Abstract: This application relates to processes and intermediates for the preparation of the PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3?-((2-(difluoromethyl)-7-((3-hydroxypyrrolidin-1-yl)methyl)pyrido[3,2-d]pyrimidin-4-yl)amino)-2,2?-dimethyl-[1,1?-biphenyl]-3-yl)benzo[d]oxazol-5-yl)methyl)piperidine-4-carboxylic acid, and salts and crystalline forms thereof, where the PD-1/PD-L1 inhibitor and solid forms and salt forms thereof are useful in the treatment of various diseases including infectious diseases and cancer.

Abstract: A method of delivering a substance to a target location of a subject using an insertion apparatus having a base structure with at least one lumen extending along a length thereof, a cladding layer circumferentially surrounding the base structure and an optically-transmissive coating circumferentially surrounding an exterior of the base layer or an exterior of the cladding layer. The method includes inserting the insertion apparatus into the subject to access the target location, transmitting to tissue adjacent the insertion apparatus, a first optical radiation using the optically-transmissive coating or the cladding layer, receiving, from the tissue, at a processor, data characterizing a second optical radiation via the other of the optically-transmissive coating or the cladding layer based on the first optical radiation and determining whether a tip of the base structure is at the target location, and, if so, releasing a substance into or near the target location.

Abstract: A computer-implemented method for participating in a blockchain-based data record distribution process which includes multiple input addresses for input nodes and multiple output addresses for output nodes. One or more input nodes of the group of input nodes perform steps of: collaborating to determine a stealth address, forming a first transaction that pools data records to be transferred to the stealth address, and transmitting the first transaction to be validated and incorporated into the blockchain. One or more output nodes of the group of output nodes perform steps of: searching the blockchain to find the first transaction, identifying the stealth address, forming a second transaction that distributes pooled data records, collaborating via a threshold signature scheme to sign the second transaction, and transmitting the second transaction to be validated and incorporated into the blockchain. The invention may be used in conjunction with any blockchain implementation.

Abstract: A system includes a first mid-rail slit positioned at a first position. A second mid-rail slit is positioned at a second position directly across from the first mid-rail slit. A first and second stile are positioned between the first and second mid-rail slit. The first and second stile are inserted and positioned in a perpendicular direction to a bottom panel to be aligned in a vertical direction between the first and second mid-rail slit. The first and second stile provide separation for a plurality of decorative screen panels. The plurality of decorative screen panels are positioned in contact with the first and second stile.

Abstract: Systems, methods, and devices for managing predetermined functions on a mobile device, the operating system (OS) installed on the device including an event application programming interface (API) configured to enable voice over internet protocol (VoIP) applications to assume priority over other applications and functions of the mobile device when VoIP calls are detected. A mobile device management software application installed and running on the mobile device emulates a VoIP software application and uses event API calls to trick the OS into believing that a VoIP call has been detected and, in response, causes the OS to block or interfere with one or more predetermined functions on the mobile device based on the status and location of the mobile device.

Abstract: Disclosed are compounds of Formula (I): or a pharmaceutically acceptable salt, a tautomer, a stereoisomer, or a deuterated analog thereof, wherein R1, R2, A, E1, E2, and G are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.

Abstract: An implementation of the present application provides a computer-implemented method to increase the security of a blockchain-implemented transaction, the transaction including participation from a plurality of participating nodes, each participating node participating as a message originator, selector, and propagator. The method, implemented at a participating node, includes: receiving ciphertext from a prior node and determining whether the participating node is a selector node for said ciphertext received from the prior node. When the participating node is the selector node for said ciphertext, the method includes selecting a subset of said ciphertext, decrypting the selected subset of said ciphertext to provide opted ciphertext and transmitting said opted ciphertext to the next node. When the participating node is other than the selector node for said ciphertext, the method includes decrypting said ciphertext received from the prior node and transmitting the decrypted ciphertext to the next node.

Abstract: A system is provided for performing transaction mixing between a plurality of users on a blockchain. The system is configured to carry out the steps of: selecting an initiator node to calculate a deterministic hash function using a chosen random number; distribute the deterministic hash function to a plurality of users on the blockchain; choose an amount of time each user is given to construct a payment channel, retrieve the random number, and submit an execution transaction to a blockchain network; choose a second time for when a payment to a user is submitted to the blockchain network; and establish a one-way payment channel between every pair of users in an ordered set of the plurality of users to establish a transaction chain linking all users.

Abstract: A drilling assembly for downhole to surface communications is provided. The drilling assembly includes a series of pipe segments coupled in fluid communication between a slip ring assembly and an end pipe portion. The slip ring assembly is coupled in data and fluid communication with the pipe segments. A surface communications link is in data communication with the drilling assembly via the slip ring assembly. An end pipe portion is coupled with the drilling assembly that includes an electronics assembly with electronic components for transferring data to the slip ring assembly via the drilling assembly. A drill bit is operably coupled with the end pipe portion for drilling a borehole. Each pipe segment includes an outer conductor portion, a hollow inner conductor portion, and a dielectric portion for electrical isolation between the outer conductor portion and the inner conductor portion.

