Patents by Inventor Joseph Georgeson
Joseph Georgeson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240131121Abstract: The present invention provides a non-naturally occurring composition comprising a CRISPR nuclease comprising a sequence having at least 95% identity to the amino acid sequence of SEQ ID NO: 3 or a nucleic acid molecule comprising a sequence encoding the CRISPR nuclease.Type: ApplicationFiled: April 5, 2023Publication date: April 25, 2024Applicant: EmendoBio Inc.Inventors: David Baram, Lior Izhar, Asael Herman, Liat Rockah, Nadav Marbach-Bar, Nurit Meron, Joseph Georgeson
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Publication number: 20240132881Abstract: RNA molecules comprising a guide sequence portion having 17-20 nucleotides in the sequence of 17-20 contiguous nucleotides set forth in any one of SEQ ID NOs: 1-3010 and compositions, methods, and uses thereof.Type: ApplicationFiled: October 24, 2023Publication date: April 25, 2024Applicant: EmendoBio, Inc.Inventors: Lior Izhar, David Baram, Joseph Georgeson, Michal Golan-Mashiach, Asael Herman, Rafi Emmanuel
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Patent number: 11827879Abstract: RNA molecules comprising a guide sequence portion having 17-20 nucleotides in the sequence of 17-20 contiguous nucleotides set forth in any one of SEQ ID NOs: 1-3010 and compositions, methods, and uses thereof.Type: GrantFiled: November 28, 2018Date of Patent: November 28, 2023Assignee: EmendoBio, Inc.Inventors: Lior Izhar, David Baram, Joseph Georgeson, Michal Golan-Mashiach, Asael Herman, Rafi Emmanuel
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Publication number: 20230175020Abstract: RNA molecules comprising a guide sequence portion having 17-25 contiguous nucleotides containing nucleotides in the sequence set forth in any one of SEQ ID NOs: 1-6601 and compositions, methods, and uses thereof.Type: ApplicationFiled: March 27, 2020Publication date: June 8, 2023Applicant: EmendoBio Inc.Inventors: David Baram, Lior Izhar, Asael Herman, Rafi Emmanuel, Michal Golan Mashiach, Joseph Georgeson
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Patent number: 11666641Abstract: The present invention provides a non-naturally occurring composition comprising a CRISPR nuclease comprising a sequence having at least 95% identity to the amino acid sequence of SEQ ID NO: 3 or a nucleic acid molecule comprising a sequence encoding the CRISPR nuclease.Type: GrantFiled: April 30, 2020Date of Patent: June 6, 2023Assignee: EMENDOBIO INC.Inventors: David Baram, Lior Izhar, Asael Herman, Liat Rockah, Nadav Marbach-Bar, Nurit Meron, Joseph Georgeson
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Publication number: 20220387515Abstract: Methods for inactivating in a cell a mutant allele of the elastase, neutrophil expressed gene (ELANE gene) gene having a mutation associated with severe congenital neutropenia (SCN) or cyclic neutropenia (CyN) and which cell is heterozygous at one or more polymorphic sites selected from the group consisting of: rs10424470, rs4807932, rs10414837, rs376107533, rs3761010, rs351108, rs3826946, rs10413889, rs3761007, rs10409474, rs3761005, rs351107, rs3761001, rs740021, rs781452480, rs371057361, rs570466264, rs1041904080, rs7250194, rs17216649, rs199720952, rs6510983, rs17223066, rs7255385, rs9749274, rs111361200, rs112639467, rs141213775, rs28591229, rs10469327, rs3834645, rs1683564, rs71335276, and rs8107095, the method comprising introducing to the cell a composition comprising: a CRISPR nuclease or a sequence encoding the CRISPR nuclease; and a first RNA molecule comprising a guide sequence portion having 21-30 nucleotides, wherein a complex of the CRISPR nuclease and the first RNA molecule affects a douType: ApplicationFiled: November 5, 2020Publication date: December 8, 2022Applicant: EmendoBio Inc.Inventors: David Baram, Lior Izhar, Asael Herman, Rafi Emmanuel, Liat Rockah, Nadav Marbach Bar, Michal Golan Mashiach, Joseph Georgeson
