Patents by Inventor Joyce Running

Joyce Running has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid probes immobilized on polystyrene surfaces
    Patent number: 5747244
    Abstract: Nucleic acid probes are immobilized on polystyrene surfaces such as the wells of microtiter plates for use in solution phase nucleic acid sandwich hybridization assays, particularly those using large branched DNA amplification multimers, by: (a) cleansing the surface by washing it sequentially with a strong acid, a strong base, and water, (b) passively adsorbing a polypeptide having primary amino groups onto the cleansed surface, and (c) covalently bonding the probe to the adsorbed polypeptide via a base-stable bifunctional crosslinking agent, and (d) subjecting the surface to conditions that simulate the hybridization conditions used in the assay.
    Type: Grant
    Filed: December 23, 1991
    Date of Patent: May 5, 1998
    Assignee: Chiron Corporation
    Inventors: Patrick Sheridan, Chu-An Chang, Joyce Running, Michael S. Urdea
  • HBV capture and amplifiers probes for use in solution phase sandwich hybridization assays
    Patent number: 5736316
    Abstract: Novel DNA probe sequences for detection of HBV in a sample in a solution phase sandwich hybridization assay are described. Amplified nucleic acid hybridization assays using the probes are exemplified.
    Type: Grant
    Filed: January 24, 1994
    Date of Patent: April 7, 1998
    Assignee: Chiron Corporation
    Inventors: Bruce D. Irvine, Janice A. Kolberg, Joyce A. Running, Michael S. Urdea
  • Process for immobilizing nucleic acid probes on polystyrene surfaces
    Patent number: 5712383
    Abstract: Nucleic acid probes are immobilized on polystyrene surfaces such as the wells of microtiter plates for use in solution phase nucleic acid sandwich hybridization assays, particularly those using large branched DNA amplification multimers, by: (a) cleansing the surface by washing it sequentially with a strong acid, a strong base, and water, (b) passively adsorbing a polypeptide having primary amino groups onto the cleansed surface, and (c) covalently bonding the probe to the adsorbed polypeptide via a base-stable bifunctional crosslinking agent, and (d) subjecting the surface to conditions that simulate the hybridization conditions used in the assay.
    Type: Grant
    Filed: May 10, 1995
    Date of Patent: January 27, 1998
    Assignee: Chiron Corporation
    Inventors: Patrick Sheridan, Chu-An Chang, Joyce Running, Michael S. Urdea
  • Nucleic acid hybridization assay for hepatitis B virus DNA
    Patent number: 5614362
    Abstract: Linear or branched oligonucleotide multimers useful as amplifiers in biochemical assays which comprise (1) at least one first single-stranded oligonucleotide unit that is complementary to a single-stranded oligonucleotide sequence of interest, and (2) a multiplicity of second single-stranded oligonucleotide units that are complementary to a single-stranded labeled oligonucleotide. Amplified sandwich nucleic acid hybridizations and immunoassays using the multimers are exemplified.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: March 25, 1997
    Assignee: Chiron Corporation
    Inventors: Michael S. Urdea, Brian Warner, Joyce A. Running, Janice A. Kolberg, Jennifer M. Clyne, Ray Sanchez-Pescador, Thomas Horn
  • Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
    Patent number: 5359100
    Abstract: Linear or branched oligonucleotide multimers useful as amplifiers in biochemical assays which comprise (1) at least one first single-stranded oligonucleotide unit that is complementary to a single-stranded oligonucleotide sequence of interest, and (2) a multiplicity of second single-stranded oligonucleotide units that are complementary to a single-stranded labeled oligonucleotide. Amplified sandwich nucleic acid hybridizations and immunoassays using the multimers are exemplified.
    Type: Grant
    Filed: August 13, 1993
    Date of Patent: October 25, 1994
    Assignee: Chiron Corporation
    Inventors: Michael S. Urdea, Brian Warner, Joyce A. Running, Janice A. Kolberg, Jennifer M. Clyne, Ray Sanchez-Pescador, Thomas Horn