Patents by Inventor Joseph L. Mankowski

Joseph L. Mankowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DEEP LEARNING-BASED SEGMENTATION OF CORNEAL NERVE FIBER IMAGES
    Publication number: 20220215553
    Abstract: This disclosure relates to a method for automating segmentation of corneal nerve fibers based on a deep learning approach to segmentation. Methods of the invention offer more robust results by utilizing the power of supervised learning methods in concert with the pre- and post processing techniques documented.
    Type: Application
    Filed: May 18, 2020
    Publication date: July 7, 2022
    Applicants: Voxeleron, LLC, THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jonathan D. Oakley, Daniel B. Russakoff, Joseph L. Mankowski
  • Automated methods to count corneal subbasal nerves
    Patent number: 9757022
    Abstract: The present invention is directed to a software algorithm that measures the number of corneal nerve fibers in images captured by microscopy including images from patients obtained by in vivo corneal confocal microscopy, a noninvasive technique. The present invention solves a complicated segmentation problem, by exploiting the piece wise linear nature of the nerve fibers—i.e., the nerves are made up of a lot of straight line segments. The image is split into sub-regions, where each sub-region contains nerves mostly running in the same, straight direction. Having the nerves all in straight-lines within a single 2d image region dramatically simplifies the segmentation problem. The image intensities are summed in the direction of the nerves to reduce the 2d representation to a 1d signal having pronounced peaks where the nerves are located.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: September 12, 2017
    Assignees: THE JOHNS HOPKINS UNIVERSITY, VOXELERON, LLC
    Inventors: Joseph L. Mankowski, Jonathan D. Oakley, Daniel B. Russakoff
  • AUTOMATED METHODS TO COUNT CORNEAL SUBBASAL NERVES
    Publication number: 20160331225
    Abstract: The present invention is directed to a software algorithm that measures the number of corneal nerve fibers in images captured by microscopy including images from patients obtained by in vivo corneal confocal microscopy, a noninvasive technique. The present invention solves a complicated segmentation problem, by exploiting the piece wise linear nature of the nerve fibers—i.e., the nerves are made up of a lot of straight line segments. The image is split into sub-regions, where each sub-region contains nerves mostly running in the same, straight direction. Having the nerves all in straight-lines within a single 2d image region dramatically simplifies the segmentation problem. The image intensities are summed in the direction of the nerves to reduce the 2d representation to a 1d signal having pronounced peaks where the nerves are located.
    Type: Application
    Filed: May 12, 2016
    Publication date: November 17, 2016
    Inventors: Joseph L. Mankowski, Jonathan D. Oakley, Daniel B. Russakoff
  • Methods for Treating or Preventing Cardiac and Neurological Disorders Using Chemokine Receptor Antagonists
    Publication number: 20140057940
    Abstract: The invention provides methods for treating or preventing cardiac and neurological disorders using chemokine receptor antagonists.
    Type: Application
    Filed: January 11, 2012
    Publication date: February 27, 2014
    Inventors: Joseph L. Mankowski, David R. Graham