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Publication number: 20220307057Abstract: RNA molecules comprising a guide sequence portion having 17-25 contiguous nucleotides containing nucleotides in the sequence set forth in any one of SEQ ID NOs: 1-44348 and compositions, methods, and uses thereof.Type: ApplicationFiled: April 14, 2020Publication date: September 29, 2022Applicant: EmendoBio Inc.Inventors: David Baram, Lior Izhar, Asael Herman, Rafi Emmanuel, Michal Golan Mashiach, Joseph Georgeson
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Publication number: 20220267777Abstract: RNA molecules comprising a guide sequence portion having 17-25 contiguous nucleotides in the sequence set forth in any one of SEQ ID NOs: 1-49516 and compositions, methods, and uses thereof.Type: ApplicationFiled: July 10, 2020Publication date: August 25, 2022Applicant: EmendoBio Inc.Inventors: David Baram, Lior Izhar, Asael Herman, Rafi Emmanuel, Michal Golan Mashiach, Joseph Georgeson
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Publication number: 20220213456Abstract: The present invention provides a non-naturally occurring composition comprising a CRISPR nuclease comprising a sequence having at least 95% identity to the amino acid sequence selected from the group consisting of SEQ ID NOs: 1-4 or 149-166 or a nucleic acid molecule comprising a sequence encoding the CRISPR nuclease.Type: ApplicationFiled: April 30, 2020Publication date: July 7, 2022Applicant: EmendoBio Inc.Inventors: David Baram, Lior Izhar, Asael Herman, Liat Rockah, Nadav Marbach-Bar, Nurit Meron, Joseph Georgeson
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Publication number: 20220202913Abstract: The present invention provides a non-naturally occurring composition comprising a CRISPR nuclease comprising a sequence having at least 95% identity to the amino acid sequence of SEQ ID NO: 3 or a nucleic acid molecule comprising a sequence encoding the CRISPR nuclease.Type: ApplicationFiled: April 30, 2020Publication date: June 30, 2022Applicant: EmendoBio Inc.Inventors: David Baram, Lior Izhar, Asael Herman, Liat Rockah, Nadav Marbach-Bar, Nurit Meron, Joseph Georgeson
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Publication number: 20220136013Abstract: RNA molecules comprising a guide sequence portion having 17-25 contiguous nucleotides containing nucleotides in the sequence set forth in any one of SEQ NOs 1-37365 and compositions, methods, and uses thereof.Type: ApplicationFiled: February 25, 2020Publication date: May 5, 2022Applicant: EmendoBio Inc.Inventors: David Baram, Lior Izhar, Asael Herman, Rafi Emmanuel, Michal Golan Mashiach, Joseph Georgeson
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Publication number: 20220098621Abstract: RNA molecules comprising a guide sequence portion having 17-25 contiguous nucleotides containing nucleotides in the sequence set forth in any one of SEQ ID NOs 1-20465 and compositions, methods, and uses thereof.Type: ApplicationFiled: February 4, 2020Publication date: March 31, 2022Applicant: EmendoBio Inc.Inventors: David Baram, Lior Izhar, Asael Herman, Rafi Emmanuel, Michal Golan Mashiach, Joseph Georgeson
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Publication number: 20220064635Abstract: RNA molecules comprising a guide sequence portion having 17-25 nucleotides in the sequence of 20-22 contiguous nucleotides set forth in any one of SEQ ID NOs: 1-12655 and compositions, methods, and uses thereof.Type: ApplicationFiled: January 6, 2020Publication date: March 3, 2022Applicant: EmendoBio Inc.Inventors: David Baram, Asael Herman, Rafi Emmanuel, Michal Golan Mashiach, Joseph Georgeson
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Publication number: 20210363547Abstract: Methods for inactivating in a cell a mutant allele of the elastase, neutrophil expressed gene (ELANE gene) gene having a mutation associated with severe congenital neutropenia (SCN) or cyclic neutropenia (CyN) and which cell is heterozygous at one or more polymorphic sites selected from the group consisting of: rs10414837, rs3761005, rs1683564, rs9749274, rs740021, rs201048029, rs199720952, rs28591229, rs71335276, rs58082177, rs3826946, rs10413889, rs761481944, rs3761008, rs10409474, rs3761007, rs17216649, rs10469327, rs8107095, rs10424470 and rs78302854, the method comprising introducing to the cell a composition comprising: a CRISPR nuclease or a sequence encoding the CRISPR nuclease; and a first RNA molecule comprising a guide sequence portion having 17-20 nucleotides, wherein a complex of the CRISPR nuclease and the first RNA molecule affects a double strand break in the mutant allele of the ELANE gene the method optionally further comprising introduction of a second RNA molecule comprising a guideType: ApplicationFiled: May 6, 2019Publication date: November 25, 2021Applicant: EMENDOBIO INC.Inventors: David Baram, Lior Izhar, Asael Herman, Rafi Emmanuel, Michal Golan Mashiach, Joseph Georgeson
