Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: A product dispenser with a reservoir for a product and a cap. The cap has a first assembly and a second assembly. The first assembly can include a button configured to dispense the product through a lower end orifice of the pipette, when the button is actuated. The second assembly can include a pipette rigidly connected and in fluidic communication with a chamber configured to change its volume depending on the movement of the first assembly relative to the second assembly and the movement of the button.

Abstract: A method is provided for collecting measurement parameters related to imbalance forces of a tire/hub assembly of a vehicle during motion of the vehicle. An apparatus is removably attached to the tire/hub assembly of the vehicle via lug nuts of the tire/hub assembly. The apparatus includes a disk, a plurality of cup-shaped objects, and one or more inertial measurement units (IMU's) mounted to the disk. Each of the cup-shaped objects are rigidly fixed at one end to the disk and extend perpendicularly outward from the disk. The plurality of cup-shaped objects are arranged a fixed radial distance from a radial center of the disk in a pattern that matches the lug nuts of the tire/hub assembly. The one or more inertial measurement units (IMU's) are mounted to the disk and configured to measure parameters that are used for calculating the imbalance forces during motion of the vehicle.

Abstract: Optical network systems and components are disclosed, including a transmitter comprising a digital signal processor that receives data; circuitry that generate a plurality of electrical signals based on the data; a plurality of filters, each of which receiving a corresponding one of the plurality of electrical signals, a plurality of roll-off factors being associated with a respective one of the plurality of filters; a plurality of DACs that receive outputs from the digital signal processor, the outputs being indicative of outputs from the plurality of filters; a laser that supplies light; and a modulator that receives the light and outputs from the DACs, and supplies a plurality of optical subcarriers based on the outputs, such that one of the optical subcarriers has a frequency bandwidth that is wider than remaining ones of the optical subcarriers, said one of the optical subcarriers carrying information for clock recovery.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: A method and system for obtaining an identifier from an item is disclosed. The method includes autonomously operating a robotic structure having a robotic arm to pick an item using an end effector of the robotic arm along a predetermined path from a source location to a destination location according to a plan. The picked item is moved according to the plan. An active measure is determined to be performed at least in part to obtain an identifier determined to be missing based on information received via the communication interface from one or more sensors. The robotic structure is autonomously operated to place the item at the destination location based at least in part on the plan.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the cellular entry of hepatitis B virus (HBV) and/or hepatitis D virus (HDV) or interfere with the function of the life cycle of HBV and/or HDV and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV and/or HDV infection. The invention also relates to methods of treating an HBV and/or HDV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: The present invention features crystalline forms of Compound I, including polymorphs and pseudopolymorphs, which are useful in the preparation of pharmaceutical compositions.

Abstract: A system including one or more processors and one or more non-transitory computer-readable media storing computing instructions that, when executed on the one or more processors, perform certain acts. The acts can include obtaining an original load design for loading a trailer to deliver stacks of pallets to physical stores. The load design specifies a respective floor spot assignment for each of the stacks. The original load design satisfies center-of-gravity constraints. The acts also can include generating fluid groups of the stacks to form an initial fluid grouping. The acts additionally can include determining that the fluid groups do not collectively satisfy the center-of-gravity constraints. The acts further can include until the fluid groups collectively satisfy the center-of-gravity constraints, repeatedly determining one or more infeasible groups from the fluid groups, and adjusting at least one of the one or more infeasible groups to update the fluid groups.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: An end effector is disclosed. The end effector includes a first set of one or more suction cups of a first size having a first diameter, and a second set of one or more suction cups of a second size having a second diameter that is smaller than the first diameter. The end effector further includes a first actuation mechanism configured to apply suction to at least a subset of the first set of suction cups independently of actuation of the second set of suction cups and a second actuation mechanism configured to apply suction to at least a subset of the second set of suction cups independently of actuation of the first set of suction cups.

