Patents by Inventor Joseph P.Y. Kao

Joseph P.Y. Kao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeted delivery of imaging probes for in vivo cellular imaging
    Patent number: 10202342
    Abstract: The present invention relates to nitroxide imaging probes that are isotopically modified or unmodified. Such nitroxide imaging probes may be included in liposomes that encapsulate self-quenching concentrations thereof, wherein the liposomes optionally comprise a targeting ligand specific to and having affinity for targeted tissue.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: February 12, 2019
    Assignee: University of Maryland, Baltimore
    Inventors: Joseph P. Y. Kao, Scott R. Burks, Gerald R. Rosen
  • TARGETED DELIVERY OF IMAGING PROBES FOR IN VIVO CELLULAR IMAGING
    Publication number: 20110165087
    Abstract: The present invention relates to nitroxide imaging probes that are isotopically modified or unmodified. Such nitroxide imaging probes may be included in liposomes that encapsulate self-quenching concentrations thereof, wherein the liposomes optionally comprise a targeting ligand specific to and having affinity for targeted tissue.
    Type: Application
    Filed: December 22, 2010
    Publication date: July 7, 2011
    Inventors: JOSEPH P.Y. KAO, SCOTT R. BURKS, GERALD R. ROSEN
  • USE OF 3-ALKANOYLOXYMETHOXYCARBONYL NITROXIDE ESTERS AS OXIMETRY PROBES FOR MEASUREMENT OF OXYGEN STATUS IN TISSUES
    Publication number: 20100260684
    Abstract: The present invention provides for lipophilic, labile alkanoyloxymethyl esters of nitroxides that cross the blood-brain barrier, and after hydrolysis with esterases therein, the corresponding anionic nitroxides are intracellularly entrapped at levels sufficient to permit O2 measurements by electron paramagnetic resonance spectroscopy.
    Type: Application
    Filed: June 2, 2008
    Publication date: October 14, 2010
    Inventors: Joseph P.Y. Kao, Gerard M. Rosen, Ke-Jian Liu
  • Caged amino acid derivatives bearing photolabile protective groups
    Patent number: 6310083
    Abstract: Derivatives of o-nitromandelyoxycarbonyl (Nmoc) which are capable of releasing an amino acid (or derivative thereof), upon irradiation with ultraviolet (UV) light are disclosed, as well as a method for producing a free amino acid (or derivative thereof) employing the same, e.g., to study neurophysiology.
    Type: Grant
    Filed: December 21, 1998
    Date of Patent: October 30, 2001
    Assignee: University of Maryland Boitechnology Institute
    Inventors: Joseph P.Y. Kao, Francis M. Rossi
  • Photosensitive organic compounds that release 2,5,-di(tert-butyl)hydroquinone upon illumination
    Patent number: 6043065
    Abstract: Derivatives of o-nitromandelyoxycarbonyl (Nmoc) which are capable of releasing 2,5,-di(tert-butyl)hydroquinone (DBHQ) upon irradiation with ultraviolet (UV) light, are disclosed, as well as, a method for producing DBHQ employing the same so as to allow rapid, reversible transient inhibition of sarcoplasmic/endoplasmic reticulum Ca.sup.2+ ATPases.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: March 28, 2000
    Assignee: University of Maryland Biotechnology Institute
    Inventors: Joseph P. Y. Kao, Francis M. Rossi, Paul F. Keitz
  • Photosensitive organic compounds that release carbon monoxide upon illumination
    Patent number: 5670664
    Abstract: The present invention relates to acetal derivatives of bicyclo?2.2.1!hepta-2,5-diene-7-one (norbornadienone) which are capable of releasing carbon monoxide upon irradiation with ultraviolet light, and a method for producing carbon monoxide employing the same.
    Type: Grant
    Filed: September 8, 1995
    Date of Patent: September 23, 1997
    Assignee: University Of Maryland Biotechnology Institute
    Inventors: Joseph P. Y. Kao, Paul F. Keitz
  • Workpiece holder and method for plasma reactor apparatus
    Patent number: 4222839
    Abstract: A holder and method for controlling and uniformly maintaining the temperature of work pieces when the work pieces are acted upon by a plasma in a plasma reactor apparatus. Support means which hold the work pieces so as to expose them to the reactive plasma also position metallic plate members which are capable of being heated to an elevated temperature by the plasma when in electrical contact with an electrode of the plasma reactor apparatus. The metallic plate members are all electrically shorted together, but are insulated from the support means. A temperature sensitive switch connects the metallic plate members to an electrode of the plasma apparatus. Work pieces to be acted upon by the plasma are placed in proximity to the metal plate members. In the presence of a plasma and when shorted to the apparatus electrode, the metallic plate members are rapidly heated and heat is conducted to the work pieces to heat them uniformly.
    Type: Grant
    Filed: September 21, 1978
    Date of Patent: September 16, 1980
    Assignee: Motorola, Inc.
    Inventors: Willis R. Goodner, Joseph P. Y. Kao