific information at the virtualized computing environment.

Abstract: A database system comprised of a decoupled compute layer and storage layer is implemented to store, build, and maintain a canonical dataset, a temporary buffer, and an edits dataset. The canonical dataset is a set of batch updated data. The data is appended in chunks to the canonical dataset such that the canonical dataset becomes a historical dataset over time. The buffer is a write ahead log that contains the most recent chunks of data and provides atomicity and durability for the database system. The edits dataset is the set of data that contains edits such as cell mutations, row appends and/or row deletions. The database system enables users to make cell or row-level edits to tables and observe those edits in analytical systems or downstream builds with minimal latency.

Abstract: Systems and methods are provided for data migration. The system may comprise one or more processors and a memory storing instructions that, when executed by the one or more processors, cause the system to migrate at least one first table of a first database schema to at least one second table of a second database schema, determine a query for modifying the first table during the migration, modify the second table based at least in part on the query, and update a mutation table to describe the modification, wherein the mutation table at least describes the modification.

Abstract: Techniques are described for generating a virtualized network function (VNF) descriptor (VNFD) indicative of resources for managing VNF components (VNFCs) across a plurality of virtualized infrastructure managers (VIMs) implemented in a virtualized computing environment configured in a user-specific configuration. A VNFD generator receives a solution description file (SDF) encoding user input pertaining to the user-specific configuration, and a VNFC descriptor encoding VNFC specific information. The SDF and VNFC descriptor are validated and translated to generate an abstracted VNFD that is independent of renderers implemented at the virtualized computing environment. The abstracted VNFD is translated to a VNFD that is specific to the renderers and VIM and VNFD-specific information at the virtualized computing environment.

Abstract: A database system comprised of a decoupled compute layer and storage layer is implemented to store, build, and maintain a canonical dataset, a temporary buffer, and an edits dataset. The canonical dataset is a set of batch updated data. The data is appended in chunks to the canonical dataset such that the canonical dataset becomes a historical dataset over time. The buffer is a write ahead log that contains the most recent chunks of data and provides atomicity and durability for the database system. The edits dataset is the set of data that contains edits such as cell mutations, row appends and/or row deletions. The database system enables users to make cell or row-level edits to tables and observe those edits in analytical systems or downstream builds with minimal latency.

Abstract: A native restart controller restarts services in a controlled manner. The services run in a cloud computing environment comprising a plurality of computing devices executing a plurality of Kubernetes pods comprising one or more containers. An indication is received of a deployment defining a service to be implemented in the cloud computing environment, the deployment including a desired number of instances of the service. An API is instantiated that is operable to provide a first state indicative of whether restarts are to be controlled by the restart controller and a second state indicating that a restart is required. In response to receiving an indication that restarts for the cluster are to be controlled by the restart controller and that a restart is required, the instances are restarted in a sequence in accordance with restart criteria associated with the service.

Abstract: Techniques are described for generating a virtualized network function (VNF) descriptor (VNFD) indicative of resources for managing VNF components (VNFCs) across a plurality of virtualized infrastructure managers (VIMs) implemented in a virtualized computing environment configured in a user-specific configuration. A VNFD generator receives a solution description file (SDF) encoding user input pertaining to the user-specific configuration, and a VNFC descriptor encoding VNFC specific information. The SDF and VNFC descriptor are validated and translated to generate an abstracted VNFD that is independent of renderers implemented at the virtualized computing environment. The abstracted VNFD is translated to a VNFD that is specific to the renderers and VIM and VNFD-specific information at the virtualized computing environment.

Abstract: An apparatus such as a robot capable of performing goal oriented tasks may include one or more touch sensors to receive touch perception feedback on the location of objects and structures within an environment. A fusion engine may be configured to combine touch perception data with other types of sensor data such as data received from an image or distance sensor. The apparatus may combine distance sensor data with touch sensor data using inference models such as Bayesian inference. The touch sensor may be mounted onto an adjustable arm of a robot. The apparatus may use the data it has received from both a touch sensor and distance sensor to build a map of its environment and perform goal oriented tasks such as cleaning or moving objects.