Patents by Inventor Josephine Allen

Josephine Allen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240026334
    Abstract: Disclosed herein are compositions comprising magnetoelectric composite materials and collagen, along with uses and kits thereof. Described herein is the use of DNA aptamer assemblies of varying DNA length, structure, and sequence to both bind to collagen and other proteins, to then act as a biocompatible, degradable, reversible, or permanent 3D crosslinkers between proteins, and to service as a biologically functional material when using the appropriate aptamer sequence. Therefore, disclosed herein are compositions comprising collagen fibers crosslinked with DNA aptamers. Also disclosed are devices and implants made from or coated with collagen fibers crosslinked with DNA aptamers. Also disclosed are methods of making collagen fibers. Also disclosed are kits for producing collagen fibers. Also disclosed herein are compositions DNA aptamers in a collagen fiber matrix that stabilizes the DNA aptamer.
    Type: Application
    Filed: September 10, 2021
    Publication date: January 25, 2024
    Inventors: Josephine ALLEN, Jennifer S. ANDREW, Noah D. FERSON, Bryan D. JAMES
  • Publication number: 20230382976
    Abstract: Disclosed herein is the use of DNA aptamer assemblies of varying DNA length, structure, and sequence to both bind to collagen and other ECM proteins, to then act as a biocompatible, degradable, reversible, or permanent 3D crosslinkers between proteins, and to service as a biologically functional material when using the appropriate aptamer sequence. Therefore, disclosed herein are compositions comprising collagen fibers and additional ECM components crosslinked with DNA aptamers. Also disclosed are devices and implants made from or coated with collagen fibers and additional ECM components crosslinked with DNA aptamers. Also disclosed are methods of making collagen fibers. Also disclosed are kits for producing collagen fibers.
    Type: Application
    Filed: May 5, 2023
    Publication date: November 30, 2023
    Inventors: Bryan D. JAMES, Josephine ALLEN
  • Patent number: 11730971
    Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, and the like.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: August 22, 2023
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Jon P. Dobson, Josephine Allen
  • Publication number: 20220331405
    Abstract: Disclosed herein is the use of DNA aptamer assemblies of varying DNA length, structure, and sequence to both bind to collagen and other proteins, to then act as a biocompatible, degradable, reversible, or permanent 3D crosslinkers between proteins, and to service as a biologically functional material when using the appropriate aptamer sequence. Therefore, disclosed herein are compositions comprising collagen fibers crosslinked with DNA aptamers. Also disclosed are devices and implants made from or coated with collagen fibers crosslinked with DNA aptamers. Also disclosed are methods of making collagen fibers. Also disclosed are kits for producing collagen fibers. Also disclosed herein are compositions DNA aptamers in a collagen fiber matrix that stabilizes the DNA aptamer.
    Type: Application
    Filed: August 28, 2020
    Publication date: October 20, 2022
    Inventors: Bryan D. JAMES, Josephine ALLEN
  • Publication number: 20220235309
    Abstract: Described herein are bioreactor chambers and systems thereof. In an embodiment, a single-plate symmetrical bioreactor chamber is described, comprising: a flow channel extending along a first axis, wherein the flow channel comprises an inlet and an outlet at opposing ends of 5 the flow channel; a pair of struts on opposing ends of a second axis, wherein the second axis is substantially perpendicular to the first axis, wherein each strut of the pair of struts are placed on opposing sides of the flow channel, wherein the struts are configured to be coupled to a bidirectional linear actuator and configured to provide a strain perpendicular to a fluid flow through the flow channel, wherein the strain does not laterally displace cells present in the flow channel.
    Type: Application
    Filed: January 10, 2020
    Publication date: July 28, 2022
    Inventors: Josephine ALLEN, Bryan D. JAMES
  • Publication number: 20210388164
    Abstract: Described herein are methods of preparing protein scaffolds that can include the step of crosslinking protein fibers in the vapor phase of a natural aldehyde, such as cinnamaldehyde or vanillin or a solution thereof. Also described herein are protein scaffolds that can be prepared by a method that can include the step of crosslinking protein fibers in the vapor phase of a natural aldehyde solution, such as cinnamaldehyde or vanillin or a solution thereof.
    Type: Application
    Filed: October 1, 2019
    Publication date: December 16, 2021
    Inventors: Josephine ALLEN, Vidhya RAMASWAMY, Krista DULANY, Allison N. GOINS
  • Patent number: 11053572
    Abstract: Disclosed herein is an article comprising a metal alloy; where the metal alloy comprises a base metal, a second element and a third element; where the base metal is magnesium, calcium, strontium, zinc, or a combination thereof; where the second element is chemically different from the third element; and where the second element and the third element are scandium, yttrium, gadolium, cerium, neodymium, dysporium, or a combination thereof; and a protective layer disposed upon the metal alloy and is reactively bonded to the metal alloy; where the protective layer comprises a base non-metallic derivative, a second non-metallic derivative and a third non-metallic derivative of metals present in the metal alloy; and where the base non-metallic derivative, the second non-metallic derivative and the third non-metallic derivative are all chemically different from one another.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: July 6, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Michele Manuel, Josephine Allen, Jordan P. Ball, Harpreet Singh Brar, Ida Svensson Berglund
  • Publication number: 20210154371
    Abstract: Various embodiments of biocompatible textile mesh and tissue constructs from Manicaria saccifera, methods of growing cells and tissues using the Manicaria saccifera-based textile mesh/tissue scaffolds, and methods of treating subjects with the biocompatible textile mesh and tissue constructs are described. The mesh, constructs and methods can include a biocompatible textile mesh made from a naturally woven fiber mat from a Manicaria saccifera palm bract that has been treated to remove oils and lignin from the surface of palm fibers in the mat and seeded with a population of cells. An engineered, biocompatible tissue construct, a method of growing mammalian tissue in vivo, and a method of treating a subject are also described.
