Patents by Inventor Joseph F. Poduslo

Joseph F. Poduslo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide-Mediated Non-Covalent Delivery of Active Agents Across the Blood-Brain Barrier
    Publication number: 20190322723
    Abstract: The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents.
    Type: Application
    Filed: July 3, 2019
    Publication date: October 24, 2019
    Inventors: Geoffry L. Curran, Gobinda Sarkar, Joseph F. Poduslo, Robert B. Jenkins, Val J. Lowe, Eric W. Mahlum
  • Peptide-mediated non-covalent delivery of active agents across the blood-brain barrier
    Patent number: 10377813
    Abstract: The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: August 13, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Geoffry L. Curran, Gobinda Sarkar, Joseph F. Poduslo, Robert B. Jenkins, Val J. Lowe, Eric W. Mahlum
  • Peptide-Mediated Non-Covalent Delivery of Active Agents Across the Blood-Brain Barrier
    Publication number: 20170145076
    Abstract: The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents.
    Type: Application
    Filed: February 2, 2017
    Publication date: May 25, 2017
    Inventors: Geoffry L. Curran, Gobinda Sarkar, Joseph F. Poduslo, Robert B. Jenkins, Val J. Lowe, Eric W. Mahlum
  • Peptide-mediated non-covalent delivery of active agents across the blood-brain barrier
    Patent number: 9597408
    Abstract: The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: March 21, 2017
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Geoffry L. Curran, Gobinda Sarkar, Joseph F. Poduslo, Robert B. Jenkins, Val J. Lowe, Erik W. Mahlum
  • Magnetic resonance imaging of amyloid plaque in the brain
    Patent number: 9320452
    Abstract: Amyloid plaque in the brain of a subject is imaged in an MRI system with or without the use of a contrast agent. Contrast is achieved using a spin-echo pulse sequence that is both respiratory gated and cardiac gated to reduce motion artifacts at the very high image resolution required to see plaque. A preparatory pulse sequence is used to insure longitudinal magnetization remains constant for all the acquired views even if the effective TR changes during the scan due to irregular breathing.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: April 26, 2016
    Assignees: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Michael G. Garwood, Clifford R. Jack, Jr., Joseph F Poduslo, Thomas M. Wengenack
  • Peptide-Mediated Non-Covalent Delivery of Active Agents Across the Blood-Brain Barrier
    Publication number: 20140328866
    Abstract: The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents.
    Type: Application
    Filed: May 19, 2014
    Publication date: November 6, 2014
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Geoffry L. Curran, Gobinda Sarkar, Joseph F. Poduslo, Robert B. Jenkins, Val J. Lowe, Erik W. Mahlum
  • PEPTIDE-MEDIATED NON-COVALENT DELIVERY OF ACTIVE AGENTS ACROSS THE BLOOD-BRAIN BARRIER
    Publication number: 20120107243
    Abstract: The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents.
    Type: Application
    Filed: July 14, 2010
    Publication date: May 3, 2012
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Geoffry L. Curran, Gobinda Sarkar, Joseph F. Poduslo, Robert B. Jenkins, Val J. Lowe, Eric W. Mahlum
  • Treatment for central nervous system disorders
    Patent number: 7988969
    Abstract: Compositions that include an A? polypeptide linked to a non-A? polypeptide are described, as well as methods of using such compositions.
    Type: Grant
    Filed: August 31, 2009
    Date of Patent: August 2, 2011
    Assignee: MAYO Foundation for Medical Education and Research
    Inventors: Joseph F. Poduslo, Geoffry L. Curran
  • Treatment for Central Nervous System Disorders
    Publication number: 20090324492
    Abstract: Compositions that include an A? polypeptide linked to a non-A? polypeptide are described, as well as methods of using such compositions.
    Type: Application
    Filed: August 31, 2009
    Publication date: December 31, 2009
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Joseph F. Poduslo, Geoffry L. Curran
  • Methods for detecting parenchymal plaques in vivo
    Publication number: 20090028789
    Abstract: Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity for the extracellular deposit, to the living mammal. Isolated ?-amyloid peptides that are polyamine modified and labeled with a radioisotope or contrast agent also are described.
