Patents by Inventor Joseph Swistok

Joseph Swistok has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glucose-dependent insulinotropic peptide analogs
    Patent number: 9023986
    Abstract: The present invention provides compounds which are analogs of glucose-dependent insulinotropic polypeptide (GIP) and pharmaceutically acceptable salts of such compounds. These compounds have activity as agonists of GIP receptor.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: May 5, 2015
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Waleed Danho, George Ehrlich, Wajiha Khan, Joseph Swistok, Jefferson Wright Tilley
  • Neuropeptide-2 receptor (Y-2R) agonists
    Patent number: 8299023
    Abstract: Provided herein are neuropeptide-2 receptor agonists of the formula (I): Y—R1—R2—X—R3—R4—R5—R6—R7—R8—R9—R10—R11—R12—R13—R14—NH2??(I) (SEQ ID NO: 1), as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: October 30, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Waleed Danho, David Charles Fry, Robert Alan Goodnow, Jr., Wajiha Khan, Joseph Swistok, Jefferson Wright Tilley
  • Neuropeptide-2 receptor (Y-2R) agonists and uses thereof
    Patent number: 8268784
    Abstract: Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. X is 4-oxo-6-(1-piperazinyl)-3(4H)-quinazoline-acetic acid (Pqa). These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: September 18, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Karin Conde-Knape, Waleed Danho, George Ehrlich, Nader Fotouhi, David Charles Fry, Wajiha Khan, Anish Konkar, Cristina Martha Rondinone, Joseph Swistok, Rebecca Anne Taub, Jefferson Wright Tilley
  • GLUCOSE-DEPENDENT INSULINOTROPIC PEPTIDE ANALOGS
    Publication number: 20120101037
    Abstract: The present invention provides compounds which are analogs of glucose-dependent insulinotropic polypeptide (GIP) and pharmaceutically acceptable salts of such compounds. These compounds have activity as agonists of GIP receptor.
    Type: Application
    Filed: October 17, 2011
    Publication date: April 26, 2012
    Inventors: Waleed Danho, George Ehrlich, Wajiha Khan, Joseph Swistok, Jefferson Wright Tilley
  • NEUROPEPTIDE-2 RECEPTOR (Y-2R) AGONISTS
    Publication number: 20110172147
    Abstract: Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
    Type: Application
    Filed: March 25, 2011
    Publication date: July 14, 2011
    Inventors: Karin Conde-Knape, Waleed Danho, Nader Fotouhi, David Charles Fry, Wajiha Khan, Anish Konkar, Cristina Martha Rondinone, Joseph Swistok, Jefferson Wright Tilley
  • Neoropeptide-2-Receptor (Y-2R) Agonists
    Publication number: 20100179093
    Abstract: Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
    Type: Application
    Filed: November 2, 2009
    Publication date: July 15, 2010
    Inventors: Waleed Danho, Nader Fotouhi, David Charles Fry, Wajiha Khan, Joseph Swistok, Jefferson Wright Tilley
  • NEUROPEPTIDE-2 RECEPTOR (Y-2R) AGONISTS AND USES THEREOF
    Publication number: 20100137223
    Abstract: Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. X is 4-oxo-6-(1-piperazinyl)-3(4H)-quinazoline-acetic acid (Pqa). These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
    Type: Application
    Filed: August 6, 2009
    Publication date: June 3, 2010
    Inventors: Karin Conde-Knape, Waleed Danho, George Ehrlich, Nader Fotouhi, David Charles Fry, Wajiha Khan, Anish Konkar, Cristina Martha Rondinone, Joseph Swistok, Rebecca Anne Taub, Jefferson Wright Tilley
  • NEUROPEPTIDE-2 RECEPTOR (Y-2R) AGONISTS
    Publication number: 20100069307
    Abstract: Provided herein are neuropeptide-2 receptor agonists of the formula (I): Y—R1—R2—X—R3—R4—R5—R6—R7—R8—R9—R10—R11—R12—R13—R14—NH2 ??(I), as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
    Type: Application
    Filed: August 25, 2009
    Publication date: March 18, 2010
    Inventors: Waleed Danho, David Charles Fry, Robert Alan Goodnow, JR., Wajiha Khan, Joseph Swistok, Jefferson Wright Tilley
  • Neuropeptide-2 receptor (Y-2R) agonists and uses thereof
    Patent number: 7642244
    Abstract: Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. X is 4-oxo-6-(1-piperazinyl)-3(4H)-quinazoline-acetic acid (Pqa). These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: January 5, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Karin Conde-Knape, Waleed Danho, George Ehrlich, Nader Fotouhi, David Charles Fry, Wajiha Khan, Anish Konkar, Cristina Martha Rondinone, Joseph Swistok, Rebecca Anne Taub, Jefferson Wright Tilley
  • N-Methylation of amino acids
    Publication number: 20090264620
    Abstract: The present invention is directed to a method for ?N-methylation of amino acids suitable for on-resin methylation, compatible with Fmoc/tBu SPPS, and compatible with amino acids bearing protected or unprotected nucleophilic side-chains, notably Arg(Pbf), Met, Cys, and Trp. The present invention is further directed to a compound of Formula I wherein m, n, X and Y are defined as described herein.
