Patents by Inventor JOSEPH LARKIN
JOSEPH LARKIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11603387Abstract: The subject invention concerns peptide mimetics of SOCS proteins and methods of use. In one embodiment, a peptide mimetic of the invention binds to a SOCS1 and a SOCS3 target protein. In a specific embodiment, a peptide mimetic of the invention comprises the amino acid sequence of SEQ ID NO:1 and/or SEQ ID NO:2 and/or SEQ ID NO:51, or a functional fragment or variant thereof. In a further embodiment, a peptide of the invention can comprise multiple copies of the mimetic sequence. In one embodiment, a peptide of the invention comprises two or more copies of SEQ ID NO:1 and/or SEQ ID NO:2 and/or SEQ ID NO:51. In a specific embodiment, a peptide mimetic of the invention comprises the amino acid sequence of SEQ ID NO:3 and/or SEQ ID NO:4 to and/or SEQ ID NO:52, or a functional fragment or variant thereof. The subject invention also pertains to methods of treating and/or preventing autoimmune conditions and/or disorders.Type: GrantFiled: January 23, 2015Date of Patent: March 14, 2023Assignee: University of Florida Research Foundation, Inc.Inventors: Howard M. Johnson, Joseph Larkin, Chulbul M. Ahmed, Lindsey Jager
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Publication number: 20210302410Abstract: Described herein are devices containing freestanding, ultrathin (<10 nm thick) membranes and methods of making such devices. Also described are methods of using devices containing freestanding ultrathin membranes for determining the sequence of a polynucleotide and for desalination of aqueous solutions.Type: ApplicationFiled: June 10, 2021Publication date: September 30, 2021Inventors: Pradeep WADUGE, Joseph LARKIN, Moneesh UPMANYU, Swastik KAR, Meni WANUNU
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Patent number: 11041247Abstract: The invention provides methods for direct growth of low noise, atomically thin freestanding membranes of two-dimensional monocrystalline or polycrystalline materials, such as transition metal chalcogenides including molybdenum disulfide. The freestanding membranes are directly grown over an aperture by reacting two precursors in a chemical vapor deposition process carried out at atmospheric pressure. Membrane growth is preferentially over apertures in a thin sheet of solid state material. The resulting membranes are one or a few atomic layers thick and essentially free of defects. The membranes are useful for sequencing of biopolymers through nanopores.Type: GrantFiled: February 4, 2020Date of Patent: June 22, 2021Assignee: Northeastern UniversityInventors: Pradeep Waduge, Swastik Kar, Meni Wanunu, Joseph Larkin, Ismail Bilgin
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Patent number: 10811144Abstract: Examples of a system for generating and compressing magnetized plasma are disclosed. The system comprises a plasma generator with a first closed end and an outlet, and a flux conserving chamber that is in tight fluid communication with the outlet of the plasma generator such that the generated plasma is injected into an inner cavity of the flux conserving chamber. An elongated central axial shaft is also provided such that the central shaft extends through the outlet of the plasma generator into the flux conserver. The end of the central shaft in connected to the flux conserver. A power source that comprises a formation power circuit and a shaft power circuit is provided to provide a formation power pulse to the plasma generator to generate magnetized plasma, and a shaft power pulse to the central axial shaft to generate a toroidal magnetic field into the plasma generator and the flux conserving chamber.Type: GrantFiled: November 6, 2017Date of Patent: October 20, 2020Assignee: General Fusion Inc.Inventors: Michel Georges Laberge, Meritt Wayne Reynolds, Alexander Douglas Mossman, Stephen James Howard, Blake Kenton Rablah, Peter Joseph Larkin O'Shea, Donald James Froese, Charles Beaufort Eyrich
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Publication number: 20200173041Abstract: The invention provides methods for direct growth of low noise, atomically thin freestanding membranes of two-dimensional monocrystalline or polycrystalline materials, such as transition metal chalcogenides including molybdenum disulfide. The freestanding membranes are directly grown over an aperture by reacting two precursors in a chemical vapor deposition process carried out at atmospheric pressure. Membrane growth is preferentially over apertures in a thin sheet of solid state material. The resulting membranes are one or a few atomic layers thick and essentially free of defects. The membranes are useful for sequencing of biopolymers through nanopores.Type: ApplicationFiled: February 4, 2020Publication date: June 4, 2020Inventors: Pradeep WADUGE, Swastik KAR, Meni WANUNU, Joseph LARKIN, Ismail BILGIN
