Abstract: A composition for binding FKBP proteins is disclosed, along with a method of treating conditions associated with neuronal degeneration, wherein said composition comprises a compound of formula I, wherein, R, R1, R2, R3 and X are as defined herein.

Abstract: Methods for introducing a 1-halo-1-haloalkene compound onto an aromatic or heteroaromatic ring are provided, including processes for the production of certain 1-halovinyl aryl or heteroaryl derivatives in which the 1-halovinyl group is either 1-fluoro or 1-chlorovinyl and the aromatic species phenyl or thiophene, the processes including coupling an arylmagnesium species with a dihalo olefin in the presence of a nickel or iron catalyst.

Abstract: An apparatus is disclosed for use in solid-phase chemical synthesis procedures. The apparatus allows the separation of a cleaved product from the solid-phase used to make the product, and subsequent removal of the solid-phase from the apparatus. The apparatus allows the cleaved product to be concentrated within the apparatus without transfer to another device.

Abstract: Methods for introducing a 1-halo-1-haloalkene compound onto an aromatic or heteroaromatic ring are provided, including processes for the production of certain 1-halovinyl aryl or heteroaryl derivatives in which the 1-halovinyl group is either 1-fluoro or 1-chlorovinyl and the aromatic species phenyl or thiophene, the processes including coupling an arylmagnesium species with a dihalo olefin in the presence of a nickel or iron catalyst.

Abstract: A composition for binding FKBP proteins is disclosed, along with a method of treating conditions associated with neuronal degeneration, wherein said composition comprises a compound of formula I, wherein, R, R1, R2, R3 and X are as defined herein.

Abstract: An apparatus is disclosed for use in solid-phase chemical synthesis procedures. The apparatus allows the separation of a cleaved product from the solid-phase used to make the product, and subsequent removal of the solid-phase from the apparatus. The apparatus allows the cleaved product to be concentrated within the apparatus without transfer to another device.

Abstract: A control system for controlling a motor driving a separator roller of a collation-feeder stager assembly in an inserter system including one or more enclosure feeders, the collation-feeder stager assembly including a following roller assembly having a first and a second, following, set of rollers, the control system comprising: an edge sensor, disposed so as to have a line of sight suitable for sensing the arrival, between the first and second set of the following roller assembly, of a leading or trailing edge of a collation, and for providing signals indicating the arrival of the edge; and a controller, responsive to the signals indicating the arrival of the edge, for determining a motion control profile for the motor designed to maintain within a predetermined range a gap between collations based on having the controller decelerate the separator roller upon receiving a leading edge signal from the edge sensor.

Abstract: The preparation of 14-membered macrocycles from a resin-bound orthogonally protected lysine residue is described. Reductive alkylation of the a-nitrogen followed by acylation with an Fmoc-aminoacid provides a protected dipeptide precursor. Removal of the Fmoc-group, acylation with a succinic anhydride, methyltrityl-group removal and macrocyclization provides the desired macrocycles, after TFA cleavage, in excellent yield and purity.

Abstract: A method of collating unfolded sheets of paper into a collation and combining the collation with a folded sheet of paper. The method comprises: feeding a plurality of unfolded sheets of paper seriatim along a feed path from an upstream position to a downstream position; conveying the unfolded sheets seriatim around a drum to cause the unfolded sheets to be conveyed to an upstream position; stopping the unfolded sheets seriatim in a pocket having a back panel and a top panel, the back panel stopping the unfolded sheets from being conveyed further upstream and forming a collation of the unfolded sheets; feeding a folded document having a leading folded edge from an upstream to a downstream position across the top panel on top of the collation of unfolded sheets, thereby forming a single stack of documents; and conveying the single stack of documents to a downstream location.

Abstract: 1-[[(Dialkylamino)alkyl]amino]-4-substituted-thioxanthen-9-ones are disclosed as antitumor agents. Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.

Abstract: 1-[[(Dialkylamino)alkyl]amino]-4-substituted-thioxanthen-9-ones are disclosed as antitumor agents. Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.

Abstract: Apparatus for processing sheets, comprising: first structure for feeding a nestable sheet having a leading edge downstream in a path of travel; structure for forming a buckle loop in a foldable sheet, the buckle loop forming structure including a stop, the buckle loop forming structure including second structure for feeding the foldable sheet across the path of travel and against the stop to form a buckle loop therein, the buckle loop forming structure including structure for guiding the buckle loop downstream of the leading edge of the nestable sheet and in the path of travel thereof; and structure for assembling the sheets, the assembling structure including third structure for feeding the sheets in the path of travel, the third feeding structure including an elongate drive roller extending transverse to the path of travel, the third feeding structure including an elongate roller extending parallel to the drive roller and defining therebetween an elongate gap, and the assembling structure including structur

Abstract: Apparatus for aligning a document, the apparatus comprising: structure for feeding a document in a downstream path of travel, the document have a downstream edge relative to the path of travel; structure for registering the downstream edge of a document in a direction extending transverse to the path of travel, the registering structure including at least one member extending into the path of travel, the registering structure including structure for moving the at least one member downstream in the path of travel; and structure for controlling the feeding structure to urge a document into engagement with the at least one moving member.

Abstract: Macrocyclic oligomers, including polycarbonates, polyesters, polyamides, polyimides, polyetherketones and polyethersulfones, are conveniently prepared from various spiro(bis)indane compounds, especially the 6,6'-difunctional 3,3',3'-tetramethylspiro(bis)indanes. The macrocyclic oligomers may be conveniently converted to linear polymers.

Abstract: Cyclic polyphenylene ether-polycarbonate oligomer compositions are prepared from bishaloformates and bisphenols, at least one of which includes a spirobiindane moiety and the other of which is derived from a bisphenol-terminated polyphenylene ether oligomer. The cyclic compositions may be converted to linear copolycarbonates by treatment with a polycarbonate formation catalyst.

Abstract: Copolyamides are prepared by the reaction of monocyclic spiro(bis)indane polyamide oligomers with lactams in the presence of basic reagents.

Abstract: Cyclic polyamide oligomers are prepared by the reaction of various spirobiindane diamines, including spirobiindane bisphenol bis-aminophenoxy ethers, with dicarboxylic acid chloride such as isophthaloyl chloride. The oligomer compositions may be converted to copolyamides by reaction with lactams in the presence of basic reagents.

Abstract: Ink jet apparatus for use with hot melt ink has an integrally connected ink jet head and reservoir system, the reservoir system including a highly efficient heat conducting plate, such as aluminum, inserted within an essentially non-heat conducting reservoir housing. The reservoir system has a sloping flow path between an inlet position and a sump from which ink is drawn to the head, and includes a plurality of vanes situated upon the plate for rapid heat transfer.

Abstract: Cyclic polyphenylene ether-polycarbonate oligomer compositions are prepared from bishaloformates and bisphenols, at least one of which includes a spirobiindane moiety and the other of which is derived from a bisphenol-terminated polyphenylene ether oligomer. The cyclic compositions may be converted to linear copolycarbonates by treatment with a polycarbonate formation catalyst.

Abstract: Macrocyclic oligomers, including polycarbonates, polyesters, polyamides, polyimides, polyetherketones and polyethersulfones, are conveniently prepared from various spiro(bis)indane compounds, especially the 6,6'-difunctional 3,3',3'-tetramethylspiro(bis)indanes. The macrocyclic oligomers may be conveniently converted to linear polymers.