Abstract: Techniques for determining a vehicle trajectory that causes a vehicle to navigate in an environment relative to one or more objects are described herein. For example, the techniques may include a computing device determining a decision tree having nodes to represent different object intents and/or nodes to represent vehicle actions at a future time. A tree search algorithm can search the decision tree to evaluate potential interactions between the vehicle and the one or more objects over a time period, and output a vehicle trajectory for the vehicle. The vehicle trajectory can be sent to a vehicle computing device for consideration during vehicle planning, which may include simulation.

Abstract: A robotic system is disclosed. The robotic system includes (i) a robotic arm positioned in a known location adjacent to a work zone with respect to which the robotic arm is configured to manipulate one or more items, (ii) one or more sensors each positioned in a corresponding fixed location relative to the work zone, and (iii) one or more processors configured to configure the robotic system to use the robotic arm to manipulate the one or more items, the robotic system being configured based at least in part on sensor data, the sensor data comprising information indicative of a relative position of the robotic arm and one or more other objects in the work zone.

Abstract: Disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a homologous prime/boost vaccination strategy, such as adenoviral vectors for use in a homologous prime/boost vaccination strategy.

Abstract: Disclosed is a method of receiving and processing content-sending inputs received by a head-worn device system including one or more display devices, one or more cameras and a vertically-arranged touchpad. The method includes displaying a content item on the one or more display devices, receiving a touch input on the touchpad corresponding to a send instruction, displaying a carousel of potential recipients, receiving a horizontal touch input on the touchpad, scrolling the carousel left or right on the one or more display devices in response to the horizontal touch input, receiving a tap touch input on the touchpad to select a particular recipient, receiving a further touch input, and in response to the further touch input, transmitting the content item to the selected recipient.

Abstract: A dual-fuel turbine engine is a type of turbine engine that can operate using two different fuel sources, such as liquid fuel (e.g., diesel) and natural gas. For liquid fuels, the turbine engine includes a primary line to facilitate engine startup and a secondary line to modify power output. Generally, the turbine engine only uses one type of fuel for combustion at a time. The fuel lines and passages in the fuel nozzles that carry the unused fuel source should preferably be purged and sealed by a purging system to reduce coking. However, conventional purge systems typically purge and seal only the secondary line for liquid fuels. As a result, the passages in the fuel nozzles connected to the primary line are prone to coking. To address this problem, a purge system is disclosed that purges and seals the primary line and, optionally, the secondary line.

Abstract: A melt-blown fabric for pouching smokeless tobacco or a smokeless tobacco substitute can include melt-blown polymer fibers. The fabric can have a basis weight of less than 30 gsm and a tensile strength of at least 4mJ in at least one predetermined direction. Method of making the fabric can include melt-blowing a polymeric material against a support surface and bonding the fibers or arranging them in a predetermined orientation. Pouched smokeless tobacco or tobacco substitute products including the fabrics provided herein can provide desirable flavor and tactile experience.

Abstract: The invention provides isoform-selective anti-TGF? antibodies and methods of using the same. In particular, isoform-selective anti-TGF?2, anti-TGF?3, and anti-TGF?2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGF?-related disorders.

Abstract: An example apparatus to prevent side load in hydraulic override pumps includes a lever rotatably mounted to a support. The apparatus includes a pump cylinder rotatable about a first end of the pump cylinder. The apparatus also includes a pump rod operatively coupled to the lever to move within the pump cylinder based on rotation of the lever. The pump cylinder rotates when the pump rod moves within the pump cylinder.

Abstract: Manual hydraulic override pumps for use with actuators are described herein. An example apparatus includes a manifold including a reservoir port to be fluidly coupled to a reservoir of fluid, a pump port to be fluidly coupled to a pump, a first actuator port to be fluidly coupled to a first chamber of an actuator, and a second actuator port to be fluidly coupled to a second chamber of the actuator. The example apparatus also includes a rotor disposed in a cavity formed in the manifold. The rotor is rotatable between a first actuating position in which the rotor fluidly couples the first actuator port and the pump port, and a second actuating position in which the rotor fluidly couples the second actuator port and the pump port.