Patents by Inventor Joseph Heitman

Joseph Heitman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fungicidal effect by regulating signal transduction pathways
    Publication number: 20060293381
    Abstract: The present invention concerns methods of treating fungal infections and methods of screening compounds for activity in treating fungal infections. Methods of the invention include using an active compound such as fludioxonil to treat a Cryptococcus neoformans infection. Also included are methods and pharmaceutical compositions useful for treating fungal infections using a Hog1 activator such as fludioxonil and a calcineurin inhibitor in combination.
    Type: Application
    Filed: June 22, 2006
    Publication date: December 28, 2006
    Inventors: Kaihei Kojima, Joseph Heitman, Yong-Sun Bahn
  • Combination therapies for fungal pathogens
    Publication number: 20060189551
    Abstract: The present invention relates to methods of treating fungal infections with a drug combination: a first compound that inhibits the activity or expression of the protein FKBP12 and a second compound that inhibits the activity or expression of homoserine dehydrogenase. Evidence indicates that dual inhibitors of proteins FKBP12 and homoserine dehydrogenase are lethal to fungi. Such an approach should be minimally toxic since this combination therapy targets a biosynthetic pathway that is conserved in fungi but not in mammals.
    Type: Application
    Filed: October 3, 2005
    Publication date: August 24, 2006
    Applicants: Duke University, Johns Hopkins University
    Inventors: Joseph Heitman, Miguel Arevalo-Rodriguez, Xuewen Pan, Jef Boeke