Patents by Inventor Joseph Y. Lucisano
Joseph Y. Lucisano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10561351Abstract: A tissue-implantable sensor for measurement of solutes in fluids and gases, such as oxygen and glucose, is provided. The sensor includes: i) a detector array including at least one detector; ii) a telemetry transmission portal; iii) an electrical power source; and iv) circuitry electrically connected to the detector array including signal processing means for determining an analyte level, such as glucose level, in a body fluid contacting the detectors. The sensor components are disposed in a hermetically sealed housing having a size and shape suitable for comfortable, safe, and unobtrusive subcutaneous implantation allowing for in vivo detection and long term monitoring of tissue glucose concentrations by wireless telemetry.Type: GrantFiled: July 26, 2012Date of Patent: February 18, 2020Assignee: GLYSENS INCORPORATEDInventors: Joseph Y. Lucisano, Mark B. Catlin, William J. Choi, Payton C. Chu, Joe T. Lin, Timothy L. Routh, Thomas G. Wallner
-
Publication number: 20200037932Abstract: A tissue-implantable sensor for measurement of solutes in fluids and gases, such as oxygen and glucose, is provided. The sensor includes: i) a detector array including at least one detector; ii) a telemetry transmission portal; iii) an electrical power source; and iv) circuitry electrically connected to the detector array including signal processing means for determining an analyte level, such as glucose level, in a body fluid contacting the detectors. The sensor components are disposed in a hermetically sealed housing having a size and shape suitable for comfortable, safe, and unobtrusive subcutaneous implantation allowing for in vivo detection and long term monitoring of tissue glucose concentrations by wireless telemetry.Type: ApplicationFiled: October 14, 2019Publication date: February 6, 2020Inventors: Joseph Y. Lucisano, Mark B. Catlin, William J. Choi, Payton C. Chu, Joe T. Lin, Timothy L. Routh, Thomas G. Wallner
-
Publication number: 20190246957Abstract: A tissue-implantable sensor for measurement of solutes in fluids and gases, such as oxygen and glucose, is provided. The sensor includes: i) a detector array including at least one detector; ii) a telemetry transmission portal; iii) an electrical power source; and iv) circuitry electrically connected to the detector array including signal processing means for determining an analyte level, such as glucose level, in a body fluid contacting the detectors. The sensor components are disposed in a hermetically sealed housing having a size and shape suitable for comfortable, safe, and unobtrusive subcutaneous implantation allowing for in vivo detection and long term monitoring of tissue glucose concentrations by wireless telemetry.Type: ApplicationFiled: January 24, 2019Publication date: August 15, 2019Inventors: Joseph Y. Lucisano, Mark B. Catlin, William J. Choi, Payton C. Chu, Joseph T. Lin, Timothy L. Routh, Thomas G. Wallner
-
Publication number: 20180348154Abstract: At least one conductor is formed at a preselected location on a substrate made of a first insulating material having a high temperature resistance. The conductor is made from a solidified electrically conductive thick film material. A coating made of a second insulating material is formed over the substrate to hermetically seal at least a portion of the conductor. An exposed distal region of the conductor provides a detection electrode. The conductor has a reduced porosity that inhibits migration of fluid or constituents thereof through the conductor.Type: ApplicationFiled: August 6, 2018Publication date: December 6, 2018Inventors: Joseph Y. Lucisano, Mark B. Catlin
-
Patent number: 10041897Abstract: At least one conductor is formed at a preselected location on a substrate made of a first insulating material having a high temperature resistance. The conductor is made from a solidified electrically conductive thick film material. A coating made of a second insulating material is formed over the substrate to hermetically seal at least a portion of the conductor. An exposed distal region of the conductor provides a detection electrode. The conductor has a reduced porosity that inhibits migration of fluid or constituents thereof through the conductor.Type: GrantFiled: February 9, 2011Date of Patent: August 7, 2018Assignee: Glysens, Incorporated, a California CorporationInventors: Joseph Y. Lucisano, Mark B. Catlin
-
