Patents by Inventor Joseph G. Hacia

Joseph G. Hacia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Probe-based analysis of heterozygous mutations using two-color labelling
    Patent number: 6342355
    Abstract: The invention provides methods of analyzing a nucleic acid in a target sample for variant alleles. In such methods, a first-labelled control sample and a second-labelled target sample are hybridized to at least one set of probes. The control sample comprises a homozygous reference allele. The target sample comprises the homozygous reference allele, or variant alleles differing from the reference allele at a locus, or one variant allele differing from the reference allele at the locus and one reference allele. The probes in the probe set span the locus and are complementary to the reference allele. After hybridization the intensity of first and second label bound to each probe in the set is measured. This information is then used to indicate the presence of one variant allele and one reference allele, or the presence of two variant alleles in the target sample.
    Type: Grant
    Filed: January 5, 2000
    Date of Patent: January 29, 2002
    Assignees: The United States of America as represented by the Department of Health & Human Services, Affymetrix, Inc.
    Inventors: Joseph G. Hacia, Mark S. Chee, Francis S. Collins
  • Probe-based analysis of heterozygous mutations using two-color labelling
    Patent number: 6013449
    Abstract: The invention provides methods of analyzing a nucleic acid in a target sample for variant alleles. In such methods, a first-labelled control sample and a second-labelled target sample are hybridized to at least one set of probes. The control sample comprises a homozygous reference allele. The target sample comprises the homozygous reference allele, or variant alleles differing from the reference allele at a locus, or one variant allele differing from the reference allele at the locus and one reference allele. The probes in the probe set span the locus and are complementary to the reference allele. After hybridization the intensity of first and second label bound to each probe in the set is measured. This information is then used to indicate the presence of one variant allele and one reference allele, or the presence of two variant alleles in the target sample.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: January 11, 2000
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Joseph G. Hacia, Mark S. Chee, Francis S. Collins