Abstract: A device for attaching to a ski of a snowmobile includes first and second spaced apart legs. Each leg has a ski engaging portion proximate a second end that is configured to engage a bottom surface of the ski proximate outer edges thereof. The device includes at least one wheel attached to the first and second legs between the first end and the second end and a cross bar that attaches the first and second legs proximate first ends thereof. The device includes a lever arm extending from the cross bar between the first and second legs wherein the lever arm is configured to be angularly positionable relative to the first and second spaced apart legs. A handle is attached to a distal end of the lever arm and has a surface configured to engage a tip end or a ski handle of the ski.

Abstract: A device for attaching to a ski of a snowmobile includes first and second spaced apart legs. Each leg has a ski engaging portion proximate a second end that is configured to engage a bottom surface of the ski proximate outer edges thereof. The device includes at least one wheel attached to the first and second legs between the first end and the second end and a cross bar that attaches the first and second legs proximate first ends thereof. The device includes a lever arm extending from the cross bar between the first and second legs wherein the lever arm is configured to be angularly positionable relative to the first and second spaced apart legs. A handle is attached to a distal end of the lever arm and has a surface configured to engage a tip end or a ski handle of the ski.

Abstract: Examples disclosed herein relate to processing health information of a computing device according to a deep learning model to determine whether an anomaly has occurred. Multiple computing devices can be part of a system. One of the computing devices includes a host processing element, a management controller separate from the host processing element, and a deep learning model that includes parameters that are trained to identify anomalistic behavior for the computing device. The management controller can receive health information from multiple components of the computing device and process the health information according to the deep learning model to determine whether an anomaly occurred.

Abstract: In some examples, a management controller includes a communication interface to communicate with a computing device, where the management controller is separate from a processor of the computing device. The management controller includes a management processor to receive, from the computing device, a first hash value that is based on a first hash function applied on an input value and a salt, generate a second hash value based on applying a second hash function on the first hash value and a pepper, and send the second hash value to the computing device.

Abstract: A device for attaching to a ski of a snowmobile includes first and second spaced apart legs. Each leg has a ski engaging portion proximate a second end that is configured to engage a bottom surface of the ski proximate outer edges thereof. The device includes at least one wheel attached to the first and second legs between the first end and the second end and a cross bar that attaches the first and second legs proximate first ends thereof. The device includes a lever arm extending from the cross bar between the first and second legs wherein the lever arm is configured to be angularly positionable relative to the first and second spaced apart legs. A handle is attached to a distal end of the lever arm and has a surface configured to engage a tip end or a ski handle of the ski.

Abstract: In some examples, a management controller includes a communication interface to communicate with a computing device, where the management controller is separate from a processor of the computing device. The management controller includes a management processor to perform a validation of program codes of virtual entities of the computing device, and in response to the validation of the program codes, unlock access of information in an information store to allow access of the information by the computing device, wherein the information is for use by the virtual entities of the computing device, and wherein the management processor is to block access of the information in the information store prior to the validation.

Abstract: A device for attaching to a ski of a snowmobile includes first and second spaced apart legs. Each leg has a ski engaging portion proximate a second end that is configured to engage a bottom surface of the ski proximate outer edges thereof. The device includes at least one wheel attached to the first and second legs between the first end and the second end and a cross bar that attaches the first and second legs proximate first ends thereof. The device includes a lever arm extending from the cross bar between the first and second legs wherein the lever arm is configured to be angularly positionable relative to the first and second spaced apart legs. A handle is attached to a distal end of the lever arm and has a surface configured to engage a tip end or a ski handle of the ski.

Abstract: A system and method for real-time risk-assessment and adjustment, risks associated with a plurality of risk exposed individuals being at least partially transferable from a risk exposed individual to a first insurance system and/or from the first insurance system to an associated second insurance system. The system including a table with retrievable stored risk classes each comprising assigned risk class criteria, individual-specific parameters of the risk exposed individuals being captured relating to criteria of the stored risk classes by the system and stored in a memory, and a specific risk class associated with the risk of the exposed individual being identified out and selected of the stored risk classes by the system based on the captured parameters.

Abstract: A device for attaching to a ski of a snowmobile includes first and second spaced apart legs includes a ski engaging portion that is configured to engage a bottom surface of the ski. At least one wheel is attached to the first and second legs. A cross bar connects the first and second legs proximate first ends thereof. A lever arm extending from the cross bar and is angularly positionable relative to the first and second spaced apart legs. A retaining member is attached to a distal end of the lever arm and has a surface configured to engage a tip end or a ski handle of the ski.

Abstract: In some examples, a management controller includes a communication interface to communicate with a computing device, where the management controller is separate from a processor of the computing device. The management controller includes a management processor to receive, from the computing device, a first hash value that is based on a first hash function applied on an input value and a salt, generate a second hash value based on applying a second hash function on the first hash value and a pepper, and send the second hash value to the computing device.

Abstract: In some examples, a management controller includes a communication interface to communicate with a computing device, where the management controller is separate from a processor of the computing device. The management controller includes a management processor to perform a validation of program codes of virtual entities of the computing device, and in response to the validation of the program codes, unlock access of information in an information store to allow access of the information by the computing device, wherein the information is for use by the virtual entities of the computing device, and wherein the management processor is to block access of the information in the information store prior to the validation.