Patents by Inventor Joshua A. Shreve
Joshua A. Shreve has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11982474Abstract: The present disclosure relates to methodologies, systems and apparatus for cooling pump heads and providing balanced cooling and heat transfer between multiple pump heads. Multi-pump systems that are used to pump fluids that vary greatly in density with minor changes in temperature, such as the mobile phase of a C02-based chromatography system, require highly stable temperature conditions. In order to achieve a substantially equal average heat transfer between multiple pump heads and a coolant fluid, coolant fluid may be flowed through coolant passageways within the pump heads in a recursive and/or parallel coolant flow patterns. Such recursive and/or parallel coolant fluid flow patterns provide increased stability in temperature, compressibility, and density of the fluids passing through a multi-pump system.Type: GrantFiled: April 1, 2020Date of Patent: May 14, 2024Assignee: Waters Technologies CorporationInventors: Michael R. Jackson, Christopher Seith, Nathan Barrett, Kara O'donnell, Neal B. Almeida, Wen Lu, James E. Usowicz, Maruth Sok, Kurt D. Joudrey, Joshua A. Shreve
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Patent number: 11958084Abstract: A cleaning device, and method of using the same, for cleaning a probe. The device includes a body defining an inner chamber. An air intake is connected to at least one air channel through the body, the at least one air channel configured to allow air from the air intake to flow into the inner chamber and towards the inner chamber. A liquid intake is connected to at least one liquid channel through the body, the at least one liquid channel configured to allow liquid from the liquid intake to flow into the inner chamber.Type: GrantFiled: July 30, 2021Date of Patent: April 16, 2024Assignee: INSTRUMENTATION LABORATORY COMPANYInventors: Jo-Ann Loh, Joshua Shreve, Chison Liu
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Publication number: 20230266350Abstract: An example medical diagnostic system includes one or more containers that are usable in a medical diagnostic test. Each container has an identification (ID) tag associated therewith. An ID tag of a container includes memory that is readable and writeable. The memory is for storing information relating to the container. Antennas are configured to communicate wirelessly with ID tags associated with the one or more containers. A control system is configured to store a location of the container based on an identify of the antenna, to select the antenna for communication with the ID tag, and to use the antenna to read at least some of the information from, or to write at least some of the information to, the memory on the ID tag.Type: ApplicationFiled: February 23, 2022Publication date: August 24, 2023Inventors: Christopher Farren, Adam Atkins, Joshua Shreve, Benjamin Newton, Renen Bassik, Jonas Ciemny, Linda Elizabeth Akagla
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Patent number: 11707809Abstract: The present technology generally relates to devices, systems and methods for providing robust sealing between surfaces in a pressurized system, such as a chromatography system. In particular, the devices, systems and methods relate to compliant and resilient parts that can be reused and/or reinstalled while providing a pressure tight sealing surface even within a high pressure environment (e.g., 1000 psi or greater).Type: GrantFiled: May 13, 2020Date of Patent: July 25, 2023Assignee: Waters Technologies CorporationInventors: Emily J. Berg, Joshua A. Shreve
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Publication number: 20230213543Abstract: Systems and methods for probe tip heating are disclosed. An exemplary system for probe tip heating can include an enclosure enclosing a probe tip, a heating device, and a fan. The probe tip can be configured to access an internal volume of a stoppered container and to aspirate or dispense a material from or to the internal volume of the stoppered container. The heating device can be configured to heat air circulating within the enclosure.Type: ApplicationFiled: December 31, 2021Publication date: July 6, 2023Applicant: Instrumentation Laboratory CompanyInventors: Chris Christoff, Joshua A. Shreve, Reed Hebert, Benjamin Newton
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Publication number: 20230139694Abstract: Operations performed according to the example techniques described herein include controlling a probe to pierce a stopper of a container containing a substance, where the stopper provides an air-tight seal for the container, and where the air-tight seal supports an internal pressure in the container. The operations also include detecting the internal pressure based on information from a pressure sensor; determining that the internal pressure is not at a target pressure and, based on determining that the internal pressure is not at the target pressure, controlling the probe either to aspirate air from the container or to dispense air into the container in order to move the internal pressure toward the target pressure.Type: ApplicationFiled: November 4, 2021Publication date: May 4, 2023Inventors: Demetrio Sanchez-Martinez, Joshua Shreve
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Publication number: 20230033049Abstract: A cleaning device, and method of using the same, for cleaning a probe. The device includes a body defining an inner chamber. An air intake is connected to at least one air channel through the body, the at least one air channel configured to allow air from the air intake to flow into the inner chamber and towards the inner chamber. A liquid intake is connected to at least one liquid channel through the body, the at least one liquid channel configured to allow liquid from the liquid intake to flow into the inner chamber.Type: ApplicationFiled: July 30, 2021Publication date: February 2, 2023Applicant: Instrumentation Laboratory CompanyInventors: Jo-ann Loh, Joshua Shreve, Chison Liu
