Patents by Inventor Joyce Lichi YANG

Joyce Lichi YANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genome Engineering
    Publication number: 20220235382
    Abstract: Methods are provided for altering target DNA in a cell genetically modified to express a Cas 9 enzyme that forms a co-localization complex with a guide RNA complementary to the target DNA and that cleaves the target DNA in a site specific manner Methods include introducing into the cell a first foreign nucleic acid encoding a donor nucleic acid sequence, introducing into the cell from media surrounding the cell the guide RNA complementary to the target DNA and which guides the Cas 9 enzyme to the target DNA, wherein the RNA and the enzyme are members of a co-localization complex for the target DNA, wherein the donor nucleic acid sequence is expressed, wherein the guide RNA and the Cas 9 enzyme co-localize to the target DNA, the Cas 9 enzyme cleaves the target DNA and the donor nucleic acid is inserted into the target DNA to produce altered DNA in the cell.
    Type: Application
    Filed: April 7, 2022
    Publication date: July 28, 2022
    Inventors: George M. Church, Luhan Yang, Marc Guell, Joyce Lichi Yang
  • Genome engineering
    Patent number: 11306328
    Abstract: Methods are provided for altering target DNA in a cell genetically modified to express a Cas 9 enzyme that forms a co-localization complex with a guide RNA complementary to the target DNA and that cleaves the target DNA in a site specific manner. Methods include introducing into the cell a first foreign nucleic acid encoding a donor nucleic acid sequence, introducing into the cell from media surrounding the cell the guide RNA complementary to the target DNA and which guides the Cas 9 enzyme to the target DNA, wherein the RNA and the enzyme are members of a co-localization complex for the target DNA, wherein the donor nucleic acid sequence is expressed, wherein the guide RNA and the Cas 9 enzyme co-localize to the target DNA, the Cas 9 enzyme cleaves the target DNA and the donor nucleic acid is inserted into the target DNA to produce altered DNA in the cell.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: April 19, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Luhan Yang, Marc Guell, Joyce Lichi Yang
  • Genome engineering
    Patent number: 10563225
    Abstract: Methods are provided for the use of Cas9 in genome engineering of stem cells. Methods include introducing into the stem cell a first foreign nucleic acid encoding a guide RNA complementary to a target DNA and which guides a Cas9 enzyme to the target DNA, wherein the RNA and the enzyme are members of a co-localization complex for the target DNA, introducing into the stem cell a second foreign nucleic acid encoding a donor nucleic acid sequence, wherein the guide RNA and the donor nucleic acid sequences are expressed, wherein the guide RNA and the Cas 9 enzyme co-localize to the target DNA, the Cas 9 enzyme cleaves the target DNA and the donor nucleic acid is inserted into the target DNA to produce altered DNA in the stem cell.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: February 18, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Luhan Yang, Marc Guell, Joyce Lichi Yang
  • Genome engineering
    Patent number: 9914939
    Abstract: Methods of genome engineering in cells using a TALEN lacking repeat sequences or Cas9 is provided.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: March 13, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Luhan Yang, Marc Guell, Joyce Lichi Yang
  • Genome Engineering
    Publication number: 20160369301
    Abstract: Methods of genome engineering in cells using a TALEN lacking repeat sequences or Cas9 is provided.
    Type: Application
    Filed: July 25, 2014
    Publication date: December 22, 2016
    Inventors: George M. Church, Luhan Yang, Marc Guell, Joyce Lichi Yang
  • Genome Engineering
    Publication number: 20150031133
    Abstract: Methods of genome engineering in cells using a TALEN lacking repeat sequences or Cas9 is provided.
    Type: Application
    Filed: June 30, 2014
    Publication date: January 29, 2015
    Inventors: George M. CHURCH, Luhan YANG, Marc Guell CARGOL, Joyce Lichi YANG
  • Genome Engineering
    Publication number: 20150031132
    Abstract: Methods of genome engineering in cells using a TALEN lacking repeat sequences or Cas9 is provided.
    Type: Application
    Filed: June 30, 2014
    Publication date: January 29, 2015
    Inventors: George M. CHURCH, Luhan YANG, Marc Guell CARGOL, Joyce Lichi YANG