Abstract: The disclosure provides novel methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making modified nucleic acid donor templates for highly efficient and precise gene editing.

Abstract: The disclosure provides novel methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making modified nucleic acid donor templates for highly efficient and precise gene editing.

Abstract: A medical device with a capacitive sensing function includes a medical body having a syringe and a sensing circuit having an electrode, a protective film adhered to the medical body and including a plastic film, an electrode provided on the plastic film and opposite from the electrode of the medical body, and a capacitive sensor formed by the electrode of the medical body and the electrode of the protective film and being a part of the sensing circuit, wherein a capacitance value of the capacitive sensor changed under the condition of removing the protective film from the medical body, the sensing circuit being configured to detect the capacitance value and trigger corresponding function of the medical body.

Abstract: A medical device with a capacitive sensing function includes a medical body having a syringe and a sensing circuit having an electrode, a protective film adhered to the medical body and including a plastic film, an electrode provided on the plastic film and opposite from the electrode of the medical body, and a capacitive sensor formed by the electrode of the medical body and the electrode of the protective film and being a part of the sensing circuit, wherein a capacitance value of the capacitive sensor changed under the condition of removing the protective film from the medical body, the sensing circuit being configured to detect the capacitance value and trigger corresponding function of the medical body.

Abstract: Devices and systems which control the flow of fluid through a conduit are described herein. One flow control device that controls the flow of fluid through a conduit, includes a body having an axis and defining a passage that allows fluid to flow from an upstream position to a downstream position, the valve body having a converging portion in the upstream position with an inner surface that curves gradually inward, but having an annular rim formed by a portion that extends outward from the inward curving shape, and a throat between the converging and diverging portions; and, a flow regulator supported within the body for controlling the flow of fluid through the conduit, the flow regulator having an annular seating surface configured to contact the annular rim of the body.

Abstract: Devices and systems for controls the flow of fluid through a conduit are described herein. One flow control device that controls the flow of fluid through a conduit, includes a body having an axis and defining a passage that allows fluid to flow from an upstream position to a downstream position, the valve body having a converging portion in the upstream position with an inner surface that curves gradually inward, but having an annular rim formed by a portion that extends outward from the inward curving shape, and a throat between the converging and diverging portions; and, a flow regulator supported within the body for controlling the flow of fluid through the conduit, the flow regulator having an annular seating surface configured to contact the annular rim of the body.