Patent number: 9782111Abstract: A wire extends through a ceramic body. The wire comprises a material selected from the group consisting of platinum, palladium, rhodium, iridium, osmium and alloys of platinum, palladium, rhodium, iridium, and osmium. The wire directly contacts the ceramic body to form a substantially hermetic seal between the ceramic body and the wire.Type: GrantFiled: June 25, 2014Date of Patent: October 10, 2017Assignee: GlySense, Inc., a California CorporationInventors: Joseph Y. Lucisano, Richard E. Calou, Mark B. Catlin, Joe T. Lin, Timothy L. Routh
-
Publication number: 20140309510Abstract: A wire extends through a ceramic body. The wire comprises a material selected from the group consisting of platinum, palladium, rhodium, iridium, osmium and alloys of platinum, palladium, rhodium, iridium, and osmium. The wire directly contacts the ceramic body to form a substantially hermetic seal between the ceramic body and the wire.Type: ApplicationFiled: June 25, 2014Publication date: October 16, 2014Inventors: Joseph Y. Lucisano, Richard E. Calou, Mark B. Catlin, Joe T. Lin, Timothy L. Routh
-
Patent number: 8763245Abstract: A wire extends through a ceramic body. The wire comprises a material selected from the group consisting of platinum, palladium, rhodium, iridium, osmium and alloys of platinum, palladium, rhodium, iridium, and osmium. The wire directly contacts the ceramic body to form a substantially hermetic seal between the ceramic body and the wire.Type: GrantFiled: June 30, 2006Date of Patent: July 1, 2014Assignee: Glysens, Inc., a California CorporationInventors: Joseph Y. Lucisano, Richard E. Calou, Mark B. Catlin, Joe T. Lin, Timothy L. Routh
-
Publication number: 20130197332Abstract: A tissue-implantable sensor for measurement of solutes in fluids and gases, such as oxygen and glucose, is provided. The sensor includes: i) a detector array including at least one detector; ii) a telemetry transmission portal; iii) an electrical power source; and iv) circuitry electrically connected to the detector array including signal processing means for determining an analyte level, such as glucose level, in a body fluid contacting the detectors. The sensor components are disposed in a hermetically sealed housing having a size and shape suitable for comfortable, safe, and unobtrusive subcutaneous implantation allowing for in vivo detection and long term monitoring of tissue glucose concentrations by wireless telemetry.Type: ApplicationFiled: July 26, 2012Publication date: August 1, 2013Inventors: Joseph Y. Lucisano, Mark B. Catlin, William J. Choi, Payton C. Chu, Joe T. Lin, Timothy L. Routh, Thomas G. Wallner
-
Publication number: 20110137142Abstract: At least one conductor is formed at a preselected location on a substrate made of a first insulating material having a high temperature resistance. The conductor is made from a solidified electrically conductive thick film material. A coating made of a second insulating material is formed over the substrate to hermetically seal at least a portion of the conductor. An exposed distal region of the conductor provides a detection electrode. The conductor has a reduced porosity that inhibits migration of fluid or constituents thereof through the conductor.Type: ApplicationFiled: February 9, 2011Publication date: June 9, 2011Inventors: Joseph Y. Lucisano, Mark B. Catlin
-
Patent number: 7894870Abstract: At least one conductor is formed at a preselected location on a substrate made of a first insulating material having a high temperature resistance. The conductor is made from a solidified electrically conductive thick film material. A coating made of a second insulating material is formed over the substrate to hermetically seal at least a portion of the conductor. An exposed distal region of the conductor provides a detection electrode. The conductor has a reduced porosity that inhibits migration of fluid or constituents thereof through the conductor.Type: GrantFiled: August 23, 2004Date of Patent: February 22, 2011Assignee: Glysens, IncorporatedInventors: Joseph Y. Lucisano, Mark B. Catlin
-
Patent number: 7871456Abstract: A membrane for use in an implantable glucose sensor including at least one crosslinked substantially hydrophobic polymer and at least one crosslinked substantially hydrophilic polymer; wherein the first and second polymers are different polymers and substantially form an interpenetrating polymer network, semi-interpenetrating polymer network, polymer blend, or copolymer. The membranes are generally characterized by providing a permeability ratio of oxygen to glucose of about 1 to about 1000 in units of (mg/dl glucose) per (mmHg oxygen). Three methods of making membranes from hydrophobic and hydrophilic monomers formed into polymer networks are provided, wherein according to at least two of the methods, the monomers may be substantially immiscible with one another.Type: GrantFiled: August 10, 2006Date of Patent: January 18, 2011Assignee: The Regents of the University of CaliforniaInventors: David A. Gough, Joseph Y. Lucisano, Joe T. Lin, Hwai-Min Tsay, Drahoslav Lim, Jana Limova, legal representative