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Method and apparatus for minimizing the chromatographic band distortion of a back pressure regulator
Patent number: 11554331Abstract: The technology generally relates to tailoring a back pressure regulator in a chromatographic system to reduce unswept volume within the back pressure regulator to achieve better sample detection and a reduction in chromatographic band distortion effects.Type: GrantFiled: May 13, 2020Date of Patent: January 17, 2023Assignee: Waters Technologies CorporationInventors: Michael O. Fogwill, Joseph D. Michienzi, Joshua A. Shreve, Scott Kelley, Emily J. Berg -
Publication number: 20230008204Abstract: The embodiments of the present disclosure provide a pierceable stopper, comprising a plug portion, and a disk portion disposed on top of the plug portion and comprising a flange extending radially beyond an outer diameter of the plug portion. The embodiments also provide a lyophilization stopper, comprising a body comprising an integral hinge means, and a flange extending radially beyond an outer diameter of the body. Additionally, the embodiments provide a probe assembly, comprising a first needle comprising a hollow cavity and a pointed tip, and a second needle disposed inside the hollow cavity and comprising a rounded tip. The embodiments further provide a cartridge assembly, comprising a first housing comprising a first set of cavities configured to accommodate one or more containers, and a second housing comprising a second set of cavities corresponding to the first set of cavities when the second housing is coupled to the first housing.Type: ApplicationFiled: July 8, 2021Publication date: January 12, 2023Applicant: Instrumentation Laboratory CompanyInventors: Christopher FARREN, Joshua A. SHREVE, Hugh FOLSOM
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Patent number: 11400390Abstract: The present disclosure relates to an apparatus for regulating the average mobile phase density or pressure in a carbon dioxide based separation system. The apparatus includes a controller, a set of pressure or density sensors and a set of instructions capable of determining the pressure drop across a column and adjusting at least one system component or parameter to achieve a pre-determined average mobile phase density or pressure in the system.Type: GrantFiled: August 26, 2019Date of Patent: August 2, 2022Assignee: Waters Technologies CorporationInventor: Joshua A. Shreve
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Patent number: 11378556Abstract: The present disclosure relates to methodologies, systems, apparatus, and kits for controlling fluid flow within a chromatography system. A makeup pump is configured to pump a makeup fluid into the chromatography system downstream of the column. A first restrictor is located upstream of a detector and downstream of both the makeup pump and the column. Decreasing an output volume of the makeup pump can direct an output from the column through the first restrictor to the detector. Increasing an output volume of the makeup pump can direct the output from the column to a second restrictor located downstream of the makeup pump and the column and in parallel with the first restrictor and the detector.Type: GrantFiled: May 29, 2019Date of Patent: July 5, 2022Assignee: Waters Technologies CorporationInventors: Michael O. Fogwill, Thomas S. McDonald, Joshua A. Shreve
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Patent number: 11319122Abstract: A pierceable self-resealing stopper for a container is disclosed. The disclosed stopper is suitable for sealing a container containing reagents for use in a high-throughput analysis system in which reagents in the container are accessed by an aspirator probe piercing the stopper. The stopper is configured for being pierced and resealing itself a large number of times without degradation of the stopper by coring or fragmentation, for example. A set of protrusions extending from a top surface of the stopper is depressed to stretch a thin diaphragm area between the protrusions prior to and during insertion of the probe. After extraction of the probe, the protrusions are allowed to return to a relaxed state, which discontinues stretching of the diaphragm area and reseals the container.Type: GrantFiled: January 2, 2020Date of Patent: May 3, 2022Assignee: INSTRUMENTATION LABORATORY COMPANYInventors: Christopher Francis Farren, Joshua A. Shreve
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Patent number: 11237137Abstract: A column-conditioning enclosure includes a column chamber adapted to hold one or more chromatography separation columns. A duct system provides an airflow path around the column chamber such that the one or more chromatography separation columns held within the column chamber are isolated from the airflow path. An air mover disposed in the airflow path generates a flow of air within the duct system. A heat exchanger system disposed in the airflow path near the air to exchange heat with the air as the air flows past the heat exchanger system. The air circulates through the duct system around the column chamber, convectively exchanging heat with the column chamber to produce a thermally conditioned environment for the one or more chromatography separation columns held within the column chamber.Type: GrantFiled: April 10, 2015Date of Patent: February 1, 2022Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Joshua A. Shreve, Kurt D. Joudrey