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Patent number: 10570444Abstract: Devices and methods useful for sequencing and characterizing single nucleic acid molecules involve large arrays of nanopore zero-mode waveguides (NZMWs). The methods and devices are made possible by fabrication of nanoporous membranes of appropriate porosity for use in nucleotide sequencing. The fabrication methods eliminate the need for serial nanopore formation and make possible the mass production of highly efficient DNA and RNA single molecule sequencing devices.Type: GrantFiled: May 11, 2016Date of Patent: February 25, 2020Assignee: Northeastern UniversityInventors: Meni Wanunu, Joseph Larkin, Robert Henley
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Patent number: 10550487Abstract: The invention provides methods for direct growth of low noise, atomically thin freestanding membranes of two-dimensional monocrystalline or polycrystalline materials, such as transition metal chalcogenides including molybdenum disulfide. The freestanding membranes are directly grown over an aperture by reacting two precursors in a chemical vapor deposition process carried out at atmospheric pressure. Membrane growth is preferentially over apertures in a thin sheet of solid state material. The resulting membranes are one or a few atomic layers thick and essentially free of defects. The membranes are useful for sequencing of biopolymers through nanopores.Type: GrantFiled: November 25, 2015Date of Patent: February 4, 2020Assignee: Northeastern UniversityInventors: Pradeep Waduge, Swastik Kar, Meni Wanunu, Joseph Larkin, Ismail Bilgin
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Publication number: 20190139650Abstract: Examples of a system for generating and compressing magnetized plasma are disclosed. The system comprises a plasma generator with a first closed end and an outlet, and a flux conserving chamber that is in tight fluid communication with the outlet of the plasma generator such that the generated plasma is injected into an inner cavity of the flux conserving chamber. An elongated central axial shaft is also provided such that the central shaft extends through the outlet of the plasma generator into the flux conserver. The end of the central shaft in connected to the flux conserver. A power source that comprises a formation power circuit and a shaft power circuit is provided to provide a formation power pulse to the plasma generator to generate magnetized plasma, and a shaft power pulse to the central axial shaft to generate a toroidal magnetic field into the plasma generator and the flux conserving chamber.Type: ApplicationFiled: November 6, 2017Publication date: May 9, 2019Inventors: Michel Georges Laberge, Meritt Wayne Reynolds, Alexander Douglas Mossman, Stephen James Howard, Blake Kenton Rablah, Peter Joseph Larkin O'Shea, Donald James Froese, Charles Beaufort Eyrich
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Patent number: 10047392Abstract: Described herein are systems for analysis of biopolymers and complexes containing biopolymers based on optical measurement of ion flux through pores. Also described are methods of using such devices for analysis of biopolymers and complexes containing biopolymers, including methods of determining the nucleotide sequences of polynucleotides.Type: GrantFiled: February 23, 2015Date of Patent: August 14, 2018Assignee: Northeastern UniversityInventors: Andrey Ivankin, Joseph Larkin, Robert Henley, Meni Wanunu
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Publication number: 20180135118Abstract: Devices and methods useful for sequencing and characterizing single nucleic acid molecules involve large arrays of nanopore zero-mode waveguides (NZMWs). The methods and devices are made possible by fabrication of nanoporous membranes of appropriate porosity for use in nucleotide sequencing. The fabrication methods eliminate the need for serial nanopore formation and make possible the mass production of highly efficient DNA and RNA single molecule sequencing devices.Type: ApplicationFiled: May 11, 2016Publication date: May 17, 2018Inventors: Meni WANUNU, Joseph LARKIN, Robert HENLEY
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Publication number: 20180038001Abstract: The invention provides methods for direct growth of low noise, atomically thin freestanding membranes of two-dimensional monocrystalline or polycrystalline materials, such as transition metal chalcogenides including molybdenum disulfide. The freestanding membranes are directly grown over an aperture by reacting two precursors in a chemical vapor deposition process carried out at atmospheric pressure. Membrane growth is preferentially over apertures in a thin sheet of solid state material. The resulting membranes are one or a few atomic layers thick and essentially free of defects. The membranes are useful for sequencing of biopolymers through nanopores.Type: ApplicationFiled: November 25, 2015Publication date: February 8, 2018Inventors: Pradeep WADUGE, Swastik KAR, Meni WANUNU, Joseph LARKIN, Ismail BILGIN
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Patent number: 9700609Abstract: The invention provides compositions for treating or preventing T1D (T1D), the compositions comprising one or more antigen presenting cells (APC) that have been pulsed with one or more bacteria and/or components of the bacteria, wherein the bacteria or their components confer upon the APCs the ability to inhibit the generation of diabetes-promoting T cells. The subject invention also provides a method of treating or preventing T1D in a subject, the method comprising administering APC that have been pulsed with one or more bacteria and/or components of the bacteria and wherein the bacteria or their components confer upon the APCs the ability to inhibit the generation of diabetes-promoting T cells.Type: GrantFiled: March 18, 2014Date of Patent: July 11, 2017Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATEDInventors: Joseph Larkin, Mark A. Atkinson
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Publication number: 20170058336Abstract: Described herein are systems for analysis of biopolymers and complexes containing biopolymers based on optical measurement of ion flux through pores. Also described are methods of using such devices for analysis of biopolymers and complexes containing biopolymers, including methods of determining the nucleotide sequences of polynucleotides.Type: ApplicationFiled: February 23, 2015Publication date: March 2, 2017Inventors: Audrey IVANKIN, Joseph LARKIN, Robert HENLEY, Meni WANUNU
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Publication number: 20170008929Abstract: The subject invention concerns peptide mimetics of SOCS proteins and methods of use. In one embodiment, a peptide mimetic of the invention binds to a SOCS1 and a SOCS3 target protein. In a specific embodiment, a peptide mimetic of the invention comprises the amino acid sequence of SEQ ID NO:1 and/or SEQ ID NO:2 and/or SEQ ID NO:51, or a functional fragment or variant thereof. In a further embodiment, a peptide of the invention can comprise multiple copies of the mimetic sequence. In one embodiment, a peptide of the invention comprises two or more copies of SEQ ID NO:1 and/or SEQ ID NO:2 and/or SEQ ID NO:51. In a specific embodiment, a peptide mimetic of the invention comprises the amino acid sequence of SEQ ID NO:3 and/or SEQ ID NO:4 to and/or SEQ ID NO:52, or a functional fragment or variant thereof. The subject invention also pertains to methods of treating and/or preventing autoimmune conditions and/or disorders.Type: ApplicationFiled: January 23, 2015Publication date: January 12, 2017Inventors: HOWARD M. JOHNSON, JOSEPH LARKIN, CHULBUL M. AHMED, LINDSEY JAGER
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Publication number: 20160282326Abstract: Devices contain freestanding, ultra thin (<10 nm thick) membranes and methods of making such devices. Methods of using devices contain freestanding ultra thin membranes for determining the sequence of a polynucleotide and for desalination of aqueous solutions. A device containing: a substrate having an upper surface, a lower surface, and an aperture, the aperture having one or more walls connecting the upper and lower surfaces and forming a well; and a membrane attached to the lower surface of the substrate and forming a floor of the well, the membrane having a thickness of less than 10 nm. The electrical conductance across the membrane is less than 1 nS/?m2.Type: ApplicationFiled: November 25, 2014Publication date: September 29, 2016Inventors: Pradeep Waduge, Joseph Larkin, Moneesh Upmanyu, Swastik Kar, Meni Wanunu
