Abstract: A data center may predict infrastructure failures in order to perform mitigation actions at services hosted at the data center. Operational metrics for different infrastructure systems of a data center may be collected and analyzed to generate failure models. The failure models may be evaluated to predict infrastructure failure events. The predicted infrastructure failure events may be programmatically provided to the services. The services may evaluate the prediction and select mitigation actions to perform. For data centers implemented as part of a provider network with services hosted across multiple data centers, mitigation actions may be performed at multiple data centers for a service in response to a predicted failure event at one data center.