-
Patent number: 7336984Abstract: The invention is the design of a biological measuring device for the determination of the concentration of biomolecules (e.g. glucose) in an environment which is designed for implantation into an individual or for use in the context of an external apparatus. The device contains a composite membrane that is essentially entirely permeable to oxygen and permeable to larger biomolecules only in discrete hydrophilic regions. The membrane diffusionally limits the access of biomolecules to an enzyme, present in the hydrophilic region that catalyzes the oxidation of the biomolecule to produce hydrogen peroxide. A sensor in communication with the hydrophilic region is used to determine the amount of product produced or the amount of excess oxygen present allowing for the concentration of the biomolecule to be determined.Type: GrantFiled: November 20, 2003Date of Patent: February 26, 2008Assignee: The Regents of the University of CaliforniaInventors: David A. Gough, Joseph Y. Lucisano
-
Publication number: 20080034972Abstract: A membrane for use in an implantable glucose sensor including at least one crosslinked substantially hydrophobic polymer and at least one crosslinked substantially hydrophilic polymer; wherein the first and second polymers are different polymers and substantially form an interpenetrating polymer network, semi- interpenetrating polymer network, polymer blend, or copolymer. The membranes are generally characterized by providing a permeability ratio of oxygen to glucose of about 1 to about 1000 in units of (mg/dl glucose) per (mmHg oxygen). Three methods of making membranes from hydrophobic and hydrophilic monomers formed into polymer networks are provided, wherein according to at least two of the methods, the monomers may be substantially immiscible with one another.Type: ApplicationFiled: August 10, 2006Publication date: February 14, 2008Inventors: David A. Gough, Joseph Y. Lucisano, Joe T. Lin, Hwai-Min Tsay, Drahoslav Lim
-
Patent number: 7248912Abstract: A tissue-implantable sensor for measurement of solutes in fluids and gases, such as oxygen and glucose, is provided. The sensor includes a multiplicity of detectors, constructed and arranged to improve the probability that one or more detectors will have access to a vascular source at points in time sufficient to permit accurate measurements to be taken. Means and methods for calculating solute levels using the sensor device of the invention are also provided.Type: GrantFiled: October 31, 2003Date of Patent: July 24, 2007Assignee: The Regents of the University of CaliforniaInventors: David A. Gough, Michael C. Jablecki, Joseph Y. Lucisano, Mark B. Catlin
-
Patent number: 7235350Abstract: A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zirconia or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at a relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.Type: GrantFiled: October 20, 2004Date of Patent: June 26, 2007Assignee: Alfred E. Mann FoundationInventors: Joseph H. Schulman, Joseph Y. Lucisano, Rajiv Shah, Charles L. Byers, Shaun M. Pendo
-
Patent number: 7160672Abstract: A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zerconia, or other ceramic, less than 25 microns thick, e.g., 5–10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.Type: GrantFiled: June 10, 2005Date of Patent: January 9, 2007Assignee: Alfred E. Mann Foundation for Scientific ResearchInventors: Joseph H. Schulman, Joseph Y. Lucisano, Rajiv Shah, Charles L. Byers, Shaun M. Pendo
-
Patent number: 6844023Abstract: A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zirconia or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.Type: GrantFiled: September 20, 2002Date of Patent: January 18, 2005Assignee: Medtronic Minimed, Inc.Inventors: Joseph H. Schulman, Joseph Y. Lucisano, Rajiv Shah, Charles L. Byers, Shaun M. Pendo
-
Publication number: 20030087197Abstract: A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zerconia, or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.Type: ApplicationFiled: September 20, 2002Publication date: May 8, 2003Applicant: Alfred E. Mann FoundationInventors: Joseph H. Schulman, Joseph Y. Lucisano, Rajiv Shah, Charles L. Byers, Shaun M. Pendo
-
Patent number: 6472122Abstract: A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zerconia, or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.Type: GrantFiled: September 9, 1999Date of Patent: October 29, 2002Assignee: Medtronic Minimed, Inc.Inventors: Joseph H. Schulman, Joseph Y. Lucisano, Rajiv Shah, Charles L. Byers, Shaun M. Pendo