Patents by Inventor Joseph H. Mostmans

Joseph H. Mostmans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Acyl derivatives of azolones
    Patent number: 5637592
    Abstract: The invention is concerned with the compounds having the formula ##STR1## the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y is CH or N; R.sup.1, R.sup.2 and R.sup.3 each independently are hydrogen or C.sub.1-4 alkyl; R.sup.4 and R.sup.5 each independently are hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkyloxy, hydroxy, trifiuoromethyl, trifiuoromethyloxy or difluoromethyloxy; R.sup.6 is hydrogen; or R.sup.6 is phenyl optionally substituted with halo; pyridinyl; furanyl; thienyl; 3-chloro-benzo[b]thien-2-yl; trifiuoromethyl; C.sub.1-4 alkyloxycarbonyl; dihalophenylcyclopropanyl; C.sub.3-6 cycloalkyl; adamantyl; C.sub.2-6 alkenyl optionally substituted with halophenyl; or C.sub.1-4 alkyl optionally substituted with halo, phenyl, halophenyl, dihalophenyl, phenyloxy, piperidinyl, pyrrolidinyl, piperazinyl, C.sub.1-4 alkylpiperazinyl, C.sub.1-4 alkylcarbonylpiperazinyl, C.sub.1-4 alkyloxycarbonylpiperazinyl, phthalimino, amino, mono- or di(C.sub.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: June 10, 1997
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Raymond A. Stokbroekx, Joseph H. Mostmans, Louis J. E. Van der Veken
  • Sulfonamide derivatives of azolones
    Patent number: 5571811
    Abstract: The invention is concerned with the compounds having the formula ##STR1## the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y is CH or N; R.sup.1, R.sup.2 and R.sup.3 each independently are hydrogen or C.sub.1-4 alkyl; R.sup.4 and R.sup.5 each independently are hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R.sup.6 is C.sub.1-4 alkyl; or phenyl optionally substituted with halo, C.sub.1-4 alkylcarbonylamino, C.sub.1-4 alkyloxy, C.sub.1-4 alkyl or nitro; Z is C.dbd.O or CHOH; and ##STR2## is a radical of formula ##STR3## Compositions comprising said compounds, processes for preparing the same and the use of these compounds as a method of treating Helicobacter infection.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: November 5, 1996
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Raymond A. Stokbroekx, Joseph H. Mostmans, Louis J. E. Van der Veken
  • 4-[4- [4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-5-methyl-3H-1,2,4-triazol-3-o ne derivatives
    Patent number: 5254553
    Abstract: 2-[2-(4-chlorophenyl)-2-(hydroxy or oxo)ethyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-5-m ethyl-3H-1,2,4-triazol-3-one having the formula ##STR1## wherein X represents C=O or CHOH, for use as 5-lipoxygenase inhibitors. Pharmaceutical compositions, processes for preparing said compounds and compositions; and a method of treating leukotriene mediated diseases.
    Type: Grant
    Filed: August 24, 1992
    Date of Patent: October 19, 1993
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Joseph H. Mostmans, Johan R. M. Beetens
  • Heterocyclic derivatives of (4-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
    Patent number: 4533550
    Abstract: Novel heterocyclic derivatives of (4-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles, useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: August 27, 1981
    Date of Patent: August 6, 1985
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Joseph H. Mostmans
  • Antimicrobial imidazole derivatives
    Patent number: 4524110
    Abstract: The invention is concerned with novel dithioketal derivatives of 1-(2-aryl-2-oxoethyl)-1H-imidazoles and sulfones and sulfoxides derived therefrom, said compounds being useful as antimicrobial agents.
    Type: Grant
    Filed: September 28, 1984
    Date of Patent: June 18, 1985
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • Antimicrobial imidazole derivatives
    Patent number: 4483865
    Abstract: The invention is concerned with novel dithioketal derivatives of 1-(2-aryl-2-oxoethyl)-1H-imidazoles and sulfones and sulfoxides derived therefrom, said compounds being useful as antimicrobial agents.
    Type: Grant
    Filed: January 25, 1982
    Date of Patent: November 20, 1984
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • 1-(1,3-Dioxolan-2-ylmethyl)-1H-1,2,4-triazoles and compositions
    Patent number: 4358449
    Abstract: 1-(1,3,-Dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: February 15, 1980
    Date of Patent: November 9, 1982
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • 1-(1,3-Dioxolan-2-ylmethyl)-1H-imidazoles
    Patent number: 4335125
    Abstract: Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: June 15, 1982
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • Heterocyclic derivatives of (4-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
    Patent number: 4313953
    Abstract: Novel heterocyclic derivatives of (4-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles, useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: March 27, 1980
    Date of Patent: February 2, 1982
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Joseph H. Mostmans
  • Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles
    Patent number: 4268680
    Abstract: Novel intermediates for making heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles, useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: June 20, 1979
    Date of Patent: May 19, 1981
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-1,2,4-triazoles
    Patent number: 4244964
    Abstract: Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-1,2,4-triazoles useful as anti-fungal and anti-bacterial agents.
    Type: Grant
    Filed: June 20, 1979
    Date of Patent: January 13, 1981
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
    Patent number: 4232034
    Abstract: Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles useful as anti-fungal and anti-bacterial agents.
    Type: Grant
    Filed: June 20, 1979
    Date of Patent: November 4, 1980
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • Hydrazine carboxamide derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles
    Patent number: 4229581
    Abstract: Novel hydrazine carboxamide intermediates for making heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles, useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: June 20, 1979
    Date of Patent: October 21, 1980
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-1,2,4-triazoles having antifungal and antibacterial properties
    Patent number: 4229460
    Abstract: Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-1,2,4-triazoles useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: June 20, 1979
    Date of Patent: October 21, 1980
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • 1-(1,3-Dioxolan-2-ylmethyl)-1H-1,2,4-triazoles
    Patent number: 4223036
    Abstract: Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: September 16, 1980
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
    Patent number: 4218458
    Abstract: Novel heterocyclic derivatives of (4-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles, useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: March 14, 1979
    Date of Patent: August 19, 1980
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Joseph H. Mostmans
  • Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
    Patent number: 4160841
    Abstract: Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles, useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: November 21, 1977
    Date of Patent: July 10, 1979
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
    Patent number: 4144346
    Abstract: Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: November 21, 1977
    Date of Patent: March 13, 1979
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • 1-(.beta.-Aryl-.beta.-R-ethyl)imidazoles as antimicrobial agents
    Patent number: 3991201
    Abstract: Compounds of the class of 1-(.beta.-aryl-.beta.-R-ethyl)imidazoles, useful as antibacterial and antifungal agents.
    Type: Grant
    Filed: May 19, 1975
    Date of Patent: November 9, 1976
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans