Patents by Inventor Joseph Manetta

Joseph Manetta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-Ghrelin Antibodies
    Publication number: 20070237775
    Abstract: Monoclonal antibodies, including chimeric and humanized antibodies, that bind both acylated and unacylated human ghrelin are disclosed. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Such antibodies and antigen-binding portions thereof are useful for neutralizing ghrelin activity in, for example, a human subject suffering from a disorder in which ghrelin activity is detrimental.
    Type: Application
    Filed: July 6, 2005
    Publication date: October 11, 2007
    Applicant: Eli Lilly and Company
    Inventors: Kristine Kikly, Joseph Manetta, Derrick Witcher
  • Anti-ghrelin antibodies
    Publication number: 20060233788
    Abstract: Monoclonal antibodies, including humanized and chimeric antibodies, that bind acylated and unacylated human ghrelin are provided. Such monoclonal antibodies can be full-length, or an antigen-binding portion thereof, and are useful for neutralizing ghrelin activity, e.g., in a human subject suffering from a disorder in which ghrelin activity is detrimental.
    Type: Application
    Filed: September 2, 2004
    Publication date: October 19, 2006
    Inventors: Mark Heiman, Kristine Kikly, Joseph Manetta, Derrick Witcher
  • Purification and refolding of recombinant proteins
    Patent number: 4923967
    Abstract: The present invention discloses a new method for solubilizing and refolding recombinant proteins expressed as granules. The method involves sulfitolysis and the formation of a precipitate of protein-S-sulfonate by warming. The precipitate has been found to contain protein in high purity. In addition, proper folding takes place if the desired protein is fully reduced and passed through an intermediate concentration of denaturant which allows for a transition between its folded and unfolded states.
    Type: Grant
    Filed: September 26, 1988
    Date of Patent: May 8, 1990
    Assignee: Eli Lilly and Company
    Inventors: Jesse L. Bobbitt, Joseph Manetta