Patents by Inventor Joseph I. De Graw

Joseph I. De Graw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxoalkanoic acid derivatives as inhibitors of angiotensin converting enzyme
    Patent number: 4329473
    Abstract: This invention relates to novel analogs of proline terminal tripeptides and related compounds and is typified by ##STR1## The compounds are potent inhibitors of angiotensin converting enzyme and as such are useful as antihypertensive agents.
    Type: Grant
    Filed: December 24, 1980
    Date of Patent: May 11, 1982
    Inventors: Ronald G. Almquist, Joseph I. De Graw
  • N-Sec-alkyl analogs of norcodeine and normorphine and analgesic compositions and methods employing the normorphine derivatives
    Patent number: 4269843
    Abstract: Novel N-sec-alkyl derivatives of norcodeine and normorphine wherein the sec-alkyl group contains either four or five carbon atoms. Specifically included are those derivatives of norcodeine and normorphine wherein the sec-alkyl group is 2-butyl, 3-pentyl, .alpha.-methylallyl and .alpha.-methylcyclopropylmethyl. The normorphine derivatives having strong agonist potency combined with strong antagonist qualities and indicated low addiction potential. The norcodeine analogs are useful as intermediates in preparing the corresponding normorphine compounds.
    Type: Grant
    Filed: July 8, 1980
    Date of Patent: May 26, 1981
    Assignees: SRI International, The Board of Trustees of Leland Stanford Jr. University
    Inventors: Joseph I. De Graw, John A. Lawson, Howard L. Johnson, Gilda H. Loew
  • Folic acid derivatives and use in radio-assay
    Patent number: 4091087
    Abstract: Novel folic acid derivatives useful for radioassaying folic acid and its metabolites in biological liquids are prepared from pteroyl-.gamma.-glutamyl-tyrosines by iodination with I.sup.125 or I.sup.131.
    Type: Grant
    Filed: July 28, 1976
    Date of Patent: May 23, 1978
    Assignee: Smith Kline Instruments, Inc.
    Inventors: M. James Barrett, Joseph I. De Graw
  • Folic acid derivatives and use in radio-assay
    Patent number: 3989812
    Abstract: Novel folic acid derivatives useful for radio-assaying folic acid and its metabolites in biological liquids are prepared from pteroyl-.gamma.-glutamyl-tyrosines by iodination with I.sup.125 or I.sup.131.
    Type: Grant
    Filed: August 9, 1974
    Date of Patent: November 2, 1976
    Assignee: SmithKline Instruments, Inc.
    Inventors: M. James Barrett, Joseph I. De Graw