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Publication number: 20160022793Abstract: The invention provides compositions for treating or preventing T1D (T1D), the compositions comprising one or more antigen presenting cells (APC) that have been pulsed with one or more bacteria and/or components of the bacteria, wherein the bacteria or their components confer upon the APCs the ability to inhibit the generation of diabetes-promoting T cells. The subject invention also provides a method of treating or preventing T1D in a subject, the method comprising administering APC that have been pulsed with one or more bacteria and/or components of the bacteria and wherein the bacteria or their components confer upon the APCs the ability to inhibit the generation of diabetes-promoting T cells.Type: ApplicationFiled: March 18, 2014Publication date: January 28, 2016Inventors: Joseph LARKIN, Mark A. ATKINSON
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Publication number: 20140271718Abstract: The subject invention provides compositions for alleviating type 1 diabetes (T1D). In preferred embodiments, the compositions comprise an effective amount of one or more antigen presenting cells (APCs) that have been pulsed with one or more bacterial isolates and/or compounds from the isolates. The bacteria used to pulse the APCs are, preferably, those that confer upon the APCs the ability to inhibit the generation of diabetes-promoting T cells. In specific embodiments, these bacteria may be, for example, Eubacteria or Clostridia. In a preferred embodiment, the APCs are dendritic cells (DCs).Type: ApplicationFiled: March 17, 2014Publication date: September 18, 2014Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INCORPORATEDInventors: JOSEPH LARKIN, MARK A. ATKINSON
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Patent number: 8473119Abstract: For a vehicle having thrusters and control surfaces or other types of effectors having different cost of use and/or effectiveness as a function of vehicle speed, errors in position relative to an asserted control command are apportioned between errors of translational rate and pointing error as a function of speed in the vertical and/or horizontal planes and guidance commands are adjusted accordingly to produce commands that provide an optimal attitude for guidance of the vehicle through an arbitrary maneuver. The commands thus generated are then preferably apportioned between various available effectors to execute the maneuver most efficiently.Type: GrantFiled: September 15, 2008Date of Patent: June 25, 2013Assignee: Lockheed Martin CorporationInventors: Louis Joseph Larkin, Eugene Angelo Petrino
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Publication number: 20100070105Abstract: For a vehicle having thrusters and control surfaces or other types of effectors having different cost of use and/or effectiveness as a function of vehicle speed, errors in position relative to an asserted control command are apportioned between errors of translational rate and pointing error as a function of speed in the vertical and/or horizontal planes and guidance commands are adjusted accordingly to produce commands that provide an optimal attitude for guidance of the vehicle through an arbitrary maneuver. The commands thus generated are then preferably apportioned between various available effectors to execute the maneuver most efficiently.Type: ApplicationFiled: September 15, 2008Publication date: March 18, 2010Inventors: Louis Joseph Larkin, Eugene Angelo Petrino
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Patent number: 7019307Abstract: In detectors for imaging and other applications, delay line anodes are arrayed so as to allow detection of the location and/or timing of particle hits. The anodes are arrayed to provide an upper anode and one or more lower anodes, with particles incident on the upper anode passing in turn to the lower anodes. The anode arrays allow the use of identically manufactured anodes which are maintained in parallel spaced relation along the travel path of the particles of interest without dielectric material or other structure situated between the anodes. The spacing between the anodes is preferably adjustable so as to allow the installer and/or user to modify the performance characteristics of the array. The anodes may be made of pre-formed metal foil signal and ground layers laminated onto opposing sides of a dielectric sheet, or may be etched or otherwise formed from flex circuit material, so that the anodes and the overall array are light weight, compact, and flexible.Type: GrantFiled: June 25, 2001Date of Patent: March 28, 2006Assignee: Imago Scientific Instruments CorporationInventors: Tye Travis Gribb, John Joseph Larkin