    Type: Application
    Filed: April 17, 2009
    Publication date: October 22, 2009
    Inventors: Jason A. Moss, Joseph Swistok
  • Neuropeptide-2 receptor (Y-2R) agonists and uses thereof
    Patent number: 7410949
    Abstract: Provided herein are neuropeptide-2 receptor agonists of the formula (I): Y—R1—R2—X—R3—R4—R5—R6—R7—R8—R9—R10—R11—R12—R13—R14—NH2, ??(I) as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: August 12, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Waleed Danho, George Ehrlich, David C Fry, Wajiha Khan, Joseph Swistok
  • Selective Linear Peptides with Melanocortin-4 Receptor (MC4-R) Agonist Activity
    Publication number: 20080177036
    Abstract: Peptides of formulae I, II and III that selectively activate melanocortin-4 (MC-4) receptor activity.
    Type: Application
    Filed: March 14, 2008
    Publication date: July 24, 2008
    Inventors: Li Chen, Adrian Wai-Hing Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Keith Alan Yagaloff
  • Neuropeptide-2 receptor (Y-2R) agonists and uses thereof
    Publication number: 20070135351
    Abstract: Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
    Type: Application
    Filed: December 1, 2006
    Publication date: June 14, 2007
    Inventors: Karin Conde-Knape, Waleed Danho, George Ehrlich, Nader Fotouhi, David Fry, Wajiha Khan, Anish Konkar, Cristina Rondinone, Joseph Swistok, Rebecca Taub, Jefferson Tilley
  • Neuropeptide-2 receptor (Y-2R) agonists and uses thereof
    Publication number: 20060160742
    Abstract: Provided herein are neuropeptide-2 receptor agonists of the formula (I): Y—R1—R2—X—R3—R4—R5—R6—R7—R8—R9—R10—R11—R12—R13—R14—NH2??(I), as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.
    Type: Application
    Filed: January 10, 2006
    Publication date: July 20, 2006
    Inventors: Waleed Danho, George Ehrlich, David Fry, Wajiha Khan, Joseph Swistok
  • Selective cyclic peptides with melanocortin-4 receptor (MC4-R) agonist activity
    Patent number: 7045591
    Abstract: Peptides cyclized via disulfide or lactam bridges are disclosed. The peptides exhibit melanocortin-4 receptor agonist activity and are useful for treating obesity.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: May 16, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Adrian Wai-Hing Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Yao Wang, Keith Alan Yagaloff
  • Selective linear peptides with melanocortin-4 receptor (MC4-R) agonist activity
    Publication number: 20050239711
    Abstract: Peptides of formulae I, II and III that selectively activate melanocortin-4 (MC-4) receptor activity.
    Type: Application
    Filed: June 22, 2005
    Publication date: October 27, 2005
    Inventors: Li Chen, Adrian Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Keith Yagaloff
  • Selective linear peptides with melanocor tin-4 receptor (MC4-R) agonist activity
    Publication number: 20030229200
    Abstract: Peptides of formulae I, II and III that selectively activate melanocortin-4 (MC-4) receptor activity.
    Type: Application
    Filed: May 9, 2003
    Publication date: December 11, 2003
    Inventors: Li Chen, Adrian Wai-Hing Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Keith Alan Yagaloff
  • Selective linear peptides with melanocortin-4 receptor (MC4-R) agonist activity
    Patent number: 6600015
    Abstract: Peptides that selectively stimulate melanocortin-4 (MC-4) receptor activity are disclosed.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: July 29, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Adrian Wai-Hing Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Keith Alan Yagaloff
  • Selective cyclic peptides with melanocortin-4 receptor (MC4-R) agonist activity
    Publication number: 20020143141
    Abstract: Peptides cyclized via disulfide or lactam bridges having melanocortin-4 receptor (MC4-R) agonist activity useful for treatment of obesity.
    Type: Application
    Filed: August 27, 2001
    Publication date: October 3, 2002
    Inventors: Li Chen, Adrian Wai-Hing Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Yao Wang, Keith Alan Yagaloff
  • Selective linear peptides with melanocortin-4 receptor (MC4-R) agonist activity
    Publication number: 20010056179
    Abstract: Peptides of formulae I, II and III selectively activate melanocortin-4 (MC-4) receptor activity.
    Type: Application
    Filed: March 19, 2001
    Publication date: December 27, 2001
    Inventors: Li Chen, Adrian W. Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Keith A. Yagaloff