    Type: Application
    Filed: January 18, 2008
    Publication date: January 29, 2009
    Inventors: Joseph F. Poduslo, Geoffry L. Curran, Thomas M. Wengenack
  • Magnetic Resonance Imaging of Amyloid Plaque in the Brain
    Publication number: 20080262339
    Abstract: Amyloid plaque in the brain of a subject is imaged in an MRI system with or without the use of a contrast agent. Contrast is achieved using a spin-echo pulse sequence that is both respiratory gated and cardiac gated to reduce motion artifacts at the very high image resolution required to see plaque. A preparatory pulse sequence is used to insure longitudinal magnetization remains constant for all the acquired views even if the effective TR changes during the scan due to irregular breathing.
    Type: Application
    Filed: June 28, 2005
    Publication date: October 23, 2008
    Inventors: Michael G. Garwood, Clifford R. Jack, Joseph F. Poduslo, Thomas M. Wengenack
  • Methods for detecting parenchymal plaques in vivo
    Patent number: 7371365
    Abstract: Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity for the extracellular deposit, to the living mammal. Isolated ?-amyloid peptides that are polyamine modified and labeled with a radioisotope or contrast agent also are described.
    Type: Grant
    Filed: January 27, 2003
    Date of Patent: May 13, 2008
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Joseph F. Poduslo, Geoffrey L. Curran, Thomas M. Wengenack
  • Amino acid composition with increased blood brain barrier permeability
    Patent number: 7279149
    Abstract: An amino acid composition with improved blood brain barrier permeability comprising an amino acid polymer, wherein the amino acid comprises at least one asparagyl-4-aminobutane or glutamyl-4-aminobutane residue.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: October 9, 2007
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Joseph F. Poduslo, Geoffrey L. Curran, Thomas M. Wengenack, Daniel J. McCormick, Abdul H. Fauq
  • Treatment for central nervous system disorders
    Publication number: 20040142872
    Abstract: Compositions that include an A&bgr; polypeptide linked to a non-A&bgr; polypeptide are described, as well as methods of using such compositions.
    Type: Application
    Filed: March 9, 2004
    Publication date: July 22, 2004
    Applicant: Mayo Foundation for Medical Education and Research ,a MN corporation
    Inventors: Joseph F. Poduslo, Geoffry L. Curran
  • Methods for detecting parenchymal plaques in vivo
    Publication number: 20040022736
    Abstract: Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity for the extracellular deposit, to the living mammal. Isolated &bgr;-amyloid peptides that are polyamine modified and labeled with a radioisotope or contrast agent also are described.
    Type: Application
    Filed: January 27, 2003
    Publication date: February 5, 2004
    Inventors: Joseph F. Poduslo, Geoffrey L. Curran, Thomas M. Wengenack
  • Treatment for central nervous system disorders
    Publication number: 20030082191
    Abstract: Compositions that include an A&bgr; polypeptide linked to a non-A&bgr; polypeptide are described, as well as methods of using such compositions.
    Type: Application
    Filed: August 29, 2001
    Publication date: May 1, 2003
    Inventors: Joseph F. Poduslo, Geoffry L. Curran
  • Method to enhance permeability of the blood/brain blood/nerve bariers to therapeutic agents
    Patent number: 5670477
    Abstract: A method is provided to enhance the ability of a neurologically active compound to penetrate the blood nerve barrier (BNB) or blood brain barrier (BBB), by administration of a conjugate comprising the neurologically active compound linked to a carrier molecule that has been shown to have a substantial permeability coefficient across the BNB and BBB.
    Type: Grant
    Filed: April 20, 1995
    Date of Patent: September 23, 1997
    Assignees: Joseph F. Poduslo, Geoffrey L. Curran
    Inventors: Joseph F. Poduslo, Geoffrey L. Curran
  • Method to enhance permeability of the blood/brain blood/nerve barriers to therapeutic agents
    Patent number: 5604198
    Abstract: A method is provided to enhance the ability of a neurologically active compound to penetrate the blood nerve barrier (BNB) or blood brain barrier (BBB), by administration of a conjugate comprising the neurologically active compound linked to a carrier molecule that has been shown to have a substantial permeability coefficient across the BNB and BBB.
    Type: Grant
    Filed: May 12, 1994
    Date of Patent: February 18, 1997
    Inventors: Joseph F. Poduslo, Geoffrey L. Curran
  • Method to increase permeability of the blood-nerve/brain barriers to proteins
    Patent number: 5260308
    Abstract: A method is provided to enhance the permeability of the blood-nerve barrier or the blood-brain barrier to neuroactive proteins, comprising glycating said proteins prior to bringing them into contact with said barriers.
    Type: Grant
    Filed: November 6, 1991
    Date of Patent: November 9, 1993
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Joseph F. Poduslo, Geoffrey L. Curran