Abstract: A modified novel process for preparing cyclopropylamine from .gamma.-butyrolactone is described. The .gamma.-butyrolactone ring is cleaved with a hydrohalide in the presence of a novel catalyst comprising an aqueous sulfuric acid solution. The 4-chlorobutyric acid, thus formed is converted into a hindered chlorobutyrate ester. The hindered ester based on secondary and tertiary alkanols of eight or less carbon atoms, is cyclized to form the hindered cyclopropanecarboxylate ester by a novel reaction medium consisting of solid caustic in a water-immiscible solvent and a phase transfer catalyst. The hindered cyclopropanecarboxylate ester is ammoniated to form cyclopropanecarboxamide by a novel catalyst comprising an alkali metal salt of a polyol having hydroxy groups on adjacent carbons. The carboxamide formed in substantially quantitative yields is converted to cyclopropylamine by a modified Hofmann reaction utilizing continuous degradation of the intermediate with simultaneous distillation.

Abstract: A process is described for the production of 2-isopropyl-4-methyl-6-hydroxypyrimidine (oxypyrimidine) by reacting isopropylamidine in an alkaline lower alkanol solvent system with an alkyl acetoacetate to close the ring and form the oxypyrimidine in a continuous flow multi-stage reactor (MSR) under controlled multi-stage conditions whereby the reactants contact each other in each of said stages under conditions which reduce the possibility of the formation of unwanted reaction products from said reactants in said solvent system.

Abstract: A process is provided for the manufacture of methomyl oxime comprising the steps of chlorinating acetaldoxime dissolved in N-methylpyrrolidone at a temperature range of -10.degree. C. to 0.degree. C. to form a N-methylpyrrolidone solution of acethydroxamoyl chloride; thioesterifying the acethydroxyamoyl chloride in said solution at a temperature range of about 0.degree. C. to 10.degree. C. at pH in the range 6-7.

Abstract: A process for preparing 2,6-dialkylcyclohexylamine, e.g., 2,6-dimethylcyclohexylamine, from a corresponding dialkylphenol, e.g., 2,6-dimethylphenol, by passing the phenol over a bed of a hydrogen-transfer catalyst in the presence of ammonia at elevated temperatures and pressures.

Abstract: Production of 2-alkyl- or cycloalkyl-4-methyl-6-hydroxypyrimidines by first neutralizing an alkyl imidate ester hydrochloride with a base in the presence of a water-immiscible solvent for the alkyl imidate ester to be freed thereby; condensing the alkyl imidate ester with diketene to form an oxazinone intermediate, which is then reacted in organic solution with gaseous ammonia and recovering the desired substituted 6-hydroxypyrimidine.