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Patent number: 11143634Abstract: Methodologies, systems, and computer-readable media are provided for controlling the mass flow rate within a CO2 based chromatography system. The pressure within a CO2 pump is measured and received at a computing system, and the computing system retrieves a target temperature value corresponding to the new pressure measurement within the CO2 pump. The computing system then generates a temperature control command that controls a CO2 pump heater or cooler in order to achieve the target temperature value at the CO2 pump. Thus, a target mass flow rate of CO2 from the CO2 pump is achieved by adjusting the temperature of the CO2 pump in response to changes in pressure.Type: GrantFiled: October 26, 2018Date of Patent: October 12, 2021Assignee: Waters Technologies CorporationInventors: Abhijit Tarafder, Jason Hill, Joshua Shreve
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Patent number: 11105780Abstract: The invention provides compression fittings and methods of assembling compression fittings. In exemplary embodiments, compression fittings are provided that include a fitting body, a ferrule and a tube. For example, the fitting body can be removably coupled to the ferrule when the tube is disposed therethrough.Type: GrantFiled: May 7, 2014Date of Patent: August 31, 2021Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Sylvain Cormier, Kurt D. Joudrey, Joshua A. Shreve
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Patent number: 11020687Abstract: Methods for transferring a separation procedure from a first chromatographic system to a second one are disclosed that involve substantially matching a pressure profile. In some such methods, a length, an area, and a particle size of a first column in the first system and a flow rate in the first separation procedure are identifiable. Some such methods also involve selecting a combination of a length, an area, and a particle size of a second column in the second system and a flow rate for the second separation procedure. These methods may involve calculating a target length, a target area, or a target particle size for the second column in the second system or a target flow rate for the second separation procedure.Type: GrantFiled: April 9, 2018Date of Patent: June 1, 2021Assignee: Waters Technologies CorporationInventors: Jason F. Hill, Michael O. Fogwill, Joseph D. Michienzi, Joshua A. Shreve, Abhijit Tarafder
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Patent number: 10996204Abstract: Methods for transferring a carbon dioxide based separation procedure from a reference chromatographic system to a target chromatographic system involve alternative techniques for determining system pressure drops not attributable to the column. One technique involves leveraging experimental chromatography to develop a correction factor that is a function of at least one correction coefficient and at least one ratio of the differential analyte retention time to the retention time in the reference system. Another technique involves leveraging other experimental measurements of tubing pressure drops under various condition to develop a lookup table that can be used to identify likely tubing pressure drops in the target system. A third technique leverages knowledge of the separation procedure and the target system and the likely nature of the relevant flow to calculate tubing pressure drops in the target system.Type: GrantFiled: April 9, 2018Date of Patent: May 4, 2021Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Joseph D. Michienzi, Joshua A. Shreve, Jason F. Hill, Abhijit Tarafder, Michael O. Fogwill, Keith Fadgen
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System and method for minimization of force variation in a solenoid within a pressurized flow system
Patent number: 10877497Abstract: Exemplary embodiments are directed to systems and methods used to minimize force variation from a solenoid through an operating stroke. The systems and methods generate a near constant or substantially constant force solenoid assembly which can be used in a force driven device, such as, for example, a pressure regulator for accurately controlling pressure in a pressurized flow system. The systems and methods are based on an initial solenoid characterization and include an application of springs and placement of the solenoid within the system at a gap distance to minimize variation in force in the operating stroke of a commercially available solenoid.Type: GrantFiled: March 7, 2013Date of Patent: December 29, 2020Assignee: Waters Technologies CorporationInventor: Joshua A. Shreve -
Publication number: 20200361043Abstract: The present technology generally relates to devices, systems and methods for providing robust sealing between surfaces in a pressurized system, such as a chromatography system. In particular, the devices, systems and methods relate to compliant and resilient parts that can be reused and/or reinstalled while providing a pressure tight sealing surface even within a high pressure environment (e.g., 1000 psi or greater).Type: ApplicationFiled: May 13, 2020Publication date: November 19, 2020Applicant: Waters Technologies CorporationInventors: Emily J. Berg, Joshua A. Shreve
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Patent number: D1007707Type: GrantFiled: August 4, 2021Date of Patent: December 12, 2023Assignees: STRATEC SE, Instrument Laboratory CompanyInventors: Ralf Wolf, Christopher Almy, Jr., Joshua A Shreve, Candice Bell, Benjamin E Newton