Abstract: Filaments that contain a filament-forming material and an additive, nonwoven webs, and methods for making such filaments are provided.

Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.

Abstract: A sensor pod system includes one or more sensor pods with a plurality of sensors configured to collect data from an environment. A sensor pod may have an effective field of view created by individual sensors with overlapping fields of view. The sensor pod system may include sensors of different types and modalities. Sensor pods of the sensor pod system may be modularly installed on a vehicle, for example, an autonomous vehicle and collect and provide data of the environment during operation of the vehicle.

Abstract: A method for delivering one or more oral care active agents to a mammal's mouth using a nonwoven web of filaments and/or fibers containing one or more oral care active agents that are releasable from the filaments and/or fibers is provided.

Abstract: Compounds of formula (I) are described, wherein each of the variable groups is as defined in the specification. Also described are pharmaceutical compositions containing a compound of formula (I), and uses of the compounds and pharmaceutical compositions for inhibiting Nav1.8 voltage-gated sodium channels and treating Nav1.8 mediated diseases, disorders, and conditions, such as pain and pain-associated diseases, disorders, and conditions and cardiovascular diseases, disorders, and conditions, such as atrial fibrillation.

Abstract: A joist assembly system that is structured for dynamic retrieval of components, dynamic and precise positioning and location of retrieved components, assembly of the components to form a joist, and delivery of the assembled joist. The joist assembly system has a plurality of material handling systems, a plurality of welding systems, and a rigging table system. The material handling systems are structured to load and position the components such as chords and webs onto the rigging table. The rigging table in turn supports the chords or webs. Subsequently, the plurality of welding systems weld the webs to the chords to form the joist.

Abstract: The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Abstract: A system and method for a face mask communication system. The face mask communication system includes a removable microphone that can be installed in a face mask to allow the wearer to clearly and privately communicate with another user over a Bluetooth enabled mobile device such as a cell phone. In illustrated examples, a microphone unit is deformable to enable the microphone unit to form a custom fit over the nose bridge to seal the mask on the user's face. The face mask communication system includes an application program operating on the mobile device that allows a user to initiate and secure private conversations with other users.

Abstract: Method for identifying a subset of cells from a dataset for targeted gene expression analysis, comprising: defining an expected total recovered cell count for a barcode dataset; determining a region of interest for the total recovered cell count by calculating a lower bound for the region; and (b) calculating an upper bound for the region of interest by including an additional subset of barcodes having molecule counts below the lower bound; fitting the barcode dataset to a model; wherein the model groups barcodes as a function of molecule count; identifying a cut-off value on the model, wherein all barcodes having a molecule count above the cut-off value are called as cells; and identifying a targeted subset of cells from the called cells for conducting targeted gene expression, wherein a cell qualifies as part of the targeted subset if the cell has a molecule count above a target threshold.

Abstract: In one aspect, a method for filtering out erroneous sequence reads from a genomic sequence dataset, is disclosed. The genomic sequence dataset is received by one or more processors. The dataset is comprised of a plurality of fragment sequence reads, each with an associated barcode sequence and a unique identifier sequence. A threshold value for filtering out select fragment sequence reads from the genomic sequence dataset is determined by the one or more processors. The threshold value is a number of fragment sequence reads in the genomic sequence dataset with the same unique identifier sequence. Fragment sequence reads with the same unique identifier sequence occurring at less than the threshold value in the genomic sequence dataset is filtered out by the one or more processors. A filtered genomic sequence dataset is generated by the one or more processors.

Abstract: The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

Abstract: A system and method for a face mask communication system. The face mask communication system includes a removable microphone that can be installed in a face mask to allow the wearer to clearly and privately communicate with another user over a Bluetooth enabled mobile device such as a cell phone. In illustrated examples, a microphone unit is deformable to enable the microphone unit to form a custom fit over the nose bridge to seal the mask on the user's face. The face mask communication system includes an application program operating on the mobile device that allows a user to initiate and secure private conversations with other users.

Abstract: The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

Abstract: A data processing system for end-to-end configuration assistance for cloud services implements receiving a request from a client device for a solution assistant configured to provide step-by-step guidance for configuring a plurality of cloud services to interoperate to produce a specified result; causing to be presented a solution assistant user interface; providing the step-by-step guidance comprising a plurality of steps by: launching a configuration interface of a respective cloud service of the plurality of cloud services associated with a respective step of the plurality of steps; presenting step-by-step configuration information providing guidance for configuring the respective cloud service; and receiving a confirmation indication from the client device that the respective cloud service has been configured according to the step-by-step configuration information; generating a summary report that includes a summary of the cloud services configured using the solution assistant; and causing to be presented

Abstract: The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Abstract: The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.

Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.

Abstract: The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.