    Type: Application
    Filed: November 20, 2020
    Publication date: May 27, 2021
    Inventors: Josephine ALLEN, Juan Claudio NINO
  • Publication number: 20200353276
    Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, and the like.
    Type: Application
    Filed: July 28, 2020
    Publication date: November 12, 2020
    Inventors: Jon P. DOBSON, Josephine ALLEN
  • Patent number: 10765881
    Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, and the like.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: September 8, 2020
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Jon P. Dobson, Josephine Allen
  • Publication number: 20190194782
    Abstract: Disclosed herein is an article comprising a metal alloy; where the metal alloy comprises a base metal, a second element and a third element; where the base metal is magnesium, calcium, strontium, zinc, or a combination thereof; where the second element is chemically different from the third element; and where the second element and the third element are scandium, yttrium, gadolium, cerium, neodymium, dysporium, or a combination thereof; and a protective layer disposed upon the metal alloy and is reactively bonded to the metal alloy; where the protective layer comprises a base non-metallic derivative, a second non-metallic derivative and a third non-metallic derivative of metals present in the metal alloy; and where the base non-metallic derivative, the second non-metallic derivative and the third non-metallic derivative are all chemically different from one another.
    Type: Application
    Filed: February 15, 2019
    Publication date: June 27, 2019
    Inventors: Michele Manuel, Josephine Allen, Jordan P. Ball, Harpreet Singh Brar, Ida Svensson BERGLUND
  • Patent number: 10266922
    Abstract: Disclosed herein is an article comprising a metal alloy; where the metal alloy comprises a base metal, a second element and a third element; where the base metal is magnesium, calcium, strontium, zinc, or a combination thereof; where the second element is chemically different from the third element; and where the second element and the third element are scandium, yttrium, gadolium, cerium, neodymium, dysporium, or a combination thereof; and a protective layer disposed upon the metal alloy and is reactively bonded to the metal alloy; where the protective layer comprises a base non-metallic derivative, a second non-metallic derivative and a third non-metallic derivative of metals present in the metal alloy; and where the base non-metallic derivative, the non-second metallic derivative and the third non-metallic derivative are all chemically different from one another.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: April 23, 2019
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC.
    Inventors: Michele Viola Manuel, Josephine Allen, Jordan P. Ball, Harpreet Singh Brar, Ida Svensson Berglund
  • Publication number: 20180353768
    Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, and the like.
    Type: Application
    Filed: January 5, 2017
    Publication date: December 13, 2018
    Inventors: Jon P. Dobson, Josephine Allen
  • Publication number: 20160194738
    Abstract: Disclosed herein is an article comprising a metal alloy; where the metal alloy comprises a base metal, a second element and a third element; where the base metal is magnesium, calcium, strontium, zinc, or a combination thereof; where the second element is chemically different from the third element; and where the second element and the third element are scandium, yttrium, gadolium, cerium, neodymium, dysporium, or a combination thereof; and a protective layer disposed upon the metal alloy and is reactively bonded to the metal alloy; where the protective layer comprises a base non-metallic derivative, a second non-metallic derivative and a third non-metallic derivative of metals present in the metal alloy; and where the base metallic derivative, the second metallic derivative and the third metallic derivative are all chemically different from one another.
    Type: Application
    Filed: July 3, 2014
    Publication date: July 7, 2016
    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC.
    Inventors: Michele Viola MANUEL, Josephine ALLEN, Jordan P. BALL, Harpreet Singh BRAR, Ida Svensson BERGLUND
  • Publication number: 20060155178
    Abstract: A method of examining a sample includes measuring, as function of wavelength of light elastically scattered from the sample, at least 2 properties, selected from the group consisting of scattering angle theta of the light, scattering angle phi of the light, and polarization of the light. The scattering angle theta is an angle between backward direction and direction of propagation of the light, and scattering angle phi is an angle between incident light polarization and projection of direction of the light propagation onto a plane in which incident electric field oscillates.
    Type: Application
    Filed: October 27, 2005
    Publication date: July 13, 2006
    Inventors: Vadim Backman, Hemant Roy, Ramesh Wali, Young Kim, Yang Liu, Guillermo Ameer, Jian Yang, Antonio Webb, Josephine Allen