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Publication number: 20210155929Abstract: Methods for inactivating in a cell a mutant allele of the elastase, neutrophil expressed gene (ELANE gene) gene having a mutation associated with severe congenital neutropenia (SCN) or cyclic neutropenia (CyN) and which cell is heterozygous at one or more polymorphic sites selected from the group consisting of: rs10424470, rs4807932, rs10414837, rs376107533, rs3761010, rs10413889, rs3761007, rs10409474, rs3761005, rs351107, rs3761001, rs740021, rs781452480, rs371057361, rs570466264, rs1041904080, rs7250194, rs17216649, rs199720952, rs6510983, rs17223066, rs7255385, rs112639467, rs141213775, rs28591229, rs10469327, rs3834645, rs1683564, rs71335276, and rs8107095, the method comprising introducing to the cell a composition comprising: a CRISPR nuclease or a sequence encoding the CRISPR nuclease; and a first RNA molecule comprising a guide sequence portion having 17-30 nucleotides, wherein a complex of the CRISPR nuclease and the first RNA molecule affects a double strand break in the mutant allele of theType: ApplicationFiled: November 5, 2020Publication date: May 27, 2021Applicant: EmendoBio Inc.Inventors: David Baram, Lior Izhar, Asael Herman, Rafi Emmanuel, Michal Golan Mashiach, Joseph Georgeson
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Publication number: 20210130804Abstract: Methods for inactivating in a cell a mutant allele of the elastase, neutrophil expressed gene (ELANE gene) gene having a mutation associated with severe congenital neutropenia (SCN) or cyclic neutropenia (CyN) wherein the mutant allele is selected from the group consisting of the ELANE mutants set forth in Table 1, the method comprising introducing to the cell a composition comprising: a CRISPR nuclease or a sequence encoding the CRISPR nuclease; and a first RNA molecule comprising a guide sequence portion having 17-30 nucleotides, wherein a complex of the CRISPR nuclease and the first RNA molecule affects a double strand break in the mutant allele of the ELANE gene the method optionally further comprising introduction of a second RNA molecule comprising a guide sequence portion capable of complexing with a CRISPR nuclease, wherein the complex of the second RNA molecule and CRISPR nuclease affects a second double strand break in the ELANE gene.Type: ApplicationFiled: November 5, 2020Publication date: May 6, 2021Applicant: EmendoBio Inc.Inventors: David Baram, Lior Izhar, Asael Herman, Rafi Emmanuel, Liat Rockah, Nadav Marbach-Bar, Michal Golan Mashiach, Joseph Georgeson
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Publication number: 20210032663Abstract: RNA molecules comprising a guide sequence portion having 17-20 nucleotides in the sequence of 17-20 contiguous nucleotides set forth in any one of SEQ ID NOs: 1-1313 and compositions, methods, and uses thereof.Type: ApplicationFiled: March 22, 2019Publication date: February 4, 2021Applicant: EMENDOBIO INC.Inventors: David Baram, Lior Izhar, Asael Herman, Rafi Emmanuel, Michal Golan Mashiach, Joseph Georgeson
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Publication number: 20200332287Abstract: RNA molecules comprising a guide sequence portion having 17-20 nucleotides in the sequence of 17-20 contiguous nucleotides set forth in any one of SEQ ID NOs: 1-1990 and compositions, methods, and uses thereof.Type: ApplicationFiled: November 28, 2018Publication date: October 22, 2020Applicant: EmendoBio Inc.Inventors: Lior Izhar, David Baram, Joseph Georgeson, Michal Golan-Mashiach, Asael Herman, Rafi Emmanuel