Abstract: One-step methods for forming phosphate-based enzyme inhibitors are disclosed. Methods include reacting o-phosphorylethanolamine with an acyl chloride at acidic conditions. Acyl chlorides can be derivatized. The phosphate-based enzyme inhibitors can inhibit enzymes of the pentose phosphate pathway including D-ribose-5-phosphate aldose-ketose isomerase enzymes such as T. cruzi ribose 5-phosphate isomerase type B and D-ribulose-5-phosphate 3-epimerase enzymes. Methods can be used in forming pharmaceutical compositions for use in treatment of disease caused by kinetoplastid parasites including T. cruzi, T. brucei, and Leishmania spp.

Abstract: The present disclosure provides a method and a system for the production and storage of electric energy. The method performed by a central control unit includes providing the power supply to a customer location from an electrical power supply system. The method further includes determining whether power supply is available from a remote power system. The availability of the power supply is determined based on determining whether electric power is being exchanged with an interface electrically connecting a gateway AC battery of the electrical power supply system to the remote power system. The method further includes charging and discharging of the AC batteries using power supply that is being exchanged between the gateway AC battery and the remote power system for providing power supply from the gateway AC battery to the customer location, and from photovoltaic panels equipped with AC/DC converters.

Abstract: The present disclosure provides methods and systems for automatically controlling power supply from an electrical power supply system to a user location based on payment status. The method performed by a central control unit includes determining a payment status of the electrical power supply system at the user location. The payment status is determined based at least on a time credit associated with the electrical power supply system. The method further includes facilitating control of the power supply from the electrical power supply system to the user location based on determining the time credit. The power supply to the user location from the electrical power supply system is uninterrupted, if the time credit is greater than a predefined threshold value. The power supply to the user location from the electrical power supply system is disconnected, if the time credit is less than the predefined threshold value.

Abstract: One-step methods for forming phosphate-based enzyme inhibitors are disclosed. Methods include reacting o-phosphorylethanolamine with an acyl chloride at acidic conditions. Acyl chlorides can be derivatized. The phosphate-based enzyme inhibitors can inhibit enzymes of the pentose phosphate pathway including D-ribose-5-phosphate aldose-ketose isomerase enzymes such as T. cruzi ribose 5-phosphate isomerase type B and D-ribulose-5-phosphate 3-epimerase enzymes. Methods can be used in forming pharmaceutical compositions for use in treatment of disease caused by kinetoplastid parasites including T. cruzi, T. brucei, and Leishmania spp.

Abstract: The present disclosure provides methods and systems for automatically controlling power supply from an electrical power supply system to a user location based on payment status. The method performed by a central control unit includes determining a payment status of the electrical power supply system at the user location. The payment status is determined based at least on a time credit associated with the electrical power supply system. The method further includes facilitating control of the power supply from the electrical power supply system to the user location based on determining the time credit. The power supply to the user location from the electrical power supply system is uninterrupted, if the time credit is greater than a predefined threshold value. The power supply to the user location from the electrical power supply system is disconnected, if the time credit is less than the predefined threshold value.

Abstract: The present disclosure provides a method and a system for the production and storage of electric energy. The method performed by a central control unit includes providing the power supply to a customer location from an electrical power supply system. The method further includes determining whether power supply is available from a remote power system. The availability of the power supply is determined based on determining whether electric power is being exchanged with an interface electrically connecting a gateway AC battery of the electrical power supply system to the remote power system. The method further includes charging and discharging of the AC batteries using power supply that is being exchanged between the gateway AC battery and the remote power system for providing power supply from the gateway AC battery to the customer location, and from photovoltaic panels equipped with AC/DC converters.

Abstract: Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

Abstract: Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.